Gene Information

Name : thyA (Balat_0457)
Accession : YP_002969466.1
Strain : Bifidobacterium animalis DSM 10140
Genome accession: NC_012815
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 544656 - 545528 bp
Length : 873 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCCATTGATTCAGGAGCAACTGCAAGCTATTCGCACCCAGATTCCGCCGCGCCCCGACACCGACATCCCGATGCCGTA
TGAGGACCTGCTGCGCAAGATTCTCATGGAAGGCAATCTCAAGAACGACCGCACCGGCACAGGCACGATCTCGCTGTTCG
GCCAGCAGATGCGTTTCGATCTGGCGAAGGGGTTCCCGCTGCTCACCACGAAGCGCGTGTTCTTCAAGGGCATCGCCTAT
GAACTGCTGTGGTTCTTGAAGGGCTCGAGCAATGTGCACTGGCTGCAGGAGCACAATGTGCACATCTGGGACGAGTGGGC
CGACGAGAACGGTGATCTTGGTCCGGTGTACGGTGTGCAGTGGCGCAGTTGGCCTGCTCCCACCGCAGACGATCCCGACC
GCACAATCGACCAGATCTCCAATGTGCTTGAGCTCATCAAACACAACCCGGATTCGCGGCGCATGGTGGTCACCGCGTGG
AACCCGGCCGAGGTGGAGAACATGGCGTTGCCGCCGTGCCACGCGCTGTTCCAGTTCTATGTGGCCGATGGCAGACTCAG
CTGCCAGCTGTACCAGCGTTCGTGTGACATGTTCCTCGGCGTGCCGTTCAACATCGCCAGCTATTCGCTGCTCACGATGA
TGATGGCACAGCAGGCCGGCTTGGAACCCGGTGAATTCGTGTGGACCGGCGGCGACTGCCACATCTACGACAATCACGTG
GAGCAGGTGCTTGAGCAGCTCTCGCGCGAACCCTACCCATACCCGAGGATGGAGATTCGCAAGGCCGATTCTCTGTTCGA
CTACCAGTATTCCAATTTCCATATCGCGGACTATCGATACCACCCCACCATCAAGGCTCCGATCGCGGTGTGA

Protein sequence :
MPLIQEQLQAIRTQIPPRPDTDIPMPYEDLLRKILMEGNLKNDRTGTGTISLFGQQMRFDLAKGFPLLTTKRVFFKGIAY
ELLWFLKGSSNVHWLQEHNVHIWDEWADENGDLGPVYGVQWRSWPAPTADDPDRTIDQISNVLELIKHNPDSRRMVVTAW
NPAEVENMALPPCHALFQFYVADGRLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLEPGEFVWTGGDCHIYDNHV
EQVLEQLSREPYPYPRMEIRKADSLFDYQYSNFHIADYRYHPTIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-90 68