Gene Information

Name : TSIB_1834 (TSIB_1834)
Accession : YP_002995234.1
Strain : Thermococcus sibiricus MM 739
Genome accession: NC_012883
Putative virulence/resistance : Unknown
Product : carbamate kinase-like carbamoyl phosphate synthetase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0549
EC number : 2.7.2.2
Position : 1651441 - 1652388 bp
Length : 948 bp
Strand : -
Note : this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable react

DNA sequence :
ATGAGAAAGAGAGTTGTCATAGCTTTAGGTGGGAATGCTATTCTTCAAAGGGGTCAGAAAGGTACTTATGAAGAGCAAAT
GGAGAATGTGAGAAAGACTGCAAGGCAGATTGTTGATATTATTCTTGATAATGAGTATGAAGTGGTTATCACTCATGGTA
ATGGTCCTCAAGTTGGAGCTCTTCTTCTCCAACAGGATGCTGGAGAGCACGTGCATGGAATTCCTGCTCAACCTATGGAT
GTTTGTGGTGCAATGAGTCAGGGTCAAATAGGTTACATGATTCAGCAGGCAATAATGAATGAATTGAGGAGGAGGGGTGT
TGAACGGCCAGTGGCGACTATAGTCACCCAAACTATTGTGGACAAGAATGATCCCGCTTTTCAGCACCCATCAAAACCAG
TTGGGCCCTTCTATAGTGAAGAGACTGCTAAAAAACTCGCTAAGGAGAAAGGTTGGGTGGTTATAGAGGACGCTGGAAGG
GGTTGGAGGAGGGTAGTGCCAAGTCCAGACCCAAAGGGACATGTAGAGGCTCCCATAATCCAAGATCTTGTTGAAAAAGA
ATTTATAGTGATATCTTCAGGTGGTGGAGGAATTCCTGTTGTAGAGGAGAATGGTGAGCTTAAGGGCGTTGAAGCAGTTA
TTGACAAAGATCTGGCTGGAGAAAGGCTTGCTGAGGAAGTTAACGCTGATATTTTCATGATTCTTACGGATGTTAATGGA
GCTGCAATTAACTATGGTAGACCTAACGAAAAGTGGCTTGAAAAGGTTACTTTGGGAGAAATAAAGAGGTATTATGAGGA
AGGCCACTTCAAAAAGGGTAGCATGGGGCCAAAAGTACTTGCAGCAATAAGGTTTATTGAGTGGGGTGGGGAGAGGGCAA
TAATAGCGGCACTGGATAAGGCTGTTGAGGCATTGGAAGGAAAAACAGGCACCCAAATAACAAGATGA

Protein sequence :
MRKRVVIALGGNAILQRGQKGTYEEQMENVRKTARQIVDIILDNEYEVVITHGNGPQVGALLLQQDAGEHVHGIPAQPMD
VCGAMSQGQIGYMIQQAIMNELRRRGVERPVATIVTQTIVDKNDPAFQHPSKPVGPFYSEETAKKLAKEKGWVVIEDAGR
GWRRVVPSPDPKGHVEAPIIQDLVEKEFIVISSGGGGIPVVEENGELKGVEAVIDKDLAGERLAEEVNADIFMILTDVNG
AAINYGRPNEKWLEKVTLGEIKRYYEEGHFKKGSMGPKVLAAIRFIEWGGERAIIAALDKAVEALEGKTGTQITR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0102 NP_763657.1 carbamate kinase Not tested SCCpbp4 Protein 3e-52 47
APECO1_2636 YP_859422.2 carbamate kinase Not tested Not named Protein 2e-50 46
arcC1 YP_186045.1 carbamate kinase Not tested vSa¥ã Protein 6e-55 45
MW1051 NP_645868.1 carbamate kinase Not tested vSa¥ã Protein 6e-55 45
SAV1170 NP_371694.1 carbamate kinase Not tested vSa¥ã Protein 6e-55 45
SA1013 NP_374286.1 carbamate kinase Not tested vSa¥ã Protein 6e-55 45
arcC YP_493761.1 carbamate kinase Not tested vSa¥ã Protein 6e-55 45
SAKOR_01091 YP_008491279.1 Carbamate kinase Not tested vSa¥ã Protein 1e-55 45