Gene Information

Name : TSIB_0471 (TSIB_0471)
Accession : YP_002993886.1
Strain : Thermococcus sibiricus MM 739
Genome accession: NC_012883
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 449784 - 451241 bp
Length : 1458 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
TTGAAAGAAAGGAGCAAAATGGTGAGAGAAATGGAGCTTCCCGATCACAAAACAAAAATAATTGCCACAATCGGCCCGGC
TTCAAGGCATGCGGGAACTATAGAAAAGATGATAAAAGCTGGAATGAGCGTTGCAAGGATAAACTTTTCTCACGGAACCC
TTGAGGAGCACACAAAGACCATTGAGCTGATAAGAAAAACCGCCGAGAAATTGGAAAAGATAGTTGCAATTCTGGGCGAT
CTGCCAGGGGTAAAAATGAGAGTTGGAAAGATAAAAGGAGACTCCATAACCTTAAAAAAGGGAGATAAAGTTGTACTCAC
AACAAGGGACGTTGAAGGAGATGAAACAACTATTCCCGTCGAGTTTAAAGATTTTCCAAAGCTGGTGTCAAAAGGAGATG
TAATATACTTAAGTGATGGTTACATAATGTTAAGGGTCGAGGAAGTTAGGGAGAACGAGGTCGAATGTGTTGTGGTGAAC
GGAGGTACATTGTTCTCTCATAAAGGAATAAACATCCCAAAGGCTAACCTTCCAATCGAAGCAATAACTCCAAGGGACTT
TGAGATAATCGAATTCGCAATTGAACAGGGAATAGATGCTATAGGCCTCTCTTTTGTAGGCTCTGTCTACGATGTTCTCA
AGGTAAAGAGCTTCCTGGAAAAGAAAAAGGGCAATAATTTTATAATAGCAAAAATAGAACGGCCGGATGCAGTGAGGAAC
TTTGATGAAATTCTAAATGCTGCTGATGGGATAATGGTAGCTAGAGGAGACCTAGGAGTAGAAATGCCAATCGAAAAACT
CCCCATAATGCAGAAACAACTTATAAAAAAGGCCAACTTAGCTGCAAAGCCTGTAATAACTGCCACCCAGATGCTTGTTT
CAATGACCACAGAGAGAATACCAAAGAGAGCAGAAGTCACAGACGTTGCAAATGCGATACTTGATGGCACAGATGCCGTA
ATGCTCTCTGAAGAAACTGCCATAGGGAAATACCCTGTGGAATCAGTAGAGATGATGGCTAAAATAGCCAAGACAACAGA
GGAATATAGAGAATCCCTAGGACACTCCAGATTACGCGCTTGGATTGACTTACTGCCAAAAAGGAGCACGATAAAAGAAG
CAATAACACAGAGCGTTATAGATGCCCTCTGTGCCATAGACATAAAATACATCCTAACCCCAACAAGAACAGGATTAACT
CCAAGGCTCATCTCACGTTTTAAACCAAAACAGTGGATTTTAGCCTTTTCAAATAACGAAAGAGTCTGTAACAGCTTAGC
CTTTTCCTATGGAGTTTACCCATTCTGCATGGAAGAAGAGTTCAATGAAAAGGACATGATAATGTTAGTAAAGGGGTTGG
GAATAGTCAAAGAAGATGATACAGTTCTCTTAACAGAAGGAAAACCAATAGGAAAGACTATAGGGACAAATACGATACGT
ATTTTCCAAATTCCTTAA

Protein sequence :
MKERSKMVREMELPDHKTKIIATIGPASRHAGTIEKMIKAGMSVARINFSHGTLEEHTKTIELIRKTAEKLEKIVAILGD
LPGVKMRVGKIKGDSITLKKGDKVVLTTRDVEGDETTIPVEFKDFPKLVSKGDVIYLSDGYIMLRVEEVRENEVECVVVN
GGTLFSHKGINIPKANLPIEAITPRDFEIIEFAIEQGIDAIGLSFVGSVYDVLKVKSFLEKKKGNNFIIAKIERPDAVRN
FDEILNAADGIMVARGDLGVEMPIEKLPIMQKQLIKKANLAAKPVITATQMLVSMTTERIPKRAEVTDVANAILDGTDAV
MLSEETAIGKYPVESVEMMAKIAKTTEEYRESLGHSRLRAWIDLLPKRSTIKEAITQSVIDALCAIDIKYILTPTRTGLT
PRLISRFKPKQWILAFSNNERVCNSLAFSYGVYPFCMEEEFNEKDMIMLVKGLGIVKEDDTVLLTEGKPIGKTIGTNTIR
IFQIP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 8e-52 44
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 7e-53 41
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-53 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-53 41
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-53 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TSIB_0471 YP_002993886.1 pyruvate kinase VFG0479 Protein 1e-53 41