Gene Information

Name : spaP (HDEF_1506)
Accession : YP_002924278.1
Strain : Candidatus Hamiltonella defensa T5A
Genome accession: NC_012751
Putative virulence/resistance : Virulence
Product : surface presentation of antigens protein SpaP
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4790
EC number : -
Position : 1379991 - 1380656 bp
Length : 666 bp
Strand : +
Note : part of a type III secretory system probably involved in invasion into eukaryotic cells

DNA sequence :
ATGGACAATGACATTTCACTCATTTCAATTCTTGCATTTTCAACATTATTACCCTTCGTCATCGCATCAGGCACTTGCTA
TATCAAATTTTCGATTGTGTTTGTGATGGTCAGAAATGCCCTCGGATTGCAGCAGATCCCGTCAAATATGACCCTCAATG
GTGTCGCTTTGCTGTTAGCCAGTTTTGTGATGATGCCTATTGTCAAAAACATCTATGAAGGCCATAAAAATGCACAATTC
GATGTCAGAAACCTTTCCTCGGTGATCGAATTCGTTGAAAATGGTCTCGATGGCTATCGTTCTTATCTTGTCAAATATGC
AGATCCAGAGTTAACCCAATTTTTTGAAAAAGCCGCCTCTGACAGAAAGGAAGAAGATTTTGCTGGTGCCGAAGAGGAAA
AACCCTCTATCTTTGCTCTTTTGCCTGCATACGCGTTAAGCGAAATCAAAAGCGCATTTAAAATTGGTTTTTACATTTAT
TTGCCCTTTGTGGTGGTTGATTTATTGATATCCAGCATTCTACTGGCGTTGGGGATGATGATGATGAGCCCTGTCACCAT
TTCTGTGCCGATCAAACTGGTCTTATTTGTTGTATTAGATGGCTGGACCCTGATTTCTAAAGGAATGATTTTACAATATA
TGGATTTAGCTGGAGCCAGCTCTTGA

Protein sequence :
MDNDISLISILAFSTLLPFVIASGTCYIKFSIVFVMVRNALGLQQIPSNMTLNGVALLLASFVMMPIVKNIYEGHKNAQF
DVRNLSSVIEFVENGLDGYRSYLVKYADPELTQFFEKAASDRKEEDFAGAEEEKPSIFALLPAYALSEIKSAFKIGFYIY
LPFVVVDLLISSILLALGMMMMSPVTISVPIKLVLFVVLDGWTLISKGMILQYMDLAGASS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
spaP NP_457284.1 secretory protein (associated with virulence) Virulence SPI-1 Protein 1e-59 71
spaP NP_806493.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 1e-59 71
spaP YP_217809.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 4e-60 71
spaP NP_461811.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 4e-60 71
spaP NP_311752.1 surface presentation of antigens protein SpaP Not tested LIM Protein 7e-64 68
epaP AAZ31293.1 EpaP Virulence ETT2 Protein 6e-62 67
spaP AAS66865.1 SpaP Not tested SSR-2 Protein 9e-63 64
ysaR AAS66846.1 YsaR Not tested SSR-1 Protein 6e-55 59
lscR AAO18040.1 LscR Virulence TTSS locus Protein 1e-30 44
ECs4583 NP_312610.1 type III secretion system protein Virulence LEE Protein 1e-30 43
escR AAC38369.1 EscR Virulence LEE Protein 8e-30 43
escR AAC31528.1 L0049 Virulence LEE Protein 1e-30 43
escR ACU09473.1 type III secretion system protein EscR Virulence LEE Protein 1e-30 43
escR YP_003236103.1 T3SS structure protein EscR Virulence LEE Protein 2e-30 43
escR AAK26700.1 EscR Virulence LEE Protein 1e-30 43
escR NP_290283.1 type III secretion system protein Virulence LEE Protein 2e-30 43
escR AAL57527.1 EscR Virulence LEE Protein 1e-30 43
escR YP_003223490.1 T3SS structure protein EscR Virulence LEE Protein 2e-30 43
escR CAC81847.1 EscR protein Virulence LEE II Protein 1e-30 43
escR YP_003232138.1 type III secretion system protein Virulence LEE Protein 2e-30 43
escR CAI43889.1 EscR protein Virulence LEE Protein 1e-30 43
escR AFO66317.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-27 42
escR AFO66400.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-27 42
unnamed AAL06354.1 EscR Virulence LEE Protein 1e-28 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG0551 Protein 2e-60 71
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG1773 Protein 2e-60 63
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG1012 Protein 7e-56 62
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG2455 Protein 1e-55 57
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG0394 Protein 4e-32 44
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG0715 Protein 4e-30 43
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG0827 Protein 7e-31 43
spaP YP_002924278.1 surface presentation of antigens protein SpaP VFG0188 Protein 7e-31 42