Gene Information

Name : lysS (SDEG_0610)
Accession : YP_002996326.1
Strain : Streptococcus dysgalactiae GGS_124
Genome accession: NC_012891
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 579029 - 580534 bp
Length : 1506 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
TTGGAGGAAAATATGTCTAATCAACACATCGAAGAATTAAATGACCAACAGATTGTCCGTCGTGAAAAGATGATGGCTCT
GGCTGAACAAGGAATTGATCCTTTCGGTAAACGCTTTGACCGCACAGCCAATTCTGCTGAATTAAAAGAAAAGTATGCTG
ATAAAACAAAAGAAGAATTACATGAGTTAAACGAAACAGCTATTGTTGCTGGCCGCTTGATGACAAAACGTGGCAAAGGT
AAGGTTGGTTTTGCTCATCTTCAAGACCGGGAAGGCCAAATCCAACTTTATGTTCGCAAGGACTCTGTTGGCGAAGACAA
CTATGAAATCTTCAAAAAAGCCGATTTAGGCGACTTTATCGGCGTTGAAGGCGAAGTCATGCGTACAGACATGGGCGAGT
TGTCAATCAAGGCAACCAAGTTGACTCACCTTTCTAAATCACTTCGTCCTCTTCCTGAAAAATTCCACGGATTAACTGAT
ATTGAAACCATTTACCGTAAGCGTCACCTTGATTTAATTTCAAATCGTGAAAGCTTTGACCGCTTCGTGACCCGTTCCAA
AATGATTTCAGAAATCCGTCGTTATTTAGACGGACTTGATTTCCTAGAAGTAGAAACGCCTGTGCTTCATAACGAAGCTG
GTGGTGCTGCTGCTCGTCCTTTCGTTACTCACCATAATGCTCAAAACATTGACATGGTACTTCGTATCGCAACAGAACTT
CATTTGAAACGTTTGATTGTTGGTGGTATGGAACGTGTTTACGAAATTGGTCGTATCTTCCGTAATGAGGGAATGGATGC
TACTCATAATCCTGAGTTCACTTCTATTGAGGTTTACCAAGCCTATGCAGACTATCTTGATATCATGAACCTGACAGAAG
GCATTATCCAACATGCTGCTAAAGCTGTTAAAGGTGATGGCCCTATTGATTATCAAGGAACCGAAATCCGTATCAATGAA
CCTTTCAAACGTGTTCACATGGTAGATGCTATCAAGGAAGTGACAGGTGTTGATTTCTGGCCTGAAATGACTGTCGAAGA
AGCTATTGCACTTGCCAAAGAAAAACAGGTCCCACTCGAAAAACACTTCACAAGTGTCGGACATATCATCAATGCTTTCT
TCGAGGAATTTGTTGAAGAAACCTTGGTCCAACCAACCTTTGTCTTTGGTCATCCTGTTGAAGTATCGCCTTTGGCTAAG
AAGAATCCAGAAGATACCCGCTTCACCGACCGCTTCGAACTTTTCATCATGACCAAAGAATACGCCAATGCTTTCACAGA
GTTAAATGATCCCATTGACCAATTATCTCGTTTTGAAGCACAAGCACAAGCCAAAGAACTTGGTGATGACGAAGCAACTG
GCATTGACTACGACTTCGTTGAAGCTCTTGAATATGGTATGCCGCCAACCGGTGGACTCGGAATTGGTATTGACCGTCTC
TGCATGTTATTAACAAACACAACAACTATCCGAGATGTACTACTTTTCCCAACCATGAAACCTTAA

Protein sequence :
MEENMSNQHIEELNDQQIVRREKMMALAEQGIDPFGKRFDRTANSAELKEKYADKTKEELHELNETAIVAGRLMTKRGKG
KVGFAHLQDREGQIQLYVRKDSVGEDNYEIFKKADLGDFIGVEGEVMRTDMGELSIKATKLTHLSKSLRPLPEKFHGLTD
IETIYRKRHLDLISNRESFDRFVTRSKMISEIRRYLDGLDFLEVETPVLHNEAGGAAARPFVTHHNAQNIDMVLRIATEL
HLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADYLDIMNLTEGIIQHAAKAVKGDGPIDYQGTEIRINE
PFKRVHMVDAIKEVTGVDFWPEMTVEEAIALAKEKQVPLEKHFTSVGHIINAFFEEFVEETLVQPTFVFGHPVEVSPLAK
KNPEDTRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQAQAKELGDDEATGIDYDFVEALEYGMPPTGGLGIGIDRL
CMLLTNTTTIRDVLLFPTMKP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 9e-106 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_002996326.1 lysyl-tRNA synthetase VFG1668 Protein 5e-106 47