Gene Information

Name : guaA (PFLU5043)
Accession : YP_002874546.1
Strain : Pseudomonas fluorescens SBW25
Genome accession: NC_012660
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 5540841 - 5542418 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCCCTCGACATTCACGCCCACCGCATCCTGATCCTCGACTTCGGTTCCCAGTACACCCAGCTGATTGCCCGCCGCGT
GCGTGAAATCGGCGTGTACTGCGAACTGCACCCGTTCGACATGGATGACGAAGCGATCCGCGAATTCGCACCGAAAGGCG
TCATCCTCGCCGGTGGCCCCGAGTCCGTGCACGAAGCCAACAGCCCGCGCTGCCCGCAAGCCGTATTCGACCTGGGCGTA
CCGGTCTTCGGCATTTGCTACGGCATGCAGACCATGGCCGAGCAACTGGGCGGCAAGGTTGAAGGTTCCGAGCTGCGTGA
ATTCGGTTATGCCCGTGTGGACGTGGTCGGCAAGAGCCGCCTGCTGGACGGTATCGAAGACCACATCGACGCCGACGGCC
TGTTCGGCCTCGACGTGTGGATGAGCCACGGTGACAAAGTCACCAAGATGCCGGAAGACTTCCACATCCTGGCCAGCACC
CCGAGCTGCCCGATCGCCGGCATGTTCAGCGACGAGCGTCGCTACTACGGCGTGCAGTTCCACCCGGAAGTGACCCACAC
CAAACAAGGCGGCCGCATCCTGTCGCGCTTCATTCTCGACATCTGCGAGTGTGAAGCCCTGTGGACCCCGTCGAAAATCG
CTGAAGACGCCATCGCCCAGGTTCGTGCCCAGGTCGGCACCGACAACGTATTGCTCGGCCTGTCCGGCGGCGTTGACTCC
TCCGTGGTCGCCGCGCTGCTGCACAAAGCCATCGGCGACCAACTGACCTGCGTCTTCGTCGACAACGGCCTGCTGCGCCT
GCACGAAGGCGAGCAAGTGATGGCCATGTTCGCCGAGAACATGGGCGTCAAAGTGATCCGCGCCAACGCCGAGGACCAGT
TCCTCAACAACCTGGCCGGCGAGTCCGACCCGGAGAAGAAGCGCAAGATCATCGGCCGCACCTTCATCGACGTCTTCGAT
GCCCAGTCCAACAAACTGGACAACATCAAGTACCTCGCCCAGGGCACCATCTACCCCGACGTGATCGAGTCGGCCGGCGC
CAAGAGCGGCAAGGCCCACGTGATCAAGTCCCACCACAACGTGGGTGGCCTGCCTGAGGAAATGAACCTCAAGCTGGTAG
AACCGCTGCGCGAACTGTTCAAGGACGAAGTCCGCCGTCTGGGCCTGGAACTCGGCCTGCCGTACGACATGGTCTACCGC
CACCCATTCCCAGGCCCAGGCCTGGGCGTACGCATCCTCGGTGAAGTGAAAAAGGAATACGCCGACCTGCTGCGTCGCGC
CGACCACATCTTCATCGAGGAACTGCGCAAGGCCGACTGGTACCACAAAGTCAGCCAGGCGTTCGTGGTCTTCCAGCCAG
TTAAGTCGGTTGGCGTAGTAGGCGATGGCCGTCGTTACGCATGGGTTGTGGCCCTGCGTGCCGTAGAAACCATCGACTTC
ATGACCGCGCGTTGGGCACACCTGCCGTACGAACTGCTGGAGACTGTCAGCGGCCGTATCATCAACGAGATCGAAGGTAT
TTCGCGCGTGACGTATGACGTGTCGAGCAAGCCGCCGGCGACGATTGAGTGGGAGTGA

Protein sequence :
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVILAGGPESVHEANSPRCPQAVFDLGV
PVFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKMPEDFHILAST
PSCPIAGMFSDERRYYGVQFHPEVTHTKQGGRILSRFILDICECEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAGESDPEKKRKIIGRTFIDVFD
AQSNKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-127 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-127 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-128 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 6e-114 48