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Name : ureC (ckrop_0806) Accession : YP_002906105.1 Strain : Corynebacterium kroppenstedtii DSM 44385 Genome accession: NC_012704 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 949981 - 952173 bp Length : 2193 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGCACTGCAAATAGATATATCTACGACGACGGAACAATCACTATTAACCCGGGTAGAAGGACACTCACGCTACGAGT CACCAATACCGGGGACCGAGCCGTACAAGTGGGAAGCCATTTCCATTTCTTCGAAGCCAATCGCGAATTACTCTTCGATC GTCATCGGGCATGGGGTATGCACCTCAATATTCCAGCGGGATTAGCTGTCCGATTCGAACCCGGCGATTCGAAAGAAGTT CAATTAGTTGATTTCGGTGGGCGCAGAATCCTGCATGGCTTTAGTGCTTTGGTGGAAGGTGCTCTCGACGATCCTGCCAT TCGCGAGCGGGGTCTCCAACGAGCACAGGAACGCGGTTTTAAAACAGAATCTGTACCTGACGACCAATTGCCCGCCGACC GGGGGCCGTACTCTATTTCCAAAGCGGAATATGGTTCCATTTATGGCCCAACGACGGGCGACCGCATTCAGCTTGCCGAC ACCAACCTCGTTATCGAATTAACTGATGATGCTAATTCGCGATCGTATGGGGACGAATCGGTGTATGGCGGTGGCAAAGC CATTCGTGATGGGATGGCACAGGACCCTCAAGCTTCCGATGCGGAATCCGTCGACACTGTTATTACGAGCGCGCTCATCG TTGATGCAATGACGGGGATTATCAAGGCCGATATCGGGATTAAAGATGGGCGAATTGTTGGAATTGGCAAGGCGGGTAAC CCGCATACCCAGGATGGTGTTGACCCGCAGCTGATCATTGGGCCCAATACTGAAGTTATCGCAGGCGAACATCGAATTGT GACTGCCGGCGGGATTGATTCGCATATCCATTTTATTTCTCCTCAGCAAGCCGAAGAGGGATTATCAAACGGAATTACGA CGTTTTTCGGCGGCGGAACCGGTCCTGCCGAAGGAACAAAAGGGACTACCTGCACGCCGGGAGAAAGCTCCATCGGTATG ATGCTGCGAGCTGCCGAAGATATGCCGGTCAATATCGGAGTGCTTGGCAAAGGATCGGGCTCGCTTCCCGAAGCTTTAGA GTCGCAAATTGCAGCTGGGGCCGCAGGATTAAAAATTCACGAAGACTGGGGAGCAACACCAGCCGTGGTTGATAACGCTC TCAAGGTCTGCGACAAACATGATGTTCAGCTTGCCATCCATACTGACACGCTAAACGAAAGCGGGTTCTTCGAGGACACG CGCGATGCCATCGGGGACCGAACGATTCACACCTTCCACTCCGAAGGCGCTGGTGGGGGCCATGCACCCGATATCCTCCG TGTGACGGGGATGCCTTCGGTGCTCCCCGCGTCAACGAACCCTACTCTCCCTTACACAGTCAATAGTGCCGAAGAGCTCC TCGACATGGTGATGGTTTGTCACCATCTGTCTCATGACATTCCGGAGGACGTATCTTTCGCGGAATCCCGCGTCAGACCC GAAACTATCGCTGCTGAAACGATTCTCCACGATAGAGGGGTCATTTCAATTTTCAGTTCAGATTCGCAAGCGATGGGACG TGTTGGGGAGACCTGGACCCGTGCTTTCCAAACTGCACACCATTGCAAAGCAGAACTCGGTCCTCTCCCCGAGGATCGCC AACCAGGCCCTGGGCAATCCGCATCCGTTGAGTCAACAGGCTCCGAGGCCGACGCACAGTCCACATCACGGAACGACAAC CATCGCGTCCTCCGTTACGTCGCTAAAGTGACGTGCAATCCCGCAATCGCCGCCGGAGTCAACGACTACATCGGGTCATT GGAAGTCGGAAAAGTCGCGGACATTGTCCTGTGGCCGGTGTCGTCGGTTGCTGTAAAGCCACAGCTCGTGATCCGCAGCG GTCACATTTGTTGGTCCCTGATGGGCGACCCCAATGCTTCTCTCCCCACTCCGGAGCCAGTCGTGTACCGACCCATGTTT GGCAATCGCGGTCACGCGCTTCCCCACAGCCGGATCACGTTCATGTCTTCCGAAGCTATTAACGACGGTGTGCCCGGAAA ACTGAGCCTCACCAGCACCGTTTTGCCCGTTCACGGTTGTCGACACATCGGAAAGAAAGACATGGTGAGGAACTGTGAGC TACCAGAAATCACCGTGGACCCCGATACTTACGAGGTTCGAGCGGACGGTGAACCGCTCACCATCGCGCCCGCTGACAAG CTTCCCTTAGCTCAACTGCACTACTTGTTCTAA Protein sequence : MSTANRYIYDDGTITINPGRRTLTLRVTNTGDRAVQVGSHFHFFEANRELLFDRHRAWGMHLNIPAGLAVRFEPGDSKEV QLVDFGGRRILHGFSALVEGALDDPAIRERGLQRAQERGFKTESVPDDQLPADRGPYSISKAEYGSIYGPTTGDRIQLAD TNLVIELTDDANSRSYGDESVYGGGKAIRDGMAQDPQASDAESVDTVITSALIVDAMTGIIKADIGIKDGRIVGIGKAGN PHTQDGVDPQLIIGPNTEVIAGEHRIVTAGGIDSHIHFISPQQAEEGLSNGITTFFGGGTGPAEGTKGTTCTPGESSIGM MLRAAEDMPVNIGVLGKGSGSLPEALESQIAAGAAGLKIHEDWGATPAVVDNALKVCDKHDVQLAIHTDTLNESGFFEDT RDAIGDRTIHTFHSEGAGGGHAPDILRVTGMPSVLPASTNPTLPYTVNSAEELLDMVMVCHHLSHDIPEDVSFAESRVRP ETIAAETILHDRGVISIFSSDSQAMGRVGETWTRAFQTAHHCKAELGPLPEDRQPGPGQSASVESTGSEADAQSTSRNDN HRVLRYVAKVTCNPAIAAGVNDYIGSLEVGKVADIVLWPVSSVAVKPQLVIRSGHICWSLMGDPNASLPTPEPVVYRPMF GNRGHALPHSRITFMSSEAINDGVPGKLSLTSTVLPVHGCRHIGKKDMVRNCELPEITVDPDTYEVRADGEPLTIAPADK LPLAQLHYLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 4e-128 | 56 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 4e-128 | 56 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-126 | 54 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-127 | 54 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-127 | 54 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-127 | 54 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002906105.1 | urease subunit alpha | VFG0270 | Protein | 8e-127 | 55 |
