Gene Information

Name : hemC (GBP346_A1069)
Accession : YP_002895791.1
Strain : Burkholderia pseudomallei MSHR346
Genome accession: NC_012695
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 1036612 - 1037601 bp
Length : 990 bp
Strand : +
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence :
ATGAACTCCGAGACTCTTCCGGCCGAGCTGCCCGCGACGCTGACGATCGCGTCGCGCGAGAGCCGCCTCGCCATGTGGCA
AGCCGAGCATGTGCGTGATGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAAAATCCTCGGGATGACGACGCGCGGCG
ATCAAATTCTCGATCGCACGCTATCGAAGGTCGGCGGCAAGGGCCTGTTCGTCAAGGAGCTCGAGAGCGCGCTTGCCGAC
GGCCGCGCGGATCTCGCCGTGCATTCGCTGAAGGACGTGCCGATGGCGCTGCCCGAAGGCTTCGCGCTCGCGGCGGTGAT
GAGCCGCGAGGATCCGCGCGACGCGTTCGTGTCGAACGATTACGCGTCGCTCGACGCGCTGCCGGCGGGCGCCGTCGTCG
GCACGTCGAGCCTGCGCCGCGAGGCGATGCTGCGCGCGCGCCATCCGCGGCTCGACGTGCGGCCGCTGCGCGGCAATCTC
GACACGCGGCTCGCGAAGCTCGACCGCGGCGATTACGCGGCGATCATCCTCGCCGCCGCGGGCCTCAAGCGTCTCGGCCT
CGCCGCGCGGATCCGCGCGCTGCTCGACGTCGACGACAGCCTGCCCGCCGCGGGGCAGGGCGCGCTCGGCATCGAGATCG
CCGCGCGCCGCGCCGATGTCGCCGCGTGGCTCGCGCCGCTGCACGATCATGCGAGCGCGCTCGCGGTCGAGGCCGAACGC
GCGGTGTCGCGCGCGCTCGGCGGCAGTTGCGAGGTGCCGCTCGCCGCGCACGCGGTGTGGCGCGGCGGCGAGCTGCACCT
GACGGGCAGCGTGTCGACGACGGACGGCGCGCGCGTGCTCGCCGCGCATGCGCACGCACGCGCGGCGACGGCCGCCGATG
CGCTCGCGCTCGGCCGCAGGGTGTCCGACGCGCTCGAGCGGCAAGGCGCGCGCGCGATCGTCGACGCGCTCGTCGCGGCG
AGCGCGCAAGCGCAAAAGGGCGGCGCGTGA

Protein sequence :
MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALAD
GRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNL
DTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAER
AVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARAIVDALVAA
SAQAQKGGA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 2e-51 56
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 2e-51 56