Gene Information

Name : GWCH70_0802 (GWCH70_0802)
Accession : YP_002948954.1
Strain : Geobacillus sp. WCH70
Genome accession: NC_012793
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 866275 - 867459 bp
Length : 1185 bp
Strand : +
Note : catalyzes the formation of L-homocysteine from cystathionine

DNA sequence :
ATGGAACAACACGTATCTTTTCAAACGAAACTGCTCCATAATAAATGGAAAATGGATCCTCAAACGGGAGCGGTCAGTGT
GCCGATTCAGCACGCTTCCACGTTCCATCAATTTGATTTTGATACATTCGGCAAATATGATTATAGCCGCTCAGGCAATC
CGACGCGCGAAGCGTTGGAAGAGACGATTGCGGCGTTAGAAGGAGGGGTGCGCGGTTTCGCCTTCTCATCCGGAATGGCG
GCGATTTCCACCGCTTTTCTCCTCTTGTCCAAAGGCGATCATGTGCTTGTGACGGAAGACGTTTACGGCGGTACGTACCG
AATGATTACCGAGGTATTGAGCCGCTTTGGCATTGAATATACGTTCGTTGATATGACGGATTTGCATGAAGTAGCTTCCC
ATATTCGCCCGAATACAAAAGTCATTTACGTTGAAACCCCATCGAATCCGCTTTTAAAAGTGACCGATATTCGCGGGATT
GTGAAGCTTGCAAAGGCAAATGGCTGTTTAACGTTTTTAGATAATACGTTTATGACTCCCGCTCTGCAGCGTCCGCTCGA
TCTTGGTGTCGATGTCGTCCTTCATAGCGCGACGAAATTTTTATCGGGGCATAGCGACGTTGTTGCCGGGCTTGCCGTTG
TCAAAGACGAGGAACTTGCCAAACAGCTGTACAAATTGCAAAACTCTTTCGGAGCGGTGCTCGGCGTCCAAGACGCATGG
CTTGTGTTGCGCGGATTAAAAACGCTTCATGTCCGCCTCGAGCAATCATCGCAGTCAGCGCTAAAGATAGCCCGTTATTT
AGCGAATCATCCGAAAGTGGAAGAAGTGTATTATCCAGGGCTTACGTATCATCCGGGCCATGCGATTCAGCGCTATCAGG
CATCAGGATTTGGCGCGGTATTATCGTTCCGCCTTGCCGATGAAGAAGCGGTCCGGACGTTTGTAAAGCATGTTCGCATC
CCTGTATTTGCCGTCAGCTTAGGAGCAGTCGAATCGATTTTATCGTATCCTGCCAAAATGTCACATGCGGCGATGCCGAA
AGAAGAACGGGAGCGGCGCGGCATCACGGACGGCTTGCTGCGTCTTAGTGTTGGCCTTGAAGCCGCTGACGATCTAATTG
CCGATTTCGAGCAAGCACTGTCATATGTCAAAGAAACATCATCATCCACTGTTTCAGCACGATAA

Protein sequence :
MEQHVSFQTKLLHNKWKMDPQTGAVSVPIQHASTFHQFDFDTFGKYDYSRSGNPTREALEETIAALEGGVRGFAFSSGMA
AISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLSRFGIEYTFVDMTDLHEVASHIRPNTKVIYVETPSNPLLKVTDIRGI
VKLAKANGCLTFLDNTFMTPALQRPLDLGVDVVLHSATKFLSGHSDVVAGLAVVKDEELAKQLYKLQNSFGAVLGVQDAW
LVLRGLKTLHVRLEQSSQSALKIARYLANHPKVEEVYYPGLTYHPGHAIQRYQASGFGAVLSFRLADEEAVRTFVKHVRI
PVFAVSLGAVESILSYPAKMSHAAMPKEERERRGITDGLLRLSVGLEAADDLIADFEQALSYVKETSSSTVSAR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-89 54
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-84 50
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-86 50

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GWCH70_0802 YP_002948954.1 cystathionine beta-lyase BAC0207 Protein 4e-62 41