Gene Information

Name : GBP346_A4119 (GBP346_A4119)
Accession : YP_002898772.1
Strain : Burkholderia pseudomallei MSHR346
Genome accession: NC_012695
Putative virulence/resistance : Resistance
Product : heavy metal cation transport ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 3945646 - 3948138 bp
Length : 2493 bp
Strand : -
Note : identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01512; match to protein family HMM TIGR01525

DNA sequence :
ATGACCGAGGCCACCCGGGCCGAAAACCGGCCGCGAACGCCAGAAGCCGATCGCGGCGGCGCGCAGTCGGGCGATGCGCG
CACATCGGCGCGCGCCGCTGGCTGCTGCTCGCACCATCACCCGCATGGCGAGGTCGAAACGCAGGCGAATCTCGCGGTTC
AGTCAAGCAATCGCGATTCGAGCGACCACGCACATGCACCCCATTCGCATGCGAACGGCGACCATCCGCACGACCACGAC
CACGACCACGACCACGACCGCGACCGCGACCACGACGGCGCGGCGTGCTGCGCGCCCGCCCCCGTCGCGTTCGCGCCGTT
GCCCGGCGCGCGAAAGGCCGCCGGCGGCCGTGTGCGCTCGGCGTTCCGGATCATGCAGATGGACTGCCCGACCGAGGAGA
CACTGATCCGCAAGAAGCTGGGCGCGATGTCCGAAGTCGCGGCGCTCGAATTCAACCTGATGCAGCGGATGCTCGCGGTC
GAGCACGTGCCGGGCGCGGAAGCCGGCATCGCCGCCGCGATCCGCTCGCTCGGCATGACGCCCGAACAGGCGGACGCCGG
CGCGTCGGGCCGTGGCGCGTTGCCCGCGCCGGCCGACGCGCCGCGCCCGTGGTGGCCGCTCGCGGTCGCGGGCGTCGCGG
CGGCGGCGTCGGAAGCGGCCACGTGGCTGCAACTGCCGGTATGGCTCGCCGCCGCGCTCGCGCTCGCCGCGGTCGCGACC
TGCGGCCTCGGCACGTATCGCAAGGGCTGGATCGCGCTCACGAACGGCAACCTGAACATCAACGCGCTGATGAGCATCGC
GGTGACGGGCGCGATGGCGATTGGCCAGTGGCCCGAGGCCGCGATGGTGATGGTGCTCTTCACCGTCGCCGAATTGATCG
AGGCGCGCTCGCTCGACCGTGCGCGCAACGCGATCCAGAGCCTGATGCGCCTCGCGCCCGACACCGTGACGCTCAGGCAG
CCCGACGGCACGTGGCAGCCGGTCGACGCCGCGCAGGTCGCGCTCGGTGCGATCGTGCGCGTGAAGCCGGGCGAGCGCAT
CGGCCTCGACGGCGAGATCGTTGCCGGCCGCTCGACCGTCAACCAGGCGCCGATCACGGGCGAGAGCCTGCCCGTCGAGA
AAACCGAGGGCGACGCGGTGTACGCGGGCACGATCAACGAAGCCGGCTCGTTCGAATATCGGGTGACGGCGGTCGCGAGC
AACACGACGCTCGCGCGGATCATCCATGCGGTCGAGGAGGCGCAGGGCGCGAAGGCGCCGACGCAGCGCTTCGTCGACAG
CTTCGCGCGCGTCTACACGCCGATCGTGTTCGCGATCGCGCTCGTCGTCGCGATCGCGCCGCCGCTCGTGCTCGACGGCG
CATGGCGCGACTGGATCTATCGCGCGCTCGTGCTGCTCGTGATCGCGTGCCCATGCGCGCTCGTGATCTCGACGCCCGTG
ACGATCGTATCGGGGCTCGCGGCGGCCGCGCGGCGCGGGATTCTCGTGAAGGGCGGCGTGTACCTCGAGCAGGGGCGCCG
CCTCGCGTGGCTCGCGCTCGACAAGACGGGCACGATCACGCGCGGCAAGCCGGTGCAGACCGATTTCGAGATGCGCGCAG
CCGACGTCGACGCCGCGCTCGTGCGGGGGCTCGCCGCGCGCCTCGCCGCACGCTCGGATCACCCGGTTTCGCAGGCGGTC
GCGGCGGCGAGCGCGGCTCAAGCCGGCGCGGGCGGCGTCCCGCGCGCGAAGCCCGCGTCGTTCGCCGACGTCGCCGATTT
CGAGGCGATTCCCGGCCGCGGCGTGCGCGGCAAGATCGACGGCGTGCCGTACTGGCTCGGCAATCATCGCCTCGTCGAGG
AGCTCGACTGCTGCACGAGCGCGCTCGAAGCGCGTCTCGACGAGCTCGAGCGGCAGGGCAAGACGGTCGTGATGCTGATC
GACGGCGCGCGCGTGCTCGGCCTCTTCGCGGTGGCCGACACGGTGAAGGACACGAGCCGCGCGGCGGTTGCCGAGCTGCA
CGCGCTCGGCATCAAGACCGCGATGCTGACGGGCGACAACCCGCACACCGCGCAAGCGATCGCGCAGCAGGTCGGCATCG
ACGACGCGCGCGGCAACCAACTGCCGCAGGACAAGCTCGCCGCCGTCGAAGCGCTCGCGGCGGGCGGCCGCGCGGTCGGC
ATGGTCGGCGACGGGATCAACGACGCGCCGGCGCTCGCGCGCGCCGACATCGGCTTCGCGATGGGCGCGATGGGCACCGA
TACCGCGATCGAGACGGCCGACGTCGCGCTGATGGACGACGACCTGCGCAAGATCCCGGCGTTCGTGCGGCTGTCGCGCG
CGACGCATCGCGTGCTCGTGCAGAACATCGCGTTCGCGCTCGCCGTGAAGGCGGTGTTCGTCGGCCTCACGGTCGCGGGG
ATGGGCACGATGTGGATGGCGGTGTTCGCCGACGCGGGCGCGAGCCTCATCGTCGTCGGCAACGGCTTGCGGCTGTTGCG
CCGCGGCCAATGA

Protein sequence :
MTEATRAENRPRTPEADRGGAQSGDARTSARAAGCCSHHHPHGEVETQANLAVQSSNRDSSDHAHAPHSHANGDHPHDHD
HDHDHDRDRDHDGAACCAPAPVAFAPLPGARKAAGGRVRSAFRIMQMDCPTEETLIRKKLGAMSEVAALEFNLMQRMLAV
EHVPGAEAGIAAAIRSLGMTPEQADAGASGRGALPAPADAPRPWWPLAVAGVAAAASEAATWLQLPVWLAAALALAAVAT
CGLGTYRKGWIALTNGNLNINALMSIAVTGAMAIGQWPEAAMVMVLFTVAELIEARSLDRARNAIQSLMRLAPDTVTLRQ
PDGTWQPVDAAQVALGAIVRVKPGERIGLDGEIVAGRSTVNQAPITGESLPVEKTEGDAVYAGTINEAGSFEYRVTAVAS
NTTLARIIHAVEEAQGAKAPTQRFVDSFARVYTPIVFAIALVVAIAPPLVLDGAWRDWIYRALVLLVIACPCALVISTPV
TIVSGLAAAARRGILVKGGVYLEQGRRLAWLALDKTGTITRGKPVQTDFEMRAADVDAALVRGLAARLAARSDHPVSQAV
AAASAAQAGAGGVPRAKPASFADVADFEAIPGRGVRGKIDGVPYWLGNHRLVEELDCCTSALEARLDELERQGKTVVMLI
DGARVLGLFAVADTVKDTSRAAVAELHALGIKTAMLTGDNPHTAQAIAQQVGIDDARGNQLPQDKLAAVEALAAGGRAVG
MVGDGINDAPALARADIGFAMGAMGTDTAIETADVALMDDDLRKIPAFVRLSRATHRVLVQNIAFALAVKAVFVGLTVAG
MGTMWMAVFADAGASLIVVGNGLRLLRRGQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 4e-112 46
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 4e-112 46
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 3e-111 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GBP346_A4119 YP_002898772.1 heavy metal cation transport ATPase BAC0298 Protein 0.0 66