Gene Information

Name : guaA (NT05HA_0517)
Accession : YP_003007017.1
Strain : Aggregatibacter aphrophilus NJ8700
Genome accession: NC_012913
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 511819 - 513378 bp
Length : 1560 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCAACATTCACAACCATAAAATCCTCATCCTCGACTTTGGTTCCCAATACACCCAACTTATCGCCCGCCGTGTACG
TGAAATCGGTGTATATTGCGAGCTTTGGGCGTGGGATGTCACCGAACAACAAATCCGTGATTTCAACCCAACGGGGATTA
TCCTTTCCGGCGGTCCGGAAAGCACCACGGAAGAAAATAGCCCGCGTGCCCCTGAATATGTCTTTAGTGCCGGTGTTCCT
GTGCTGGGCATTTGCTACGGTATGCAAACCATGGCGATGCAGCTTGGCGGCTTAACAGAAACCTCCGATCATCGTGAGTT
TGGTTATGCTTCCGTTTTAATGGAAAATCCGACCGCACTTTTCGCCCATTTAAATGATGGCGACAGCAAATTGGACGTGT
GGATGAGCCACGGCGATAAAGTCACCCGCTTGCCACAAAATTTCCAAATCACCGGCATCACGCCGACCTGCCCGATTGCG
GCAATGTCTGATGAAAGCCGTCATTTCTACGGCGTGCAATTCCACCCGGAAGTCACACACACTAAAAAGGGCTTGGAATT
ATTAACTAATTTCGTGGTGAACATTTGTGGTTGCGAGACTAAATGGACCGCCGAAAACATTATCGAAGACGCCGTTGCCC
GCATTAAAGAACAAGTGGGCGATGACGAAGTCATTTTAGGTTTATCCGGCGGTGTTGACTCTTCTGTAGTAGCACTACTT
TTACACCGCGCTATCGGTAAAAACTTACACTGCGTATTCATAGATAACGGTTTACTCCGCTTACATGAAGGCGATCAAGT
GATGGAAATGTTTGGCGACAAATTCGGTTTAAACATCACCCGTGTGGATGCTGAAAGCCGTTTCTTAGGTGAACTTGCAG
GCGTATCCGATCCTGAAGCAAAACGTAAAATTATCGGTAAAGTATTCGTGGATGTATTCGATGATGAATCGAAAAAACTG
ACAAAAGTGAAATGGTTGGCACAGGGCACCATTTACCCTGACGTAATCGAATCGGCCGCCAGCAAAACAGGCAAAGCCCA
TGTCATTAAATCCCACCACAACGTAGGCGGCTTGCCTGATTATATGAAACTTGGCTTAGTCGAACCGTTGCGTGAATTGT
TCAAAGATGAAGTGCGTAAAATTGGCTTAGCGTTAGGCTTACCGGCAGAGATAATCAATCGCCACCCATTCCCGGGCCCG
GGTTTAGGCGTACGTGTACTCGGTGAAGTGAAAAAAGAATACTGCGATTTATTACGCCGTGCCGATGCCATCTTTATCGA
AGAATTACGCAACAGCGGTTGGTATGCCAAAACCAGCCAAGCCTTCAGCGTGTTCCTACCGGTGAAATCTGTAGGCGTGA
TGGGCGACGGACGTAAATATGACTGGGTGATTTCCTTACGTGCCGTAGAAACGATTGATTTTATGACCGCACATTGGGCA
CATTTGCCTTATGATCTGCTCGGAAAAATCTCCAACCGCATCATCAATGAAGTGAACGGCATTTCCCGCGTAGTCTATGA
CATTAGCGGTAAACCGCCGGCAACTATTGAGTGGGAATGA

Protein sequence :
MTNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIRDFNPTGIILSGGPESTTEENSPRAPEYVFSAGVP
VLGICYGMQTMAMQLGGLTETSDHREFGYASVLMENPTALFAHLNDGDSKLDVWMSHGDKVTRLPQNFQITGITPTCPIA
AMSDESRHFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSVVALL
LHRAIGKNLHCVFIDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDESKKL
TKVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEIINRHPFPGP
GLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYAKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMTAHWA
HLPYDLLGKISNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-130 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-131 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-131 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-110 48