Gene Information

Name : cpkA (TGAM_0120)
Accession : YP_002958486.1
Strain : Thermococcus gammatolerans EJ3
Genome accession: NC_012804
Putative virulence/resistance : Unknown
Product : carbamate kinase-like carbamoyl phosphate synthetase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0549
EC number : 2.7.2.2
Position : 111052 - 112002 bp
Length : 951 bp
Strand : -
Note : this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable react

DNA sequence :
GTGATACTAATGAAGAGGGTCGTCATAGCCCTTGGCGGTAACGCAATCCTCCAGCGAGGTCAAAGGGGAACCTACGAGGA
GCAGATGGAGAACGTGAGAAAGACGGCGAAGCAGATAGCTGACATAATCGAGAGGGGCTACGAGGTCGTTATAACTCACG
GAAACGGTCCCCAGGTTGGCGCACTACTCCTCCACATGGACGCGGGCCAGCAGCTCTACGGCATACCGGCCCAGCCGATG
GACGTGGCCGGTGCGATGACGCAGGGACAGATCGGGTACATGATAGGGCAGGCCCTAATCAATGAGCTCAGAAAACGCGG
TATAGACAGGCCAGTTGCGACGATAGTAACCCAGACGATTGTGGACAAGAATGACCCCGCCTTTAAGAACCCGAGCAAGC
CCGTCGGGCCCTTCTACGACGAGGAGACGGCGAAGAAGCTGGCCAAGGAGAAGGGCTGGGTGGTCATCGAGGATGCGGGA
AGGGGCTGGAGGCGTGTTGTTCCGAGTCCCGATCCCAAGGGCCACGTTGAAGCCCCGGTGATCCAGGATCTCGTGGAGAA
GGGCTTCATAGTCATCGCGAGCGGTGGCGGTGGCGTTCCCGTCATAGAGGAGAATGGAGAGCTTAAAGGCGTCGAGGCTG
TCATAGACAAGGATTTGGCGGGGGAAAAGCTGGCCGAGGAGGTCAAGGCGGATATCTTCATGATTCTCACCGACGTCAAC
GGTGCCGCGATAAACTTCGGGAAGCCGGACGAGAGGTGGCTTGAGAGGGTCACCGTCGAGGAGCTCAGGAAGTACTACGA
AGAGGGACACTTCAAGAGGGGCAGCATGGGTCCGAAGGTTCTGGCCGTCATAAGATTCCTTGAGTGGGGCGGTGAAAGGG
CGATAATAGCCTCGCTCGACAGGGCCGTTGAAGCCCTCGAAGGGAAGACGGGAACGCAGGTTTTTCCCTGA

Protein sequence :
MILMKRVVIALGGNAILQRGQRGTYEEQMENVRKTAKQIADIIERGYEVVITHGNGPQVGALLLHMDAGQQLYGIPAQPM
DVAGAMTQGQIGYMIGQALINELRKRGIDRPVATIVTQTIVDKNDPAFKNPSKPVGPFYDEETAKKLAKEKGWVVIEDAG
RGWRRVVPSPDPKGHVEAPVIQDLVEKGFIVIASGGGGVPVIEENGELKGVEAVIDKDLAGEKLAEEVKADIFMILTDVN
GAAINFGKPDERWLERVTVEELRKYYEEGHFKRGSMGPKVLAVIRFLEWGGERAIIASLDRAVEALEGKTGTQVFP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
APECO1_2636 YP_859422.2 carbamate kinase Not tested Not named Protein 2e-60 49
SAKOR_01091 YP_008491279.1 Carbamate kinase Not tested vSa¥ã Protein 1e-61 46
SE0102 NP_763657.1 carbamate kinase Not tested SCCpbp4 Protein 7e-60 46
arcC1 YP_186045.1 carbamate kinase Not tested vSa¥ã Protein 5e-61 46
MW1051 NP_645868.1 carbamate kinase Not tested vSa¥ã Protein 5e-61 46
SAV1170 NP_371694.1 carbamate kinase Not tested vSa¥ã Protein 5e-61 46
SA1013 NP_374286.1 carbamate kinase Not tested vSa¥ã Protein 5e-61 46
arcC YP_493761.1 carbamate kinase Not tested vSa¥ã Protein 5e-61 46