Gene Information

Name : invA (HDEF_1499)
Accession : YP_002924271.1
Strain : Candidatus Hamiltonella defensa T5A
Genome accession: NC_012751
Putative virulence/resistance : Virulence
Product : type III needle complex export protein
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4789
EC number : -
Position : 1373636 - 1375690 bp
Length : 2055 bp
Strand : +
Note : COG4789

DNA sequence :
ATGAATAAATTTTTAGAAAATGTACGGAACCGACCAGAGTTATTGATCCTCGCTTTAGTCATCATGATTATTGCGATGCT
GATCATCCCTCTACCAACTTATCTTGTTGATTTTTTAATCGGGCTCAATATCGTGATTTCCTTATTGGTATTTATGGGAT
CCTTCTACATTGACCGAATTCTAAATTTTTCTACTTTCCCTGCGGTTTTGTTGATTACCACTTTATTTCGGCTCGCTTTG
TCGATTAGTACCAGCCGATTGATATTAAATGACGCGGATGCCGGAGAAATCGTGCGCACATTCGGGTTATTTGTCATCGG
CGATAATTTAGTGGTCGGTTTTGTTATTTTTGGGATCGTCACCATTGTGCAATTTATCGTCATTACAAAAGGGGCAGAAC
GTGTTGCTGAAGTCGCCGCCCGTTTTTCTCTTGATGCTATGCCTGGTAAACAGATGAGTATCGATGCGGATTTGAAAGCG
GGCGTCATTGATTCCGATGCTGCCAAAGAACGGCGATCTGTTTTAGAAAAAGAAAGCCAGCTGTATGGTTCCTTTGACGG
TGCGATGAAATTTATTAAAGGAGATGCGATTGCAGGTATTATCGTTATTTTTATCAACTTTATCGGGGGGATAAGTGTGG
GTGTCAGCCAGCATGGTATGAGTATGTCATCGGCGCTTTCTACTTATACCATGTTGACCATAGGAGACGGCCTGGTAGCT
CAAATCCCTTCATTATTGATTGCAATCAGTGCCGGTTTTATCGTGACCCGAGTAAATGGGGACGGTGACAACATGGGTCG
TACCATGATGAGTCAATTAGTATCAAACCCATTTGCGTTGATGGTTACGGCAGGATTAGCATTGACCATTGGGTTTTTAC
CCGGCTTTCCTCTATTTGTTTTTGTCATTTTAGCCGGTGTTTTAAGTGGATTTTTTATATACAAACATTTCTTTGAAAAA
AAGAAAGGCACAGAGGCTTTAGAAAAAGCTGATAGTAAAGAAGAAGATAGCGTATTTAATGAGACACATTCTATTGACAG
TTCTTTGGGGCTGATTGGTAATTTAGATAAAGTTTCATCCGAAACCGTACCTTTTATTATGCTGGTGTCTTCTTCTGATT
TAGAAAAATTAGAAAATCAAAAATTAGTAGAGCATTTACGTAGCCAATTCTTTATTGATTATGGTATTCGTCTCCCTAAC
ATCTTGTTAAGGGCATCGACTACCGTATCAAAAAATCGAGCTGTTTTCTTGATCAATGAAATTCGAGCAGAAGAATTTGT
ACTTCAGCTTGATTTATTGAGAATCGTCAACAGCTCAGATGAGCTTATGCAACTAGAGATAGAGACTGTGCTCGATAACG
GTACTGTCTGGGTGAAACCTGAACATAAAGAAACACTGGAAAATATGGGGTATCAATTACGTTCACCAATAGATGAACTT
TATCACAGCATGGCAGCTTTACTGTCTCGTCATGTAAGCGAATATTTTGGTATCCAGGAAACGAAAGACATGTTGGATAA
ACTGGAAAATAAATATCCTGATTTAATGAAAGAAATTATGAGGCACGCCACAATACAAAGGATTACCGAAGTACTACAGC
GTTTACTCTCTGAACGTATTTCGGTTCGTAATATGCGGCTGATTATGGAATCTTTAGCTTTATGGATGCCTCGTGAAAAA
GATGTCATCTCGTTAGTCGAACATGTTCGTGGTGGACTATCTCGATACATCTGTCATAAATTTTCTGTCAATAATGAACT
CAGGTCGATCGTTTTATCATCAGAAGTGGAAGATATGATACGTCAAGGAATAAGAAACACATCAGGGGGGACTTTTCTTA
ATTTAGAGCCTGCGGTATCTGATCAATTAATGGATTTATTTTCTGTTAATTTAGAAAATTTATTGATTGATCATAAAGAT
TTAGTCCTTTTATCATCGGTTGACACCCGACGTTTTGTTAAAAAATTTATAGAGTCTCGTTTTCGAGATTTAGAAGTGAT
GTCATTTGGAGAAATCTCTGAAACGGTCTCTGTAAATGTTCTTAAAACCATTTAA

Protein sequence :
MNKFLENVRNRPELLILALVIMIIAMLIIPLPTYLVDFLIGLNIVISLLVFMGSFYIDRILNFSTFPAVLLITTLFRLAL
SISTSRLILNDADAGEIVRTFGLFVIGDNLVVGFVIFGIVTIVQFIVITKGAERVAEVAARFSLDAMPGKQMSIDADLKA
GVIDSDAAKERRSVLEKESQLYGSFDGAMKFIKGDAIAGIIVIFINFIGGISVGVSQHGMSMSSALSTYTMLTIGDGLVA
QIPSLLIAISAGFIVTRVNGDGDNMGRTMMSQLVSNPFALMVTAGLALTIGFLPGFPLFVFVILAGVLSGFFIYKHFFEK
KKGTEALEKADSKEEDSVFNETHSIDSSLGLIGNLDKVSSETVPFIMLVSSSDLEKLENQKLVEHLRSQFFIDYGIRLPN
ILLRASTTVSKNRAVFLINEIRAEEFVLQLDLLRIVNSSDELMQLEIETVLDNGTVWVKPEHKETLENMGYQLRSPIDEL
YHSMAALLSRHVSEYFGIQETKDMLDKLENKYPDLMKEIMRHATIQRITEVLQRLLSERISVRNMRLIMESLALWMPREK
DVISLVEHVRGGLSRYICHKFSVNNELRSIVLSSEVEDMIRQGIRNTSGGTFLNLEPAVSDQLMDLFSVNLENLLIDHKD
LVLLSSVDTRRFVKKFIESRFRDLEVMSFGEISETVSVNVLKTI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
invA YP_217815.1 invasion protein Virulence SPI-1 Protein 0.0 69
invA NP_457290.1 possible secretory protein (associated with virulence) Virulence SPI-1 Protein 0.0 69
invA NP_806499.1 virulence-associated secretory protein Virulence SPI-1 Protein 0.0 69
invA NP_461817.1 needle complex export protein Virulence SPI-1 Protein 0.0 69
ECs3731 NP_311758.1 EivA Not tested LIM Protein 3e-180 61
invA AAS66860.1 InvA Not tested SSR-2 Protein 4e-179 60
ysaV AAS66840.1 YsaV Not tested SSR-1 Protein 1e-152 53
lssD AAO18050.1 LssD Virulence TTSS locus Protein 3e-108 43
unnamed AAL06368.1 EscV Virulence LEE Protein 3e-89 41
YPO0266 YP_002345347.1 secretion system apparatus protein SsaV Virulence Not named Protein 9e-98 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
invA YP_002924271.1 type III needle complex export protein VFG0557 Protein 0.0 69
invA YP_002924271.1 type III needle complex export protein VFG1006 Protein 0.0 63
invA YP_002924271.1 type III needle complex export protein VFG2461 Protein 6e-157 56
invA YP_002924271.1 type III needle complex export protein VFG1780 Protein 3e-154 55
invA YP_002924271.1 type III needle complex export protein VFG0384 Protein 3e-107 43
invA YP_002924271.1 type III needle complex export protein VFG0198 Protein 2e-106 43
invA YP_002924271.1 type III needle complex export protein VFG0064 Protein 2e-104 42