Gene Information

Name : zntA (MexAM1_META2p0203)
Accession : YP_002966452.1
Strain :
Genome accession: NC_012811
Putative virulence/resistance : Resistance
Product : zinc, cobalt and lead efflux system
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 181052 - 183247 bp
Length : 2196 bp
Strand : -
Note : Evidence 2b : Function of strongly homologous gene; Product type t : transporter

DNA sequence :
ATGAACCAAGCCGCCCCTACGGACCCGACATCATCTCCCACCACGGGCAATCAGGCCCTGCGCTACAGAGTCAAGGGCAT
GGACTGCCCAACCTGCGCCGGGAAGATCGAGAACGCCGTCTCCCGGCTGCCGGGTGTCGCGGACGTTCGCGTAAACTACG
GCAGCCAGGTTCTCGACCTGGCGCTCGACGAGGGCGTCACCCCGAGGACCGAGTTGGAGGGGCGCGTCGAACGCCTGGGC
TACGGCGTCGCGCCGCTGCCCACGGCCGCGGACCTGGCCAAGGCCCGGGCCGAGGGTGTCGCCCCGCCGGCCGGGACCAT
GGAGGATGCCGAACCGCCGCTCTGGCGGAGCCGCAAGGCGCTGCTGGGCATTCTCATCGGCACCCTGTTCGCCGCCGGGT
TCATCGTCGAGCGGATCGCGCCCGGCTTGGCGGGCGAGTACGCCTACTGGCCGGGGGCGCTCGTCGGGCTCGCCTATTAC
GGGCGCCGCGCGGTCGTGGCGGCCACGGCCGGCACGCCTTTCTCCATCGAGATGCTGATGTCGGTGGCGACGGCGGGGGC
GCTGGCCATCCATGCGGCCGAGGAGGCCGCCATCGTCGTCCTGCTCTTCACGGTCGGCGAGATGTTGGAGGTCGTGGCGG
CGGGGCGCGCACGCGCCGGCATCAAGGCGCTTGCGGCCCTGGTGCCTAAGACTGCCCGCCTCGTCGACGAAGCCGACGGC
ACGATCCGGGAGGTGCCCGCGGCGTCGCTCGCCATCGGGCAGGTCGTCGTGGTGAGGCCGGGCGACCGCGTGCCCGCCGA
CGGCGTGATCACGGATGGCTCGTCGAGCCTCGACGAGTCCCCCATCACCGGCGAGTCGGTCCCGAAGGCCAAGGAGGTTG
GTGACACGGTCTACGCCGGCAGCGTCAACGCCGACGGCGCACTCCAGGTCCGCGTCACCAAGACAGCGGCGGACAACACG
GTCGCCCGCATCCTCCACTTGGTCGAGGAGGCGCAGGCATCGAAGTCGCCCACGGCCCGCTTCATCGACCGGTTCAGCGC
GGTCTACACGCCCATCGCCTTCGCATTCGCGGCCGCCGTCGCGGTCCTGCCGCCGCTCCTCGGTGCCGACTGGGGCACTT
GGGTCTACCGGGGGCTCGCGCTCCTCCTCATCGCCTGCCCCTGCGCCCTCGTGCTCTCGACGCCGGCGGCCATCGCATCG
GGGTTGGCCGCCGGGGCGCGGCGCGGGCTGCTCGTGAAGGGCGGGGCGGCGCTGGAGGTCATCGGGCGGGTGCGCACGGT
GGCGTTCGACAAGACGGGAACCCTGACGGCTGGACGGCCGCGGGTCACCGACATCCTGGTCTTCGCGCCGGATGCGTCGG
AGCGCTCGCTTCTCGGATTGGCCGCCGCAGTCGAGAACGGGTCCAGCCATCCCATCGCCCGGGCCATCCTGGACCGGGCG
AACGAGGACGGGGTGCCGCTCCGGCCGACGCGCGATGCCCGCGCCACCCCCGGCAAGGCCGTGCAGGCCACGGTCATGGG
CCAGACGGTGCTTGTGGCCTCGCCGCGCCACGCCGCCGATAGCCTCCGGCTTGGCCCGGAGGCGGACCGTGCCGTCGCCG
GCCTGGAGACCAGTGGCAAGACGGTGGTCATCATCATCCGCGGCACCGAGGCACTGGGCGCCATCGCGGTCCGGGACGAG
CCCCGTGCCGACGCGGCCGCCGGCATCGCGGCCCTGCGGAAGCTGGGCGTGCGCAGCGTGATGCTGACCGGCGACAATCG
CCGCGCGGCCGAGGCGGTCGCGTCCGAACTCGGCCTCGACGTGAAGGCCGAGCTCCTGCCGCAAGACAAGCTCGCCGAGA
TCGCGGCCCTGAAGGAGGAGGGCCCGGTCGCGATGGTCGGCGACGGCATCAATGACGCGCCTGCCCTGGCCTCCGCCAGC
GTCGGCATCGCGATGGGCGGCGGCACGGACGCGGCCCTGGAAACGGCGGACGCCGCGGTGCTGAACGACCGCGTGGGAGA
CGTGGCCGCCCTCGTCGCCTTGTCCCGGGCGACGCTGGGAAACATCCGCCAGAACGTCGCCATCGCGCTCGGCCTGAAGG
CGGTGTTCCTGGTGACGACCATCGCCGGCATCACCGGCCTCTGGCCCGCCATCCTGGCCGATACCGGCGCGACCGTCCTG
GTGACGGCCAACGCGCTCCGTCTCCTGAGGGCATGA

Protein sequence :
MNQAAPTDPTSSPTTGNQALRYRVKGMDCPTCAGKIENAVSRLPGVADVRVNYGSQVLDLALDEGVTPRTELEGRVERLG
YGVAPLPTAADLAKARAEGVAPPAGTMEDAEPPLWRSRKALLGILIGTLFAAGFIVERIAPGLAGEYAYWPGALVGLAYY
GRRAVVAATAGTPFSIEMLMSVATAGALAIHAAEEAAIVVLLFTVGEMLEVVAAGRARAGIKALAALVPKTARLVDEADG
TIREVPAASLAIGQVVVVRPGDRVPADGVITDGSSSLDESPITGESVPKAKEVGDTVYAGSVNADGALQVRVTKTAADNT
VARILHLVEEAQASKSPTARFIDRFSAVYTPIAFAFAAAVAVLPPLLGADWGTWVYRGLALLLIACPCALVLSTPAAIAS
GLAAGARRGLLVKGGAALEVIGRVRTVAFDKTGTLTAGRPRVTDILVFAPDASERSLLGLAAAVENGSSHPIARAILDRA
NEDGVPLRPTRDARATPGKAVQATVMGQTVLVASPRHAADSLRLGPEADRAVAGLETSGKTVVIIIRGTEALGAIAVRDE
PRADAAAGIAALRKLGVRSVMLTGDNRRAAEAVASELGLDVKAELLPQDKLAEIAALKEEGPVAMVGDGINDAPALASAS
VGIAMGGGTDAALETADAAVLNDRVGDVAALVALSRATLGNIRQNVAIALGLKAVFLVTTIAGITGLWPAILADTGATVL
VTANALRLLRA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-96 41
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 7e-97 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
zntA YP_002966452.1 zinc, cobalt and lead efflux system BAC0461 Protein 9e-108 48
zntA YP_002966452.1 zinc, cobalt and lead efflux system BAC0092 Protein 7e-71 42
zntA YP_002966452.1 zinc, cobalt and lead efflux system BAC0124 Protein 1e-71 42