Gene Information

Name : Mlut_06150 (Mlut_06150)
Accession : YP_002956706.1
Strain : Micrococcus luteus NCTC 2665
Genome accession: NC_012803
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 672864 - 674288 bp
Length : 1425 bp
Strand : +
Note : PFAM: Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: mercuric reductase

DNA sequence : 
ATGCCCACGAAGTACGACCTCGCTATCATCGGATCGGGCGGTGGTGCGTTCGCCGCCGCGATCCGCGCGACCACGCTCGG
CAAGTCGGTGGTGATGATCGAGCGCGGGACGCTGGGCGGCACCTGCGTGAACACCGGCTGCGTGCCGTCGAAGGCCCTGA
TCGCCGCGGCCGACGCACGGCACTCCGCGGCCGACGCCGCCGACCGGTTCCCGGGGATCGCGACGACGGCGGGGCCGGTG
GACATGCCCGCCCTGATCGCCGGGAAGCAGGCGCTGGTCGAGTCGCTGCGGGGCGAGAAGTACGCCGACGTCGCCGACTC
CTACGGGTGGGCCGTCCGCCGCGGCGACGCCGCGTTCGCCGGCACCCCCGACGCTCCGGTCCTCCAGGTCGCCGGGGACG
ACGGCAGCACCGAGACGATCGAGGCCGGGCACTTCCTGGTGGCGACCGGCTCTCGGCCGTGGGCCCCGCCGATCGACGGC
CTGGACGAGACCGGGTACCTGACCTCGACCACGGCGATGGAGCTGACCGAACTCCCTGAGTCCCTGCTCGTGCTCGGCGG
CGGCTACGTCGCCCTGGAGCAGGCGCAGCTGTTCGCCCGGCTCGGCTCCCAGGTCACCGTGCTGGTCCGGTCCCGGCTCG
CGTCGAAGGAGGAGCCGGAGGTGTCCAGGACGCTGGAGGAGGTGTTCGCCGACGAGGGCATCCGGGTGGTCCGCCGCGCG
CTGCCGACGCGGGTGTCCCGCGACGCCGCGACCGGGCAGGCCGTCGTCACCGCGGACGTCGCCGGGGGGCGGGAGGAGTT
CCGCGCCGACCAGGTGCTCGTCGCCCTCGGACGACGACCGGTCACCGACGGGCTCGGCCTCGACAGGGTCGGGGTCGAGA
CCGGGGACCTCGGCGAGGTGGTCGTCTCCGACCGGATGCAGTCCTCCCACCCGCGGATCTGGGCCGCGGGCGACGTGACC
GGCCACCCTGAGTTCGTCTACGTCGCCGCCCACCACGGCACCCTCGTCGCCGAGAACGCGTTCGCCGACGCCGACCGGGC
CGTGGACTACGCCCGACTGCCGAGGGTGACGTTCACCGGCCCGGCGATCGGCGCGGTCGGGATGACCGAGAAGGACGTCG
TCGCCGCCGGGATCCGCTGCGACTGCCGCGTCCTGCCGCTGCACCACGTGCCCCGCGCACTGGTCAACCGCGACACCCGC
GGCTTCGTCAAGATCGTCGTGGACGCCGACACCGGGAAGATTCTCGGCATCACCGCCGTCGCCAAGGACGCCGGCGAGCT
CGCCGCCGCCGGGGTCCACGTGCTCGGCAAGACGGTCGCCGAGGTCGCCGACGCCTGGGCCCCCTACCTGACCATGGCCG
AGGGCATCCGGATCGCCGCCAAGGCCTTCACCACCGATCCGTCGCTCCTGTCGTGCTGCGCGTGA

Protein sequence : 
MPTKYDLAIIGSGGGAFAAAIRATTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAADARHSAADAADRFPGIATTAGPV
DMPALIAGKQALVESLRGEKYADVADSYGWAVRRGDAAFAGTPDAPVLQVAGDDGSTETIEAGHFLVATGSRPWAPPIDG
LDETGYLTSTTAMELTELPESLLVLGGGYVALEQAQLFARLGSQVTVLVRSRLASKEEPEVSRTLEEVFADEGIRVVRRA
LPTRVSRDAATGQAVVTADVAGGREEFRADQVLVALGRRPVTDGLGLDRVGVETGDLGEVVVSDRMQSSHPRIWAAGDVT
GHPEFVYVAAHHGTLVAENAFADADRAVDYARLPRVTFTGPAIGAVGMTEKDVVAAGIRCDCRVLPLHHVPRALVNRDTR
GFVKIVVDADTGKILGITAVAKDAGELAAAGVHVLGKTVAEVADAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 7e-69 45
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 8e-84 44
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 6e-84 44
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-67 43
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-67 43
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-67 43
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 7e-67 43
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 3e-65 43
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-65 43
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-65 43
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 7e-67 43
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 6e-65 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mlut_06150 YP_002956706.1 mercuric reductase BAC0651 Protein 4e-84 44
Mlut_06150 YP_002956706.1 mercuric reductase BAC0652 Protein 1e-68 44
Mlut_06150 YP_002956706.1 mercuric reductase BAC0224 Protein 5e-82 44
Mlut_06150 YP_002956706.1 mercuric reductase BAC0653 Protein 2e-64 41