Gene Information

Name : thyA (GWCH70_1581)
Accession : YP_002949642.1
Strain : Geobacillus sp. WCH70
Genome accession: NC_012793
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1653666 - 1654460 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
TTGCGTCAATACTTACAATTACTAGAAGATATTCTCGAAAACGGAGTAGAAAAAGACGACCGTACTGGGGTCGGGACGTT
ATCCGTGTTTGGTCGTCAGCTGCGTTTTAATTTGCAGGAAGGATTCCCACTCTTAACAACTAAAAAATTACATATCCGTT
CGATCATTTACGAATTATTATGGTTTTTAAAAGGAGATACGAATGTTCGTTATTTGCAGGAAAACGGCGTGACGATCTGG
GATGAGTGGGCGGATGAAAACGGTGATTTAGGCCCGATATACGGCGCGCAGTGGCGTTCATGGAAAGGGGCCGATGGCAA
AACGGTGGATCAAATCAGCTGGGTTATTGAAGAAATTAAACGAAACCCAAATTCCCGCCGCTTATTAGTAAGCGCGTGGA
ATGTGGCAGAGCTAGATAAAATGAAACTGCCGCCTTGCCATTATGCGTTTCAATTTTATGTGGCAGACGGGAAGCTTTCT
TGCATGTGGCAGCAACGTTCCGTTGATACGTTTTTAGGTTTGCCGTTTAACATCGCCAGCTATGCGCTGTTGACGCATAT
GATCGCCCAGCAGTGCGATTTAGATGTCGGCGAATTGATTTTTAGCGGCGGCGATGTACATTTGTATAAAAATCATCTTG
AGCAAGCCAAACTACAACTGACGAGAGAACCGCGACCGCTTCCGAAGCTGGTGATCAAGCGGAAGCCTGCTTCGATTTTT
GAATATGAATTCGAGGATTTTGAAATTGTCGACTATGATCCTCATCCGCATATTAAAGCGCCGGTTGCCGTATAA

Protein sequence :
MRQYLQLLEDILENGVEKDDRTGVGTLSVFGRQLRFNLQEGFPLLTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIW
DEWADENGDLGPIYGAQWRSWKGADGKTVDQISWVIEEIKRNPNSRRLLVSAWNVAELDKMKLPPCHYAFQFYVADGKLS
CMWQQRSVDTFLGLPFNIASYALLTHMIAQQCDLDVGELIFSGGDVHLYKNHLEQAKLQLTREPRPLPKLVIKRKPASIF
EYEFEDFEIVDYDPHPHIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-79 64