Gene Information

Name : MexAM1_META1p4325 (MexAM1_META1p4325)
Accession : YP_002965238.1
Strain : Methylobacterium extorquens AM1
Genome accession: NC_012808
Putative virulence/resistance : Resistance
Product : Gentamicin 3'-N-acetyltransferase
Function : -
COG functional category : R : General function prediction only
COG ID : COG0456
EC number : 2.3.1.60
Position : 4416366 - 4416914 bp
Length : 549 bp
Strand : -
Note : Evidence 2b : Function of strongly homologous gene; PubMedId : 2549372; Product type e : enzyme

DNA sequence : 
ATGACGTCGAAGACGGACGGGCCCGAGCCGGGCTTCACGGTCCGGCGCCTCGGCCCTGGCGACATCCCGTCGATGCGCGC
CCTCAACGCCCTGTTCGGACGCACCTTCGCCGAGCCCGACACCTACGGCGCCGCCCCGCCGGACGATGCCTACCTCGCGG
ACCTGCTGGCCAAGGCGCATGTTGCGGTGCTGGTGGCGGAACGTGACGGCACCGTTCTGGGTGGCCTCGTCGCCTACGAG
CTCGACAAGTTCGAGCGGGCACGGCGCGAGATCTACCTCTACGATCTCGCCGTCGAGGCCGAGCACCGCCGCCGCGGCAT
CGCCACGGCGCTGATCCGGCAGCTGCAGACCCATGCCGCGGGCCGGGGCGCCTGGGTCATCTTCGTCCAGGGCGATCCCG
GCGACGGCCCGGCGCTCGCGCTCTACGAGCGGCTCGGCACCCGCGAGGAAGTCCTGCATTTCGACCTGCCCGTCGGGGCC
CTGCCCTTGCCATTGGGAGCGAATCCCTCTAAAGGCCCGGCCTTCGCGTTCGCTCCGGCCGGGGGCTGA

Protein sequence : 
MTSKTDGPEPGFTVRRLGPGDIPSMRALNALFGRTFAEPDTYGAAPPDDAYLADLLAKAHVAVLVAERDGTVLGGLVAYE
LDKFERARREIYLYDLAVEAEHRRRGIATALIRQLQTHAAGRGAWVIFVQGDPGDGPALALYERLGTREEVLHFDLPVGA
LPLPLGANPSKGPAFAFAPAGG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
aacC1/aacCA1 ACV89836.1 type A aminoglycoside-(3)-acetyltransferase AacC1 or AacC-A1 or AAC-(3)-Ia Not tested AbaR7 Protein 3e-27 56
aacC1 AFV53117.1 aminoglycoside (3) acetyltransferase AacC1 or AacC-A1 or AAC(3)-Ia Not tested AbGRI2-1 Protein 3e-27 56
aacCA1 AGK36643.1 aminoglycoside-(3)-acetyltransferase AacC1 or AacC-A1 or AAC-(3)-Ia Not tested AbaR26 Protein 3e-27 56
aacC1/aacCA1 ACN81021.1 aminoglycoside-(3)-acetyltransferase AacC1 or AacC-A1 or AAC-(3)-Ia Not tested AbaR5 Protein 5e-27 56
aacC1/aacCA1 ACV89833.1 type A aminoglycoside-(3)-acetyltransferase AacC-A1 or AacC1 or AAC-(3)-Ia Not tested AbaR7 Protein 4e-27 56
aacC1 AFV53118.1 aminoglycoside (3) acetyltransferase AacC1 or AacC-A1 or AAC(3)-Ia Not tested AbGRI2-1 Protein 4e-27 56
aacC1 YP_005797146.1 aminoglycoside N(3')-acetyltransferase I Not tested AbaR4e Protein 5e-27 56
aacC1/aacCA1 ACN81020.1 aminoglycoside-(3)-acetyltransferase AacC-A1 or AacC1 or AAC-(3)-Ia Not tested AbaR5 Protein 5e-27 56
aac3 CAJ77083.1 Aminoglycoside 3-acetyltransferase Not tested AbaR1 Protein 4e-27 56
acc(3)Ic ACY75521.1 Aac(3) Ic Not tested Tn6060 Protein 6e-27 52
aacCA5 AAR21853.1 aminoglycoside (3) acetyltransferase; AacCA5 or AAC(3)-Ie Not tested SGI1 Protein 1e-25 48
aacCA5 AGF35061.1 aminoglycoside acetyltransferase Not tested SGI1 Protein 1e-25 48
aacCA5 AGK06931.1 aminoglycoside acetyltransferase Not tested SGI1 Protein 1e-25 48
aacCA5 AGK06968.1 aminoglycoside acetyltransferase Not tested SGI1 Protein 1e-25 48
aacCA5 AGK07014.1 aminoglycoside acetyltransferase Not tested SGI1 Protein 1e-25 48
aacCA5 AGK07072.1 aminoglycoside acetyltransferase Not tested SGI1 Protein 1e-25 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MexAM1_META1p4325 YP_002965238.1 Gentamicin 3'-N-acetyltransferase NC_010410.6002585.p0 Protein 2e-27 56
MexAM1_META1p4325 YP_002965238.1 Gentamicin 3'-N-acetyltransferase NC_011586.7045205.p0 Protein 2e-27 56
MexAM1_META1p4325 YP_002965238.1 Gentamicin 3'-N-acetyltransferase AF318077.1.gene3.p01 Protein 2e-27 55
MexAM1_META1p4325 YP_002965238.1 Gentamicin 3'-N-acetyltransferase U04610.gene.p01 Protein 5e-27 55