Gene Information

Name : kdsB (GBP346_A0851)
Accession : YP_002895575.1
Strain : Burkholderia pseudomallei MSHR346
Genome accession: NC_012695
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 811675 - 812466 bp
Length : 792 bp
Strand : -
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGACCTCCCCGCTCCCTTTCGTCGCCGTCGTCCCCGCCCGCCTCGCGTCGACCCGCCTGCCGAACAAGCCGCTCGCCGA
TCTCGGCGGCAAGCCGATGGTCGTGCGCGTCGCCGAGCGCGCGCGTGAAGCCGGCGCGCAGCAGGTGCTCGTCGCATCCG
ACGCGCAGCGCGTGCTCGACGCGGTGCGCGAGCACGGCTTCGACGCGGTGCTCACGCGCGCCGACCATCCGTCCGGCACC
GATCGCCTCGCCGAGGTCGCCGCGAAGCTCGGCTTCGACGACGACACGATCGTCGTCAACGTCCAGGGCGACGAGCCGCT
GATCGATCCGCAGCTCGTGCGCGACGTAGCGTCGCACCTCGCCGCGCACCCGTCGTGCGCGATCGCGACGGCCGCGCACC
CGATTCACGAAGCGCACGAGGTGTTCAATCCGAACTACGTGAAGGTCGTGCTCGACGCGCACGGCGTCGCGCTGTACTTC
TCGCGCGCGCCGATTCCGTGGTCGCGCGATGCTTACCTGCCGCACTGGCCGAACGTCGCGGCGATGCCCGCGCCGACGTG
CCCGGTCTATCGGCACATCGGCCTGTACGCGTATCGCGCGCGCTTCCTGCGCACGTATCCGACGCTCGCGCAGGCGCCGA
TCGAGGCGGCCGAACAGCTCGAGCAGTTGCGCGCGATGTGGCATGGCGAGCGGATCGCGGTGCGCGTCACCGAGCATGCG
CCCGAGGCCGGCATCGACACGCCGGCCGATCTCGAACGCGTGCAGGCCCTTTTTCGGTCTCGCGCCAAATAA

Protein sequence :
MTSPLPFVAVVPARLASTRLPNKPLADLGGKPMVVRVAERAREAGAQQVLVASDAQRVLDAVREHGFDAVLTRADHPSGT
DRLAEVAAKLGFDDDTIVVNVQGDEPLIDPQLVRDVASHLAAHPSCAIATAAHPIHEAHEVFNPNYVKVVLDAHGVALYF
SRAPIPWSRDAYLPHWPNVAAMPAPTCPVYRHIGLYAYRARFLRTYPTLAQAPIEAAEQLEQLRAMWHGERIAVRVTEHA
PEAGIDTPADLERVQALFRSRAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 1e-31 44
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 1e-32 44
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 2e-32 44