Gene Information

Name : guaA (Tola_2171)
Accession : YP_002893356.1
Strain : Tolumonas auensis DSM 9187
Genome accession: NC_012691
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 2377754 - 2379331 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGCAAAAATATTCATAAACATCGTATTCTGATCCTGGACTTCGGGTCGCAATATACTCAGCTGATTGCACGTCGTGT
GCGTGAAATTGGTGTGTATTGTGAACTGTGGGCGTGGGATGTTACTGAAGAGCAGATCCGTGAATTCAATCCGGATGGGA
TCATTCTGTCAGGCGGCCCGGAGTCAGTGACTGAATCTGACAGCCCGCGTGCTCCGGAATATGTATTTAATGCTGGTGTA
CCTGTGCTGGGCGTGTGCTATGGCATGCAGACCATGGCTGAACAGCTGGGTGGCAAAGTAGAAAGCTCTGACAAGCGTGA
ATTCGGCTACGCCAAAGTCAAGCTGGTAAAAGACAGCGAACTGTTCCACAACATTGAAGATGCGATCACAGAAGATGGTC
GTCCTGAGCTGGATGTGTGGATGAGTCATGGCGATAAAGTCATGGAAATTCCTGTTGATTTTGTCACGATCGCTGTAACA
CCGACTTGCCCGCATGCGGCAATGGCTAATGAAGCCAAACGTTTCTATGGTGTGCAATTCCATCCTGAAGTAACGCACAC
TGTACAAGGCGCCCGTATGCTGGAACGCTTTGTTAAAGAGATCTGTCACTGCGAGGCTCTGTGGACACCAGCTACCATCA
TCGAAGACGCGGTTGCGCGTATCCGTGAGCAGGTAGGTACTGACGAAGTTATTCTGGGTCTGTCCGGCGGTGTGGATTCT
TCCGTCGTTGCGATGCTGATCCACCGCGCTGTCGGTAAACAATTGACCTGTGTGTTCGTGGATAATGGCTTGCTGCGTCT
GAACGAAGGTCAGCAGGTCATGGAAATGTTCGGCGATCATTTTGGCCTGAACATTATCAAGGTAGATGCGGAAGAACGTT
TCCTGTCTGCACTGAAAGGTATTGCTGATCCTGAACTGAAACGTAAAGCGATCGGCCGTGTGTTTGTTGAAGTTTTCGAT
GATGAATCGAAAAAACTGAAAAATGCAAAATGGCTGGCGCAGGGCACTATCTATCCGGACGTGATCGAATCAGCGGCATC
CAAGACTGGTAAGGCACATGTGATCAAGTCTCACCATAACGTGGGCGGTTTGCCTGACGATATGAAGATGGGTCTGGTTG
AGCCACTGCGTGAACTGTTCAAAGACGAAGTTCGCCGCGTGGGTCTGGAACTGGGTCTGCCTTACAACATGCTGTACCGT
CATCCGTTCCCAGGCCCAGGCTTAGGCGTTCGTGTACTGGGTGAAGTGAAGAAAGAGTATTGCGACCTGCTGCGTCGTGC
TGATGCGATCTTCATTGAAGAGCTGCATAACGCCGATCTGTACAACAAAGTCAGCCAGGCATTCACTGTCTTCCTGCCGG
TACGCTCTGTTGGCGTAATGGGCGATGGTCGTAAATATGACTGGGTTGTTTCACTGCGCGCAGTAGAAACCATCGATTTC
ATGACCGCGCATTGGGCACATCTGCCTTATGACTTCCTAGGCCATGTTTCTAACCGTATTATCAATGAAATCAACGGCAT
CAGCCGCGTGGTTTATGATATTTCCGGTAAGCCGCCAGCAACGATTGAGTGGGAATAG

Protein sequence :
MSKNIHKHRILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPDGIILSGGPESVTESDSPRAPEYVFNAGV
PVLGVCYGMQTMAEQLGGKVESSDKREFGYAKVKLVKDSELFHNIEDAITEDGRPELDVWMSHGDKVMEIPVDFVTIAVT
PTCPHAAMANEAKRFYGVQFHPEVTHTVQGARMLERFVKEICHCEALWTPATIIEDAVARIREQVGTDEVILGLSGGVDS
SVVAMLIHRAVGKQLTCVFVDNGLLRLNEGQQVMEMFGDHFGLNIIKVDAEERFLSALKGIADPELKRKAIGRVFVEVFD
DESKKLKNAKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMKMGLVEPLRELFKDEVRRVGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHNADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGHVSNRIINEINGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-131 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-131 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-131 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-109 48