Gene Information

Name : clpC (CLJ_B3821)
Accession : YP_002864524.1
Strain : Clostridium botulinum 657
Genome accession: NC_012658
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence MecB/ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : 3.4.21.-
Position : 3828984 - 3831419 bp
Length : 2436 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGATGTTTGGAAGATTTACGGAAAGAGCTCAGAAAGTACTTATGAATGCTCAGGAAGAAGCAGAAAAATTTAAACATGG
ATATGTAGGTACAGAACATATTCTTTTAGGAATTTTGATAGAAGATGGAGTAGCCAAAGAATTATTAAATAATTTTAGTA
TAACAGAAGATAAGGTTAGACAGTTAATAGAAAGATATGAAGGAAAAGGGGAAATGGATCTTTATAAAAATGAGATTCCA
CTTACACCAAGAACAAAAAGGTTACTTGAAATGAGTCTATTAGAAGCTAGAAATTTAAATCATAATTATATAACTCCAGA
GCATATATTATTGGGATTAATAAGAGAAGCTGAGGGGGTAGCCTTTACCATTCTTTCTAATTTAGGCTTAGATGCTGAAA
GATTAAGAAAAGAGTTAATAAAGAATTTATCTGGGCAAGAAACCCCTAAAGATGAAGGTAGTAAAAAAAGTTCTAAAAGC
TCTACTCCTACATTAGATCAATTTGGAAGAGATTTAACTGAAATGGCAGAAGAGGGGAAGGTTGACCCTGTTATTGGAAG
GGATAAAGAAACCCAAAGAGTTTTAGAAATATTATGTAGAAGAACTAAGAACAATCCTTGCTTAATAGGCGAACCAGGAG
TTGGGAAAACAGCAATAGCCGAAGGCTTAGCTCAAAATATAATTAATGGAAATATACCAGAAATATTAAAAAACAAAAGA
GTAGTTACATTAGACTTAACATCTATGATAGCAGGGGCTAAGTATAGGGGTGAATTTGAGGATAGATTAAAGAAAATAAT
GGAGGAAGTAAGAAGTTCTAAGGATACAATATTGTTTATAGATGAAATTCATACAATAGTTGGAGCTGGGGCAGCAGAAG
GTGCTATAGATGCGGCAAACATATTAAAACCAGCATTAGCGAGAGGAGAAATTCAATGTATAGGTGCAACTACACTAGAC
GAATATAGAAAGTATATAGAAAAAGATTCTGCTTTAGAGAGAAGGTTCCAGCCTATAAACGTAGGAGAACCTACAAAAGA
AGAAACAATAGAAATTCTAAAAGGATTAAGAGATAAGTATGAAGCACATCATAGAGTTAAATTTACAGATGATGCTATAT
ATGCAGCAGTTAATTTATCTGATAGATATATAAGAGATAGATTTTTGCCAGATAAAGCCATAGATCTGATGGATGAAGCT
GGTTCCAAGGTTAGAATACAAAATTTAATTGCACCACCAGATTTGAAGAATATAGAAGAACAACTAGATAAAGTTGTTAA
AGAAAAAGAAGATGCAATAAGAGTACAGGATTTTGAAAAAGCTGCTAATTTAAGAGATAAAGAAAAAGAATTAAAAGAAA
AGTTAGAAGGGTTAAAAAAGGATTGGAATGCAGAAAAAGAAGGTTCTAATTTAATTGTATCAGAACAACAAATAGCAGCA
GTGGTTTCAAATTGGACTAATATACCAGTTAATAAGCTTACTGAAAAGGAATCTGAAAGACTCTTAAAATTAGAAGATAT
TCTTCATAATAGGGTAATTGGCCAAGAAGAAGCTATTAAATCAGTATCAAGATCTGTAAGAAGAGCAAGAGTAGGCTTAA
AAGATCCAAAGAGACCAATAGGTTCATTTATATTTTTGGGACCAACAGGTGTAGGGAAAACTGAATTAACTAAAGCTTTA
GCAGAAGCTATGTTTGGAAATGAAAATAATATGATTAGGGTTGACATGTCAGAATATATGGAAAAACATTCAGTATCTAG
ATTAATAGGATCACCCCCAGGATATGTAGGGCATGATGAAGGTGGTCAATTAACAGACAAGGTAAGGACAAATCCATATT
CAGTTGTTTTATTCGATGAAATAGAAAAAGCTCATCCAGAAGTTTTTAATATATTACTTCAAATATTAGAAGATGGAAGG
CTTACAGATGGAAAAGGAAAAACAGTAGATTTTAGAAATACTATAATTATAATGACATCTAATGTGGGAGCATCAACTAT
AAGTAGGCAAAAGACATTAGGTTTTAATACCTCTATAGAAGAAGAAAGAGAAACAGAATATGAAAAAATGAAGGATAACA
TTATGAATGAGTTAAAACATTCATTTAGGCCAGAATTCTTGAATAGAATAGATGATATAATAGTTTTCCATCAATTAAGA
GAAGAGCATATTAGAGAAATAGTTAAACTTATGCTAAAAACTGTATCAAATAGAGTCAAAGATCAAGGAATAGAATTAGA
GTTTACAGAAGAAGCAGAAAAAATATTAGCAAAAGAAGGATACGATACTAATTATGGAGCGAGACCTTTAAGAAGAGCTA
TAACTAAAATTGTAGAAGATAAATTGTCAGAAGAAATATTAAAGGGAAATATTAAAAAAGGTGATTCAGTTAAAGTTAAT
ACAATTGAAGATGAATTAAATTTTTGTAAGATATAA

Protein sequence :
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIINGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIELEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDELNFCKI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 56

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_002864524.1 negative regulator of genetic competence MecB/ClpC VFG0079 Protein 0.0 60
clpC YP_002864524.1 negative regulator of genetic competence MecB/ClpC VFG0080 Protein 1e-150 52