Gene Information

Name : guaA (Rpic12D_1372)
Accession : YP_002981333.1
Strain :
Genome accession: NC_012856
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1453304 - 1454923 bp
Length : 1620 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGACAAAGTCCTCATCCTTGATTTCGGCTCGCAGGTCACGCAACTGATTGCGCGGCGCGTGCGGGAAGCACACGT
CTATTGCGAGATCCACCCGAACGACGTGTCCGACGCTTTCGTGCGCGAGTTCGCACCGAAGGCGATCATCCTGTCCGGCA
GCCACGCCAGCACCTACGAAGATCATCAACTGCGTGCTCCGCAGGCCGTGTGGGACTTGGGCGTGCCCGTGCTTGGCATC
TGCTACGGCATGCAGACCATGGCCGTGCAGCTGGGCGGCAAGGTCGAGTGGAGCGATCACCGCGAATTCGGTTACGCCGA
AGTGCGCGCGCATGGCCACACCCGCCTGCTCAAGGACATCCAGGACTTCGCCACGCCGGAAGGCCACGGCATGCTCAAGG
TGTGGATGAGCCACGGCGACAAGGTCGCCGAGCTGCCCCCGGGCTTCAAGCTGCTGGCCTCAACGCCGAGCTGCCCCATC
GCCGGCATGGCCGACGAGGCGCGTGGCTACTACGCCGTGCAGTTCCACCCGGAAGTCACGCACACCGTGCAGGGCCGCGC
AATGCTCGAGCGTTTCGTGCTGGAGATCGCCGGTGCCAAGCCAGACTGGATCATGCGCGACCACATCGAGGAAGCCGTCA
AGCGCATCCGCGAGCAGGTCGGCGATGAAGAGGTGATCCTCGGCCTGTCGGGCGGCGTCGATTCGTCGGTGGCGGCGGCG
CTCATTCACCGCGCGATCGGTGACCAACTGACCTGCGTGTTCGTCGACCACGGCCTGCTGCGCCTGGACGAAGGCAAGAT
GGTGATGGACATGTTCGCCGGCCGCCTGCACGCCAAGGTCGTGCACGTGGACGCGTCTGAGCAGTTCCTCGGCCACCTGG
CCGGTGTGACGGACCCGGAAGCCAAGCGCAAGATCATCGGCCGCGAGTTCGTTGAGGTGTTCCAGGCCGAAGCCAAGAAA
CTCAGCAACGCCAAGTGGCTGGCGCAGGGCACGATCTACCCGGACGTGGTGGAATCGGGCGGCACCAAGACCAAGAAGGC
AACGACGATCAAGAGCCACCACAACGTGGGCGGCCTGCCGGAAACACTCGGCCTGAAGTTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGATGAAGTGCGCGAGCTGGGCGTGGCGCTGGGCCTGCCGCACGAAATGGTCTATCGCCATCCGTTCCCGGGG
CCGGGCCTGGGCGTGCGTATTCTGGGCGAGGTCAAGCGCGAATACGCAGACCTGCTGCGCCGTGCCGACGCCATCTTCAT
CGAAGAGCTGCGTGGTACCAAGGCCACGGCGCAGGACGCTGCCGCTGGCCTCTGCGGCGAAGGCGATGTGGGCAAGAGCT
GGTACGACCTGACCAGCCAGGCGTTTGCGGTGTTCCTGCCGATCAAGTCCGTCGGCGTGATGGGCGATGGCCGCACGTAC
GACTACGTGACGGCGCTGCGCGCAGTGCAGACCACCGATTTCATGACCGCACATTGGGCGCATCTGCCGTACACGCTGCT
GGGCCGCGTGTCGAACCGCATCATCAACGAGGTGCGTGGTTTGAGCCGCGTCGTGTATGACGTGTCGGGCAAGCCGCCCG
CGACGATCGAGTGGGAGTGA

Protein sequence :
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDIQDFATPEGHGMLKVWMSHGDKVAELPPGFKLLASTPSCPI
AGMADEARGYYAVQFHPEVTHTVQGRAMLERFVLEIAGAKPDWIMRDHIEEAVKRIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYTLLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-117 49
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-117 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-117 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-107 48