Gene Information

Name : Rpic12D_5352 (Rpic12D_5352)
Accession : YP_002973820.1
Strain :
Genome accession: NC_012849
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 240388 - 242787 bp
Length : 2400 bp
Strand : +
Note : TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: rme:Rm

DNA sequence :
GTGAGCGAATGCGGCCCGAAGGGATGCGATTGCGCTGCTGTCAACGTGGCGCCTCCGGCCCCCGATGCAACTGGCGTCGA
TTTGAAGCGCTCGCGCTACCGGATCGACAACATGGATTGCCCAACCGAGGAAGCGCTCATTCGCAACAAGCTGGCGACGT
TGCCTGGGGTGGTGAAGCTTGAGTTCAATCTGGTACAGCGTTCGCTGACCGTCAATCACCGGCTGCCGTCCCCGGCCTCA
ATCGAACAGGCGTTGTCGGCCATTGGCATGCAAGCCGTGCGCGCGGAAGAGACGCGTTCCGCGCAAAGCACGGTCCTGAC
CATCCGGCAGATGGACTGTCCCACTGAGGAAGCACTGATTCGGGGCAAGCTGGCGGGCGTGCCGGGTGTGGCCGGTCTTG
ATTTCAACCTCGTTCAGCGCACGCTGGCGGTCCGTCACGCTGCGCACACGTTGCCCCAAGTATTGGCCGCCATCCAATCG
CTTGGCTTCGATGCCGAGGTCCGCGACACCTCCGCTGCCGCACCCGCTTCTGTGCCGGATGCCGCGCCCACCAAATGGTG
GCCGCTTGCCATTTCCGGGGCGAACGCCGTACTGGCGGAGGTCGTCTATTGGCTCAACGGTGGCAATCACTGGGTGGTGG
TGGTCCTGGCATTAGCCGCGATCCTGACCGGCGGGCTCACCACCTACAAGAAAGGCTGGATCGCGCTCAAGAACCGCAAC
CTGAACATGAGTGCCCTCATGTCGATTGCGGTGACGGGCGCGATGGTGATCGGCCACTGGCCGGAAGCAGCGATGGTGAT
GGTCTTGTTCGCGCTGGCCGAAGTCGTCGAAGCCCGGTCGCTGGATCGTGCGCGTGACGCGATCCGTGGTTTGATGGATC
TCGCGCCCGAGACCGCCATGGTTCAGCGCAGCGATGGGAGCTGGGGCGACGTCGATGCCAAGACCGTTGCCGTCGGCAGC
CGGGTGCGGGTCAAGCCGGGCGAGCGCATCGCGCTCGATGGCGAGGTGCTGCAGGGGCGCTCCTCCGTGAACCAGGCACC
GATTACGGGCGAGAGCCTGCCGGTCGAGAAGGCGGAAGGCGACCCGGTGTTCGCCGGCACCATCAACGAGTCCGGATCGT
TCGAGTACCGCGTCACCGCGGCGGCAAGCGACTCTACGCTGGCACGCATCATCCACGCAGTGGAGGCTGCTCAAGGCAGT
CGCGCACCCACGCAGCGTTTCGTTGATCAGTTCGCCCGGCTGTACACCCCCATCGTCTTCGCCGTCGCGCTGGCGGTGGC
CATCTTGCCGCCGCTCCTGTTCGGTGCCGCCTGGCTGGATTGGATCTACAAGGCCCTCGTACTGCTGGTGATCGCGTGTC
CCTGCGCCCTCGTGATTTCGACGCCGGTGAGCATCGTGAGCGGCCTGGCCGCCGCCGCGCGACGCGGCATCCTGATCAAG
GGCGGGGTCTATCTCGAAGAGGGGCGCAAGCTGAAATGGTTGGCGCTCGACAAGACCGGCACCATCACACACGGCAAGCC
GGCGCTCACCGATGTCATGGCCTGGAACGGCACAGACCCCTCGGCCGCCGAGAGGCTTGCCGCCAGCCTGGCGATTCGCT
CCGACCACCCCGTCTCTCAGGCGGTGGCCCGCGCAGCGCAGGACAAAGGTCTCACCCCAGGCGAGGTCGCCGATTTCGCG
GCCATGCCTGGGCGCGGCGTCCGGGGCCATATCGACGGTGCGCTCTATCACTTGGGCAATCATCGCCTGGTTGAGGAACT
CGGGGTGTGCTCGCCGGCATTGGAAACCAACCTTGCCACCCTCGAAACCCAGGGCAAAACCGTCGTGATGCTGATCGGCC
CGGACGGCGTACGCGCGCTGTTCGGCGTGGCCGACACCATCAAGGACAGCAGTCGCCAGGCGATCAAGGACCTGCACGCG
CTGGGCATCAAAACCGTGATGCTCAGTGGTGACAACCCGCACACCGCGGAGGCGATCGCGCAGCAAGTGGGTATCGACAA
AGCTCGGGGCAACCTGCTACCGGAAGACAAGCAGCGCGAAATCGAGCAGCTATCGGCACAGGGAACCATCGGCATGGTCG
GCGATGGCATCAACGACGCGCCGGCGCTGGCACGGGCCGATATCGGTTTCGCGATGGGGGCCGCCGGGACGGACACGGCG
ATCGAAACGGCCGACGTCGCGCTGATGGACGACGATCTGCGCAAGCTCCCGGCCTTTGTACGGCTATCCCGGTCCACGGC
GGGAGTTCTGAAGCAGAACATTGCGCTGGCGCTCGGCATCAAGGTGGTGTTCCTGGTGCTGACCTTTACCGGCCAGGCCA
CCATGTGGATGGCGGTGTTTGCCGACATGGGGGCCAGCCTGCTGGTGGTCGGCAACGGGCTGAGGTTGCTGCGCAAATGA

Protein sequence :
MSECGPKGCDCAAVNVAPPAPDATGVDLKRSRYRIDNMDCPTEEALIRNKLATLPGVVKLEFNLVQRSLTVNHRLPSPAS
IEQALSAIGMQAVRAEETRSAQSTVLTIRQMDCPTEEALIRGKLAGVPGVAGLDFNLVQRTLAVRHAAHTLPQVLAAIQS
LGFDAEVRDTSAAAPASVPDAAPTKWWPLAISGANAVLAEVVYWLNGGNHWVVVVLALAAILTGGLTTYKKGWIALKNRN
LNMSALMSIAVTGAMVIGHWPEAAMVMVLFALAEVVEARSLDRARDAIRGLMDLAPETAMVQRSDGSWGDVDAKTVAVGS
RVRVKPGERIALDGEVLQGRSSVNQAPITGESLPVEKAEGDPVFAGTINESGSFEYRVTAAASDSTLARIIHAVEAAQGS
RAPTQRFVDQFARLYTPIVFAVALAVAILPPLLFGAAWLDWIYKALVLLVIACPCALVISTPVSIVSGLAAAARRGILIK
GGVYLEEGRKLKWLALDKTGTITHGKPALTDVMAWNGTDPSAAERLAASLAIRSDHPVSQAVARAAQDKGLTPGEVADFA
AMPGRGVRGHIDGALYHLGNHRLVEELGVCSPALETNLATLETQGKTVVMLIGPDGVRALFGVADTIKDSSRQAIKDLHA
LGIKTVMLSGDNPHTAEAIAQQVGIDKARGNLLPEDKQREIEQLSAQGTIGMVGDGINDAPALARADIGFAMGAAGTDTA
IETADVALMDDDLRKLPAFVRLSRSTAGVLKQNIALALGIKVVFLVLTFTGQATMWMAVFADMGASLLVVGNGLRLLRK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 0.0 70
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-121 49
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-121 49
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-119 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Rpic12D_5352 YP_002973820.1 heavy metal translocating P-type ATPase BAC0298 Protein 0.0 80
Rpic12D_5352 YP_002973820.1 heavy metal translocating P-type ATPase BAC0455 Protein 5e-93 42
Rpic12D_5352 YP_002973820.1 heavy metal translocating P-type ATPase BAC0461 Protein 2e-86 42