Gene Information

Name : ssaV (HDEF_0129)
Accession : YP_002923050.1
Strain : Candidatus Hamiltonella defensa T5A
Genome accession: NC_012751
Putative virulence/resistance : Virulence
Product : secretion system apparatus protein SsaV
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4789
EC number : -
Position : 133889 - 135937 bp
Length : 2049 bp
Strand : -
Note : with SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system

DNA sequence : 
ATGGTCATGAGAGGAGATAAAATAAAAAAAGCGCTGGCTTTACTGTTAGAGCGGCAAGATATTTTTTTAGCGGTCATGTT
GCTTGTCGCCATCTTTATGATGATTTTGCCATTACCCACAGAATTGATCGATGTCTTGATTGCCGTCAATCTGGGGCTTT
CTGCTATTTTACTGATGATTTCTATTTACATTCGGGATCCACTTGAATTTTCAGTATTCCCTTCTTTATTGCTGATCACC
ACTTTATATCGCCTTGCCTTAACCATCAGTACCAGCCGTTTAGTATTACTACAACATGATGCAGGCGAAATTGTTGAAGC
TTTTGGACAATTTGTTGTGGGCGGTAATCTGACAGTAGGTCTGATTATCTTTAGCATTATTACTGTTGTTCAATTTATCG
TCATCACAAAGGGCTCAGAACGGGTTGCTGAAGTGAGCGCCCGCTTTTCTTTGGATGGAATGCCCGGTAAACAAATGAGT
ATTGATGGTGATTTACGATCAGGATCTATCGATTCGGCTGAAGCGGGGAGACAAAGAGAACGAGTTCAAAAAGAAAGTCG
CTTGTTTGGTGCGATGGATGGTGCGATGAAATTCGTTAAAGGAGACGCAATTGCAAGTATCATCGTGATTTTGGTCAATA
TTATTGGTGGCATTTCGGTTGGGGTTTTTCAACACCAGATGTCTGCGAGCGAGGCATTACAAACTTATGCGGTTCTCTCT
GTCGGGGATGGTTTGGCCTCTCAAATCCCTTCCCTCCTGATTTCAATCACTGCCGGGATTGTGGTAACACGAGTACCAGG
GAAAGAAAGAAAAAGTCTTGCAAATGAATTAGCTAATCAAGTGGGCAGGCAACCTGAAGCTTTATGGATGGCCGGAGGTA
TTTTGCTCGTATTTGCATTGATCCCAGGTTTTCCTTTTTTCGTTTTTGCTTTGTTGGCTTCTCTTGTTGCCAGCCCCGCT
TTTCTTGTTTATCGCAAAAAAAAGAAGCTCGGCCAATCTGAATCTATGGGTTTGAATGCCGACGGGGAACCTCAAAATGA
AATGAAGCCAGGGGCTGTGCCTTTACTGCTACATTGTGCGCCCAATTTAAACCGCTCTAATCTCAAAACGGAAATTGATT
CACTGCGTTTACGTCTTTTTGAACACCTTGGCCTACCAGTCCCTGAGGTCGTTGTACATATCAATCAACAATTAGAAAAA
AATGGTTTATCCATCAGCGTCTATCAGGAAAGAGTATTAGAATTGGTATTAGCAGAAAATGAATTGCTGATCGAACGGCC
TCACGCCGAATTAACAGTACGCCATCAAAATTTAAGCCGACGTATGGGCGAGCTGTATTGGATATCTTCTGACCAAAAAT
CACAGGCAATAAGCTTGAAGATCACTTTTTTTGAAGGGGACGAACGCATTATTCAATGCTTGAATTATGTGTTTGAGCGC
CATTCTTCTGAATTTATCGGTGTACAGGAAACTCGTTATTTAATGGATGCTATGGAAAAAAATTATGCGGAACTGATAAA
AGAGTTGCAGCGTCAAATGCCGGTGAACAAAATTTCAAATATTTTGCAAAAACTGGTACAGGAAAACATTTCTATCCGCG
ATCTGCGAACCATTTTTGGCGCAATAGTGGAATGGGCACCTAAAGAAAAAGACAATGTGATGTTGACCGAATATGTCCGT
ATTGCGCTTAGGCGTCATATCTGCCAACGTTTTAGCCACAGTAAAAATTATTTGACCGTATTTCGTGTAGGGGAAGGGCT
AGAAAATATTATTCGTCGTTCTATTCGTCAGACTTCTGCAGGCGCTTATTCAGAGCTCAATGCAAAAAAATCCACTCTCA
TTTTAAATAAAATTAAAAAATCCATTGAAAATAAAACGGATATTTTATTACTAACCAGCATCGATGTACGCCACTACTTG
CGTAAAATGATTGAACATGATCTCTTTTCATTACCTGTCTTATCTTTTCAGGAAATAGGCGATGAAATGCCGATTAAAGT
AGAAGGCATGGTCGAATTCATTGGAGAAGAGTTAAATGAGTTTGAATAA

Protein sequence : 
MVMRGDKIKKALALLLERQDIFLAVMLLVAIFMMILPLPTELIDVLIAVNLGLSAILLMISIYIRDPLEFSVFPSLLLIT
TLYRLALTISTSRLVLLQHDAGEIVEAFGQFVVGGNLTVGLIIFSIITVVQFIVITKGSERVAEVSARFSLDGMPGKQMS
IDGDLRSGSIDSAEAGRQRERVQKESRLFGAMDGAMKFVKGDAIASIIVILVNIIGGISVGVFQHQMSASEALQTYAVLS
VGDGLASQIPSLLISITAGIVVTRVPGKERKSLANELANQVGRQPEALWMAGGILLVFALIPGFPFFVFALLASLVASPA
FLVYRKKKKLGQSESMGLNADGEPQNEMKPGAVPLLLHCAPNLNRSNLKTEIDSLRLRLFEHLGLPVPEVVVHINQQLEK
NGLSISVYQERVLELVLAENELLIERPHAELTVRHQNLSRRMGELYWISSDQKSQAISLKITFFEGDERIIQCLNYVFER
HSSEFIGVQETRYLMDAMEKNYAELIKELQRQMPVNKISNILQKLVQENISIRDLRTIFGAIVEWAPKEKDNVMLTEYVR
IALRRHICQRFSHSKNYLTVFRVGEGLENIIRRSIRQTSAGAYSELNAKKSTLILNKIKKSIENKTDILLLTSIDVRHYL
RKMIEHDLFSLPVLSFQEIGDEMPIKVEGMVEFIGEELNEFE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
YPO0266 YP_002345347.1 secretion system apparatus protein SsaV Virulence Not named Protein 0.0 69
ssaV NP_460379.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 2e-161 55
ssaV CAA70536.1 secretion system apparatus Virulence SPI-2 Protein 1e-161 55
ssaV YP_216422.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 2e-161 55
ssaV NP_456114.1 putative type III secretion protein Virulence SPI-2 Protein 4e-161 55
ssaV NP_805085.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 4e-161 55
escV AFO66414.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 2e-126 49
escV AFO66296.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-126 49
escV YP_003236089.1 putative translocator EscV Virulence LEE Protein 1e-128 48
escV CAC81861.1 EscV protein Virulence LEE II Protein 7e-129 48
escV NP_290269.1 hypothetical protein Virulence LEE Protein 9e-129 48
escV AAC31514.1 L0035 Virulence LEE Protein 6e-129 48
ECs4569 NP_312596.1 hypothetical protein Virulence LEE Protein 9e-129 48
escV ACU09459.1 EscV protein Virulence LEE Protein 6e-129 48
escV YP_003232152.1 T3SS structure protein EscV Virulence LEE Protein 7e-129 48
escV AAK26714.1 EscV Virulence LEE Protein 5e-129 48
escV YP_003223476.1 translocator EscV Virulence LEE Protein 5e-129 48
escV AAL57541.1 EscV Virulence LEE Protein 5e-129 48
escV CAI43875.1 EscV protein Virulence LEE Protein 4e-129 48
escV AAC38382.1 EscV Virulence LEE Protein 2e-129 48
unnamed AAL06368.1 EscV Virulence LEE Protein 4e-128 48
lssD AAO18050.1 LssD Virulence TTSS locus Protein 1e-125 45
ysaV AAS66840.1 YsaV Not tested SSR-1 Protein 5e-102 41
invA AAS66860.1 InvA Not tested SSR-2 Protein 9e-95 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG0514 Protein 8e-162 55
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG0813 Protein 4e-129 48
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG0729 Protein 1e-129 48
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG0064 Protein 2e-132 45
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG0198 Protein 1e-107 45
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG0384 Protein 2e-126 45
ssaV YP_002923050.1 secretion system apparatus protein SsaV VFG2126 Protein 1e-102 41