Gene Information

Name : Tola_2769 (Tola_2769)
Accession : YP_002893948.1
Strain : Tolumonas auensis DSM 9187
Genome accession: NC_012691
Putative virulence/resistance : Virulence
Product : ATP-dependent chaperone ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 3041642 - 3044218 bp
Length : 2577 bp
Strand : -
Note : KEGG: aha:AHA_4071 ATP-dependent chaperone protein ClpB; TIGRFAM: ATP-dependent chaperone ClpB; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA

DNA sequence :
ATGCGCTTAGATCGTCTCACCAGCAAATTTCAGACTGCTATTTCTGATGCTCAGTCATTAGCACTCGGAAAAGATCATCA
GTTCATTGAACCCATTCACATCATGACAGCATTGCTGGATCAGCAAGGTGGATCTATTCGTCCACTACTGATCTTGGCCG
GATGTAATGTTGATACACTGCATCAGCGTCTTACGCAGGAATTAGATCGTTTGCCTCGTGTCAGTGGGGTTGACGGTGAT
ATTCAGATATCACCGCAACTGGGACGAATTCTGAATATGTGCGACAAGTTATCGCAGCAGCGGCAGGATCAATTCATTTC
TTCAGAAATGTTCTTGCTGGCCGCGCTGGATGATCGCGGTACTTTGGGTGATCTGCTACGCCAGAATGGTGTTGTGAAAG
ATAAACTGGATAAAGCGATCGAAAAAGTCCGTGGTGGTGAAAAGGTGACAGATGCCGGAGCGGAAGAAAAACGCCAGGCA
TTGGAAAAATATACAATTGATCTGACGGAACGAGCCGAGCAGGGCAAGCTTGATCCAGTCATTGGCCGTGATGAAGAGAT
CCGGCGTACCGTTCAGGTATTACAACGGCGTACTAAAAATAATCCAGTACTTATTGGCGAACCGGGTGTGGGTAAAACGG
CGATTGTAGAGGGACTGGCTCAACGCATTATTAATGGTGAAGTACCGGAAGGTTTGAAGCATAAACGGGTCTTGTCACTT
GATATGGGCTCGTTGCTGGCGGGGGCAAAATATCGCGGCGAATTTGAAGAACGTCTGAAAGCTGTACTGAATGAGCTGGC
TAAGCAGGAAGGCAATGTGATCCTGTTTATTGATGAGCTGCACACTATGGTGGGTGCTGGCAAGGCCGAAGGGGCGATGG
ATGCCGGTAACATGCTGAAGCCTGCACTGGCGCGTGGCGAGCTGCATTGTGTTGGCGCAACTACACTGGATGAATATCGT
CAATACGTTGAAAAAGATGCTGCCCTCGAACGTCGCTTCCAGAAAGTACTGGTGGATCAACCTTCGGTGGAAGATACGAT
CGCGATCCTGCGTGGCCTGAAAGAACGTTATGAACTGCATCATCATGTACAGATCACCGATCCGGCTATTGTTGCGGCAG
CGACATTATCACACCGTTATATTTCCGATCGGCAATTACCAGATAAAGCCATTGATCTGATTGATGAGGCGGCGGCCAGT
ATCCGTCTGCAAATAGATTCTAAACCGGAGCAACTGGATCGCCTCGAACGCCGTATCGTGCAGCTGAAAATGGAACAGCA
GGCCTTGATGAAAGAGTCTGACGTTGCCAGTGCCCAGCGATTAGGCATTATTAATAAAGAAATCACAGAAAAAGATCGTG
AATACAATGAGCTGGAAGAGATCTGGAAAGCTGAGAAAGCGGCACTGGCTGGTACACAGCATATCAAATCTGAATTAGAG
CAGGCTCGCCAGGAACTGGACGTCGCGCGTCGCGCCGGCGATCTTGCCAAAATGTCAGAGCTACACTATGGCCGTATCCC
TGAGTTGGAAAAACAACTGGACTTAGCTTCACAAGCAGAAATGCAGGAACAAACGTTATTACGTAACCGGGTAACCGATG
AGGAAATAGCAGAGGTTCTGTCTCGTTGGACTGGTATTCCGGTTGCTCGTATGCTGGAAGGCGAACGAGACAAACTGCTG
CGGATGGAAGAAAAGTTGCATCAGCGTGTTATCGGGCAGGATGAAGCCGTCAACGCGGTCGCAAATGCGATCCGCCGCAG
TCGCGCGGGCCTGTCTGATCCAATGAGACCAATTGGTTCATTCTTATTTCTGGGACCCACTGGTGTCGGGAAAACAGAAC
TGTGTAAAGCATTGGCGGAATTCCTGTTTGATACACAGGATGCCATGGTGCGTATTGATATGTCCGAATTCATGGAGAAA
CACTCCGTGGCCCGGTTAGTTGGTGCACCTCCCGGATACGTTGGTTACGAGGAAGGGGGATATCTGACAGAAGCGGTGCG
ACGTAAACCTTATTCGGTGATTTTGCTGGATGAGGTTGAAAAGGCGCATCCGGATGTATTCAACATCCTGTTACAGGTAT
TGGATGATGGCCGTCTGACCGATGGTCAGGGGCGTACGGTCGATTTCCGTAATGCGGTGATCATTATGACGTCCAATTTA
GGGTCGGATCTTATTCAGGAACACCACCACCTGATGGAATATCAGGAAATGAAATCCATGCTGATGGAAGTGTTAACGCG
GAGTTTCCGTCCTGAGTTCCTGAATCGAATAGATGAAACAGTCGTATTCCATCCATTGGGTGCGGAACATATTCAATCCA
TCGCCAAGATCCAGCTACAAAGCCTGGTGAAACGTCTCGAGGATATCGGCTATAAAGTAGAACTGCGTGATTCACTGCTC
AGTTATCTGGCTCAATCGGGCTTTGATCCTGTTTATGGTGCGCGTCCGCTAAAGCGTGCAATCCAGCAACAAGTGGAAAA
TCCACTGGCACAGGACATTCTTTCCGGAAAAGTATTACCTGGGAAAACACTGATATTGGATATCCGGGATGACAAATTGG
TAATTGAACAGGACTAA

Protein sequence :
MRLDRLTSKFQTAISDAQSLALGKDHQFIEPIHIMTALLDQQGGSIRPLLILAGCNVDTLHQRLTQELDRLPRVSGVDGD
IQISPQLGRILNMCDKLSQQRQDQFISSEMFLLAALDDRGTLGDLLRQNGVVKDKLDKAIEKVRGGEKVTDAGAEEKRQA
LEKYTIDLTERAEQGKLDPVIGRDEEIRRTVQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKHKRVLSL
DMGSLLAGAKYRGEFEERLKAVLNELAKQEGNVILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYR
QYVEKDAALERRFQKVLVDQPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAAAS
IRLQIDSKPEQLDRLERRIVQLKMEQQALMKESDVASAQRLGIINKEITEKDREYNELEEIWKAEKAALAGTQHIKSELE
QARQELDVARRAGDLAKMSELHYGRIPELEKQLDLASQAEMQEQTLLRNRVTDEEIAEVLSRWTGIPVARMLEGERDKLL
RMEEKLHQRVIGQDEAVNAVANAIRRSRAGLSDPMRPIGSFLFLGPTGVGKTELCKALAEFLFDTQDAMVRIDMSEFMEK
HSVARLVGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNAVIIMTSNL
GSDLIQEHHHLMEYQEMKSMLMEVLTRSFRPEFLNRIDETVVFHPLGAEHIQSIAKIQLQSLVKRLEDIGYKVELRDSLL
SYLAQSGFDPVYGARPLKRAIQQQVENPLAQDILSGKVLPGKTLILDIRDDKLVIEQD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 1e-159 51
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 6e-109 42
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 2e-105 41
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 2e-105 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tola_2769 YP_002893948.1 ATP-dependent chaperone ClpB VFG2076 Protein 2e-114 44
Tola_2769 YP_002893948.1 ATP-dependent chaperone ClpB VFG0079 Protein 2e-129 41