Gene Information

Name : thyA (KP1_4505)
Accession : YP_002921078.1
Strain : Klebsiella pneumoniae NTUH-K2044
Genome accession: NC_012731
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : -
Position : 4322863 - 4323657 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAGTATCTTGATTTGATGCAGAAAGTGCTCACCGAGGGCACGCCAAAAAATGACCGCACCGGCACTGGCACGAT
CTCTATTTTCGGCCATCAGATGCGTTTTAACCTGCAGGAAGGCTTCCCGCTGGTGACCACCAAGCGCTGTCATTTACGCT
CCATCATCCATGAACTGCTGTGGTTCCTGCAGGGCGACACCAACATCGCCTATCTGCATGAGAACAACGTCACCATCTGG
GACGAGTGGGCGGATGAGAATGGCGACCTGGGGCCGGTCTACGGCAAACAGTGGCGTTCCTGGCCTGCGCCGGACGGCCG
CCATATCGACCAGATCAGCACGGTAATGAACCAGCTGAAAAACGACCCGGACTCCCGCCGGATCATCGTCTCGGCATGGA
ACGTCGGCGAGCTGGATAAAATGGCGCTGGCGCCGTGCCACGCCTTCTTCCAGTTCTACGTCGCCGACGGCAAGCTCTCC
TGCCAGCTGTATCAGCGTTCCTGCGATGTGTTCCTCGGCCTGCCGTTCAATATCGCCAGCTACGCGCTGCTGGTGCATAT
GGTGGCGCAGCAGTGCGATCTGCAGGTCGGTGATTTCGTCTGGACCGGCGGAGACACCCATCTGTACAGCAACCATCTTG
AGCAGACCAACCTGCAGCTAAGCCGCGAACCGCGTCCGCTGCCGAAGCTGGTCATCAAACGCAAGCCGGCGTCGATCTTC
GACTACCGCTTTGAAGACTTCGAGATTGAAGGTTACGATCCGCACCCGGGTATTAAAGCGCCGGTGGCGATTTAA

Protein sequence :
MKQYLDLMQKVLTEGTPKNDRTGTGTISIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIW
DEWADENGDLGPVYGKQWRSWPAPDGRHIDQISTVMNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS
CQLYQRSCDVFLGLPFNIASYALLVHMVAQQCDLQVGDFVWTGGDTHLYSNHLEQTNLQLSREPRPLPKLVIKRKPASIF
DYRFEDFEIEGYDPHPGIKAPVAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-88 67