Gene Information

Name : GWCH70_0801 (GWCH70_0801)
Accession : YP_002948953.1
Strain : Geobacillus sp. WCH70
Genome accession: NC_012793
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 865167 - 866270 bp
Length : 1104 bp
Strand : +
Note : catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity

DNA sequence :
ATGGAGAAAATGGAAACGTTATTGGCGCAAATCGGAAACCGCAGTGACACGGTCACAGGAACGGTCAATCCGCCCGTCTA
TTTTTCGACCGCGTACCGTCATGAAGGAATCGGGAAGTCTACCGGATTTGACTACATTCGTACCGGCAATCCGACGCGGA
AAATCGTCGAGGAAGCGATCGCAAAGCTAGAAGGAGGAGACCAAGGCTACGCGTTCAGCTCGGGCATGGCGGCCATTCAG
ACGGTTCTTGCGTTATTTGAAAGCGGGGATGAATTTCTCGTTTCCTCCGATTTATATGGAGGTACATATCGTTTATTTGA
ACGCGGCTGGCGAAAATACGGCTTGTCTTTTCATTATGTAGATTTTCGCGACATACGATTAGTAGAGAACTACATCACTG
AAAAAACAAAAGCGATTTTTTTAGAAACACCGACGAACCCGTTAATGCAGGAAACGGACATTGCTGAAGTGGCAAAATTT
GCGAAAAAACATGGACTGCTTCTCATTGTCGACAACACGTTTTACACACCAGTTTTTCAGCGTCCGATCGAGCAAGGAGC
CGATATCGTCATCCATAGTGCGACAAAATATTTAGGCGGCCATAACGATGTGTTGGCAGGTCTCGTCGTTGCGAAGGGGG
AGGAACTTTGCAAGCGGCTTGCGGAATATCAGAACGCAATTGGCGCTGTGCTTTCACCGTTTGATTCATGGCTGCTTATT
CGCGGCATGAAGACGCTGGCGCTTCGGATGCGACAGCACGAAGAAAACGCGAAGCGAATCAGTGAATTTTTAGCGGCGCA
TGAAGATATTACTGATGTATTATACCCGGGAAGAGGCGGCATGTTATCGTTTCGTTTGCGCGAAGAAAAATGGGTCAACC
GCTTTTTGCAAAGTTTACGATTAATTACATTCGCCGAAAGTTTAGGAGGAGTTGAAAGTTTTATTACGTATCCAGCAACG
CAAACCCATGCCGATATTCCAGAAGAAATCCGCATCGCCAACGGTGTCTGTAACCGGCTGCTTCGTTTCTCTGTCGGCAT
CGAGCATGTCGAAGATTTAATTTCTGACTTATCGCAAGCGTTAAAAAGTATGAAAGAGGTGTAG

Protein sequence :
MEKMETLLAQIGNRSDTVTGTVNPPVYFSTAYRHEGIGKSTGFDYIRTGNPTRKIVEEAIAKLEGGDQGYAFSSGMAAIQ
TVLALFESGDEFLVSSDLYGGTYRLFERGWRKYGLSFHYVDFRDIRLVENYITEKTKAIFLETPTNPLMQETDIAEVAKF
AKKHGLLLIVDNTFYTPVFQRPIEQGADIVIHSATKYLGGHNDVLAGLVVAKGEELCKRLAEYQNAIGAVLSPFDSWLLI
RGMKTLALRMRQHEENAKRISEFLAAHEDITDVLYPGRGGMLSFRLREEKWVNRFLQSLRLITFAESLGGVESFITYPAT
QTHADIPEEIRIANGVCNRLLRFSVGIEHVEDLISDLSQALKSMKEV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-72 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-73 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GWCH70_0801 YP_002948953.1 cystathionine gamma-synthase BAC0207 Protein 2e-58 41