Gene Information

Name : murD (KP1_0910)
Accession : YP_002917802.1
Strain : Klebsiella pneumoniae NTUH-K2044
Genome accession: NC_012731
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : -
Position : 894214 - 895530 bp
Length : 1317 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGGCAGATTATCAGGGTAAAAAAGTCGTCATTATTGGGCTGGGCATGACCGGCCTGTCATGCGTGGACTTTTTCATGGC
GCGCGGCGTAACCCCGCGCGTGATGGACACCCGCGTCGCGCCTCCGGGGCTGGATAAATTACCCGAATCGGTCGAATGCC
ATGTCGGCGGACTCAATGATACCTGGCTGCTGGCGGCGGACCTGATTGTCGCCAGTCCGGGGATTGCGCTGGCCCATCCT
TCGCTCAGCGCAGCGGCCGACGCTGGCGTAGAGATCGTTGGCGATATCGAACTGTTCTGCCGCGAAGCGCAGGCGCCGAT
TATCGCCATTACCGGTTCTAACGGCAAAAGCACTGTTACTACCCTGGTGGGCGAGATGGCGAAAGCCGCTGGAGTTAACG
TCGGCGTGGGCGGCAATATCGGCCTGCCGGCGCTGATGCTGCTGGACACCGATCGAGAGCTGTATGTGTTGGAGCTCTCC
AGCTTCCAGCTGGAAACCACCTTCAGCCTGCAGGCGGTGGCGGCAACCATCCTCAACGTGACTGAGGACCATATGGACCG
CTACCCGCTGGGGCTGCAGCAGTATCGCGCGGCGAAGCTGCGGATTTACGAGAATGCGAAGACCTGCGTGGTGAATGCGG
ACGATGCGCTCACCATGCCGGTACGCGGGGCGGACGAACGCTGCATTAGCTTTGGCGTCGATGTCGGTGACTACCACCTT
AACCGCCAGCAGGGCGAAACCTGGCTGCGCGTTAAAGGTGAGAAAGTCCTCAATGTGAAAGAGATGCCTCTCACCGGTCA
GCATAACTACAGCAACGCCCTGGCGGCGCTGGCGCTGGCCGATGCCGCAGGTCTGCCGCGGGCCAGCAGCCTGAAGGCGC
TGACCACCTTTACCGGTCTGGCGCACCGTTTCCAGTTGGTGCAGGAACACAACGGCGTACGCTGGATTAACGACTCGAAG
GCGACCAACGTCGGCAGCACTGAGGCGGCGCTGAACGGCCTGCAGCTGGACGGCACGCTCTATCTGCTGCTGGGCGGCGA
CGGCAAGTCCGCTGATTTCACCCCGCTGAAGCGCTACCTCGGCGGCGATCGTATTCGCCTGTACTGCTTTGGTCGCGATG
GCGCCGAGCTCGCTGAGCTGCGTCCTGAGGTGGCGGTACAAACTGAGACTATGGAACAGGCGATGCGTCAGATTGCTCCC
CTGGTGAAAGCGGGGGACATGGTGCTCCTGTCGCCGGCCTGCGCCAGCCTGGATCAGTTTAAGAACTTTGAACAACGGGG
CGAGATGTTTGCCCGTCTGGCGAAGGAGTTAGGTTGA

Protein sequence :
MADYQGKKVVIIGLGMTGLSCVDFFMARGVTPRVMDTRVAPPGLDKLPESVECHVGGLNDTWLLAADLIVASPGIALAHP
SLSAAADAGVEIVGDIELFCREAQAPIIAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDTDRELYVLELS
SFQLETTFSLQAVAATILNVTEDHMDRYPLGLQQYRAAKLRIYENAKTCVVNADDALTMPVRGADERCISFGVDVGDYHL
NRQQGETWLRVKGEKVLNVKEMPLTGQHNYSNALAALALADAAGLPRASSLKALTTFTGLAHRFQLVQEHNGVRWINDSK
ATNVGSTEAALNGLQLDGTLYLLLGGDGKSADFTPLKRYLGGDRIRLYCFGRDGAELAELRPEVAVQTETMEQAMRQIAP
LVKAGDMVLLSPACASLDQFKNFEQRGEMFARLAKELG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 2e-51 43
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 2e-51 43