Gene Information

Name : merA (MexAM1_META1p2635)
Accession : YP_002963682.1
Strain : Methylobacterium extorquens AM1
Genome accession: NC_012808
Putative virulence/resistance : Resistance
Product : mercuric reductase (MerA)
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 2765528 - 2766967 bp
Length : 1440 bp
Strand : +
Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme

DNA sequence : 
ATGAGCGATTGCTGCAGCACCCCGCGCGGGAACAACGGCAGCGGCCCCTACGACCTCGTCGTCGTCGGCGCCGGTTCGGC
CGGGTTCTCGGCCGCGATCACGGCCGCCGAGCAGGGCGCACAGGTCGCCCTCATCGGGCACGGCACGTTGGGCGGCAGCT
GCGTGAACGTGGGCTGCGTCCCCTCGAAGGCCCTGATCCGGGCCGCGGAGACCGTGCACCATGCCAACACCGCGGGCGGC
CGGTTCGCGGGCATCCAGGCCCAGGCTCGGGTGACCGACTGGCGCGCCCAGGTCGCCCAGAAGGACGCCCTGGTGCAGGG
CCTGCGCCAGGCGAAGTACGCGGACCTCCTGCCGGCCTACAACAACGTGTCCTACCACGAGGGTCGCGCGCGCCTCGTCG
CCGGCGGGGTCGAGGCAGGGGGCCGGCATTTCGCGGCGAATCGCATCCTCATCGCCACGGGCACGCGCCCGGCCATGCCG
AACATTCCCGGCCTTGCCGACGCCTCGCCCCTCGACAGCACCGCGGCGCTTGCCCTCACCGAACTTCCGCGCTCGATGAT
CGTCCTCGGCGGCGGCTACATCGGCGCGGAGCTTGCGCAGACCTTCGCGCGGGTCGGGGTCGCCGTGACGCTCGTCTGCC
GCAGCCGGCTCCTGCCCGCGGCGGAGCCGGAGATCGGGGAGGCCCTCGCCGGCTATCTGGCCGGCGAAGGCATCGCCGTT
CTGGGCGGCCTGTCCTACGAGGCCGTGGACAGGACGGAGGGTGGCGTGAGCCTTACGTTCTGGCGGGACGGCCGCCGGGA
GACCGTCACGGCCGAGCGGATCCTGGCGGCGACCGGGCGCACCGCGAATACCGAGGACCTCGGTCTCGCCGACGCGGGTG
TCGCCCAGACGCCGACGGGCGCCATCGTGGTCGACGACCGCATGCGCACCTCGAAGCCGGGCATCTACGCTGCCGGCGAC
GTCACCGGGAAGGACCAGTTCGTCTACATGGCGGCCTACGGCGCGAAACTGGCCGCCAAGAACGCCCTCAACGGCGACAG
CCTGCGCTACGACAACAGGGCGATGCCGGCCGTGGTGTTCACCGACCCTCAGGTCGGAAGCGTCGGCCTCACCGAGGTGC
AGGCCCGGGCGGCCGGGTACGACGTGCGCACCTCGGTGCTCACGCTCGACAACGTGCCCCGCGCGCTCGCGGCGCGCGAC
ACGCGCGGGCTGATCAAGCTCGTGGCGGATCGCGCGACCCGGCAGCTGTTGGGAGCGCATATCCTGGCCCCCGAGGGCGC
GGACAGCATCCAGACGGCGGCGATGGCCATCCGCGGCGGGCTGACCATCGACGCGCTCGCGGAGACGATCTTCCCATACC
TGACCACCGTCGAGGGTCTCAAGCTCGCGGCCCAGACCTTCGACAGGGACGTCAGGAAATTGTCCTGCTGCGCCGGTTAA

Protein sequence : 
MSDCCSTPRGNNGSGPYDLVVVGAGSAGFSAAITAAEQGAQVALIGHGTLGGSCVNVGCVPSKALIRAAETVHHANTAGG
RFAGIQAQARVTDWRAQVAQKDALVQGLRQAKYADLLPAYNNVSYHEGRARLVAGGVEAGGRHFAANRILIATGTRPAMP
NIPGLADASPLDSTAALALTELPRSMIVLGGGYIGAELAQTFARVGVAVTLVCRSRLLPAAEPEIGEALAGYLAGEGIAV
LGGLSYEAVDRTEGGVSLTFWRDGRRETVTAERILAATGRTANTEDLGLADAGVAQTPTGAIVVDDRMRTSKPGIYAAGD
VTGKDQFVYMAAYGAKLAAKNALNGDSLRYDNRAMPAVVFTDPQVGSVGLTEVQARAAGYDVRTSVLTLDNVPRALAARD
TRGLIKLVADRATRQLLGAHILAPEGADSIQTAAMAIRGGLTIDALAETIFPYLTTVEGLKLAAQTFDRDVRKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AGK07021.1 MerA Not tested SGI1 Protein 3e-75 48
merA AGK07079.1 MerA Not tested SGI1 Protein 3e-75 48
merA ABQ57371.1 MerA Not tested SGI1 Protein 3e-75 48
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 4e-74 48
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 5e-75 48
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 3e-74 48
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 1e-72 47
merA AFG30120.1 MerA Not tested PAGI-2 Protein 1e-72 47
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 2e-72 47
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 8e-74 46
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 1e-83 45
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 7e-84 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_002963682.1 mercuric reductase (MerA) BAC0652 Protein 7e-75 47
merA YP_002963682.1 mercuric reductase (MerA) BAC0653 Protein 2e-74 47
merA YP_002963682.1 mercuric reductase (MerA) BAC0224 Protein 3e-80 46
merA YP_002963682.1 mercuric reductase (MerA) BAC0651 Protein 5e-84 45
merA YP_002963682.1 mercuric reductase (MerA) BAC0650 Protein 2e-68 44
merA YP_002963682.1 mercuric reductase (MerA) BAC0649 Protein 4e-64 41