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Name : ureC (KP1_4757) Accession : YP_002921306.1 Strain : Klebsiella pneumoniae NTUH-K2044 Genome accession: NC_012731 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 4540828 - 4542531 bp Length : 1704 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGTAATATTTCACGCCAGGCCTATGCCGATATGTTCGGCCCCACCGTCGGCGACAAGGTGCGCCTGGCGGATACCGA GCTGTGGATCGAGGTGGAGGACGATTTGACCACCTACGGGGAAGAGGTCAAATTCGGCGGCGGCAAAGTGATCCGCGACG GCATGGGCCAGGGACAGATGCTGGCCGCCGACTGTGTCGACCTGGTGCTCACCAACGCGTTGATCGTCGATCACTGGGGG ATCGTTAAGGCCGATATCGGCGTGAAGGACGGCCGGATCTTCGCCATCGGCAAAGCCGGCAACCCCGACATCCAGCCCAA CGTCACCATCCCCATCGGCGCCGCGACGGAAGTGATTGCCGCCGAAGGAAAAATTGTCACCGCCGGCGGGATCGATACCC ATATTCACTGGATCTGTCCGCAGCAGGCGGAAGAGGCGCTGGTCTCCGGCGTGACCACCATGGTCGGCGGCGGCACCGGC CCGGCCGCGGGCACCCATGCCACCACCTGCACCCCGGGCCCGTGGTATATCTCACGCATGCTGCAGGCGGCCGACAGCCT GCCGGTCAATATCGGCCTGCTGGGCAAGGGCAACGTTTCTCAGCCGGATGCCCTGCGCGAGCAGGTGGCGGCGGGCGTTA TTGGCCTGAAGATCCATGAGGACTGGGGCGCCACCCCGGCGGCGATCGACTGTGCGTTAACCGTCGCCGATGAAATGGAC GTCCAGGTCGCCCTGCACAGCGACACCCTGAATGAATCCGGTTTTGTGGAAGACACCCTCGCCGCCATCGGCGGACGCAC CATCCACACCTTCCATACCGAAGGGGCCGGCGGCGGCCATGCGCCGGACATCATCACCGCCTGCGCCCACCCGAACATTT TGCCGTCGTCCACCAACCCAACGCTGCCCTACACCCTCAACACCATCGATGAACATCTCGATATGCTGATGGTCTGCCAC CATCTGGACCCGGACATCGCCGAGGACGTGGCCTTTGCCGAGTCGCGCATTCGCCGGGAAACCATCGCTGCGGAAGACGT GCTGCACGATCTCGGCGCCTTCTCGCTCACCTCCTCCGATTCGCAGGCCATGGGCCGCGTCGGGGAAGTGATTCTCCGCA CCTGGCAGGTGGCGCATCGCATGAAGATGCAGCGCGGAGCGCTGGCGGAGGAGACCGGGGATAACGACAACTTCCGCGTG AAGCGCTACATCGCCAAATACACCATCAACCCGGCGCTGACCCACGGCATCGCACACGAAGTCGGATCCATTGAGGTGGG TAAGCTGGCTGACCTCGTGGTCTGGTCACCAGCCTTCTTCGGCGTGAAACCGGCCTCCGTGATCAAAGGCGGCATGATCG CCATCGCGCCGATGGGCGATATCAATGCCTCTATTCCGACCCCGCAGCCGGTGCACTACCGCCCGATGTTTGGCGCGCTG GGCAGCGCCCGCCATCACTGCCGCCTCACCTTCCTGTCGCAGGCGGCGGCAGCCAATGGCGTTGCCGAGCGGCTGAACCT GCGCAGCGCGATCGCCGTGGTGAAAGGCTGCCGTACGGTGCAGAAAGCCGACATGGTGCACAACAGCCTGCAGCCTAACA TCACCGTCGACGCCCAGACCTATGAGGTGCGGGTGGATGGCGAACTTATCACCAGCGAGCCGGCAGACGTTCTGCCGATG GCGCAACGATATTTTCTGTTTTAA Protein sequence : MSNISRQAYADMFGPTVGDKVRLADTELWIEVEDDLTTYGEEVKFGGGKVIRDGMGQGQMLAADCVDLVLTNALIVDHWG IVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVTAGGIDTHIHWICPQQAEEALVSGVTTMVGGGTG PAAGTHATTCTPGPWYISRMLQAADSLPVNIGLLGKGNVSQPDALREQVAAGVIGLKIHEDWGATPAAIDCALTVADEMD VQVALHSDTLNESGFVEDTLAAIGGRTIHTFHTEGAGGGHAPDIITACAHPNILPSSTNPTLPYTLNTIDEHLDMLMVCH HLDPDIAEDVAFAESRIRRETIAAEDVLHDLGAFSLTSSDSQAMGRVGEVILRTWQVAHRMKMQRGALAEETGDNDNFRV KRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSPAFFGVKPASVIKGGMIAIAPMGDINASIPTPQPVHYRPMFGAL GSARHHCRLTFLSQAAAANGVAERLNLRSAIAVVKGCRTVQKADMVHNSLQPNITVDAQTYEVRVDGELITSEPADVLPM AQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 91 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 91 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-166 | 64 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-166 | 64 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-166 | 64 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-166 | 64 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002921306.1 | urease subunit alpha | VFG0270 | Protein | 6e-154 | 63 |
