Gene Information

Name : thiC (KP1_0234)
Accession : YP_002917203.1
Strain : Klebsiella pneumoniae NTUH-K2044
Genome accession: NC_012731
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 243477 - 245372 bp
Length : 1896 bp
Strand : -
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGTCTACTACCAAACTAACCCGTCGGGAACAACGCGAGCACGCGCAGCGATTCATTGATACGCTGGCGGGTACCGCTTT
TCCTAATTCACGCCGCATCTATGTTCACGGCTCACAAGCGGATATCCGCGTCCCGATGCGTGAAATTCAGCTCAGCCCAA
CTCTCGTCGGCGGCGATAAAGATAACCCCCGGTACGAAACCAACGAACCGATCCCGGTGTATGACACCTCCGGGCCGTAT
GGCGACCCGGATATTAGCATTGATGTCCGCCAGGGGCTGGCAAAGCTGCGCCAGCCGTGGATCGACGCGCGTAACGACTG
CGCGCCACTCAGCGAACGCAGCTCGGCCTATACCAAAGCGCGGCTGGCCGACGACGGTCTCGATGAGCTGCGCTTCAGCG
GCCTGCTGACGCCCAAACGCGCCGTCGTTGGCAAATGCGTTACCCAGCTGCACTACGCCCGCCAGGGGATAGTCACCCCG
GAGATGGAGTTCATCGCCATTCGCGAAAACATGGGTCGCGAACGTATCCGCAGCGAGGTTCTGCGCCAGCAGCACGCAGG
TGAAGGCTTCGGCGCCCACCTACCGGAAAACATCACCCCCGAGTTTGTTCGCGATGAAGTGGCCGCCGGACGCGCCATCA
TCCCCGCCAACATCAACCACCCGGAGTCTGAACCGATGATTATCGGCCGCAACTTCCTGGTGAAAGTGAATGCCAATATC
GGCAACTCGGCGGTGACCTCTTCCATCGAAGAAGAGGTCGAGAAACTGGTCTGGTCAACCCGCTGGGGCGCCGACACGGT
GATGGACCTCTCCACCGGCCGCTATATCCACGAAACCCGCGAGTGGATCCTGCGCAACAGCCCGGTGCCGATTGGTACCG
TGCCGATTTACCAGGCGCTGGAGAAGGTCAACGGCATCGCCGAGAATCTCACCTGGCAAGTCTTCCGCGATACCCTGCTG
GAACAGGCCGAGCAAGGCGTCGACTACTTCACGATTCACGCCGGCGTACTGTTGCGCTACGTCCCGATGACGGCGAAGCG
CCTGACCGGTATCGTCTCGCGCGGCGGCTCAATCATGGCTAAGTGGTGCCTGTCGCATCATCAGGAAAACTTCCTCTACC
AGCATTTCCGCGAAATCTGCGAAATCTGCGCCGCCTATGACGTGTCGCTGTCGCTGGGCGATGGCCTGCGCCCCGGCTCC
ATTCAGGATGCCAACGACGAGGCGCAGTTTTCCGAGCTGCGCACCCTCGGCGAACTGACGAAAATCGCCTGGGAATATGA
CGTGCAGGTGATGATTGAAGGCCCTGGCCACGTGCCGATGCAGATGATCCGCCGCAATATGACCGAACAGCTGGAGCACT
GCCACGAAGCGCCGTTCTACACCCTGGGGCCGCTCACCACTGATATCGCGCCGGGCTACGACCATTTCACCTCCGGTATC
GGCGCGGCAATGATCGGCTGGTTCGGCTGCGCCATGCTGTGCTATGTCACGCCGAAAGAGCATCTCGGCCTGCCCAACAA
AGAGGATGTCAAACAGGGGCTGATTACCTACAAAATCGCCGCCCACGCCGCCGACCTCGCGAAAGGCCACCCCGGGGCGC
AGATCCGCGACAACGCGATGTCAAAAGCGCGTTTTGAATTCCGCTGGGAAGACCAGTTCAACCTCGCGCTCGACCCGTTC
ACCGCGCGGGCCTATCACGATGAAACCCTGCCGCAGGAGTCCGGCAAAGTCGCCCACTTCTGCTCCATGTGCGGGCCGAA
ATTCTGTTCGATGAAAATCACTCAGGAGGTCCGCGACTACGCCGCGAAGCAAAGTATCGAAGCCGGCATGGCCGATATGT
CGAATAACTTCCGCGCCCGCGGCGGCGAAATCTACCTGAAACAGGAGGAAGCCTGA

Protein sequence :
MSTTKLTRREQREHAQRFIDTLAGTAFPNSRRIYVHGSQADIRVPMREIQLSPTLVGGDKDNPRYETNEPIPVYDTSGPY
GDPDISIDVRQGLAKLRQPWIDARNDCAPLSERSSAYTKARLADDGLDELRFSGLLTPKRAVVGKCVTQLHYARQGIVTP
EMEFIAIRENMGRERIRSEVLRQQHAGEGFGAHLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAENLTWQVFRDTLL
EQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHQENFLYQHFREICEICAAYDVSLSLGDGLRPGS
IQDANDEAQFSELRTLGELTKIAWEYDVQVMIEGPGHVPMQMIRRNMTEQLEHCHEAPFYTLGPLTTDIAPGYDHFTSGI
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPF
TARAYHDETLPQESGKVAHFCSMCGPKFCSMKITQEVRDYAAKQSIEAGMADMSNNFRARGGEIYLKQEEA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 72
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 72
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 0.0 70