Gene Information

Name : ldhA (MexAM1_META1p4794)
Accession : YP_002965686.1
Strain : Methylobacterium extorquens AM1
Genome accession: NC_012808
Putative virulence/resistance : Resistance
Product : fermentative D-lactate dehydrogenase, NAD-dependent
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1052
EC number : 1.1.1.28
Position : 4901694 - 4902704 bp
Length : 1011 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9025293; Product type e : enzyme

DNA sequence :
ATGGACGTCACGATCTTCAGCACCAAGGCCTATGATCGGCGGTTCCTGGACGGGGCCAACGCGGCGGCGGGAGAGCCGCA
CCGGCTGCGCTATCTCGAAGCCCGGTTGACCCATGAGAGCGCGCCGCTGACGCAGGGAGCGCAGGCCGTGTGCGCCTTCG
TCAACGATGTGCTCGACCGGCCCGTTCTGGAGGTGCTGGCCGCCTCGGGCACGCGGATGGTGGCCCTTCGCAGCGCCGGC
TTCAACAATGTCGATCTTCCCGCCGCCGCGGAACTCGGCATCGCGGGCGGCCGCGTCCCGGCCTATTCGCCGGACGCGGT
CGCCGAGCATACGGTGGCCCTGATCCTCGCGCTCAATCGCAAGACCCACCGGGCCTATGCCCGCGTCCGCGAGGGGAATT
TCGCGCTCGAGGGGTTGCTGGGCTTCGATCTCAAGGGGCGCACGGTCGGCATCGTCGGAACCGGCAAGATCGGTCGCGCG
GTCGCGCGCATCCTCGCCGGCTTCGGCTGCCGCGTGCTGGCCTATGATCCCATGCCCTCGGCCGAACTCGCCGACTTCGG
CGCGGAGGCCGTGGGCCTCGACCGACTTCTGGCCGAGGCGGACATCGTCTCCCTGCACTGTCCGCTGACGCCCGACACGC
ATCACATGATCGACCGTGCCGCGCTGGCGCGGATGAAGCGTGGCGTGATGCTGATCAATACGGGGCGCGGGGCGCTCGTC
GATACCGCGGCGCTGATCGAGGGTTTGAAATCAGGGGTGATCGGCGATCTCGGCCTCGACGTCTACGAGGAGGAAGGCGG
CCTCTTCTTCGAGGATCTGTCGAACCAGATCATCCGGGACGACGTCTTCTCGCGCCTGCTGACCTTCCCGAATGTGATCG
TGACGGGGCATCAGGCCTTCTTCACCGCCGAGGCGCTGGCGGCGATTGCCGCGACCACCATCGAGAACCTGTCCTGCTTC
GAGACGCAGGGCGTTCCGCGGCATCCCGTATCGGTCGAGCGCCTCGCCTGA

Protein sequence :
MDVTIFSTKAYDRRFLDGANAAAGEPHRLRYLEARLTHESAPLTQGAQAVCAFVNDVLDRPVLEVLAASGTRMVALRSAG
FNNVDLPAAAELGIAGGRVPAYSPDAVAEHTVALILALNRKTHRAYARVREGNFALEGLLGFDLKGRTVGIVGTGKIGRA
VARILAGFGCRVLAYDPMPSAELADFGAEAVGLDRLLAEADIVSLHCPLTPDTHHMIDRAALARMKRGVMLINTGRGALV
DTAALIEGLKSGVIGDLGLDVYEEEGGLFFEDLSNQIIRDDVFSRLLTFPNVIVTGHQAFFTAEALAAIAATTIENLSCF
ETQGVPRHPVSVERLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF2295 NP_815952.1 D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 3e-39 43
vanHB YP_008394258.1 VanH protein, D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 7e-38 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ldhA YP_002965686.1 fermentative D-lactate dehydrogenase, NAD-dependent U35369.1.gene5.p01 Protein 5e-40 43
ldhA YP_002965686.1 fermentative D-lactate dehydrogenase, NAD-dependent NC_014475.1.orf2.gen Protein 2e-36 43
ldhA YP_002965686.1 fermentative D-lactate dehydrogenase, NAD-dependent NC_005054.2598279.p0 Protein 2e-36 43
ldhA YP_002965686.1 fermentative D-lactate dehydrogenase, NAD-dependent AF130997.1.orf3.gene Protein 2e-42 42
ldhA YP_002965686.1 fermentative D-lactate dehydrogenase, NAD-dependent AF310956.2.orf4.gene Protein 2e-38 42
ldhA YP_002965686.1 fermentative D-lactate dehydrogenase, NAD-dependent AF155139.2.orf4.gene Protein 5e-39 41