Gene Information

Name : guaA (CLJ_B3575)
Accession : YP_002864287.1
Strain : Clostridium botulinum 657
Genome accession: NC_012658
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3575068 - 3576600 bp
Length : 1533 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAATAAAGAATTAGTATTAGTAGTTGACTTTGGAGGTCAATATAATCAGTTAATAGCAAGACGTGTAAGGGAAAATAG
AGTGTATTGTGAAATAGTACCTTATACTACTTCTATAGAAGATATAAAAGAAAAAGCACCAAAGGGAATAATATTTACAG
GTGGTCCTAATAGTGTATATGGAGAAAATGCACCAAGAGTTCAAAAAGAATTATTTGATTTAGGTATTCCAGTCTTAGGT
ATATGTTATGGAGATCAACTTATGGCACATAGCTTAGAAGGTGAAGTAACAAGTCCTGAAAAAAGAGAATATGGTAAAAC
AGATGTAAATTTAGATAATAGTAGTTTATTGTTTAAGGATATGAAAGAGAAAGATCAATGCTGGATGAGTCATACAGATT
ATATTTCAAAGGTTCCAAAAGGATTTAAAATTATAGCAACAACAGATGAGTGCCCTTGTGCAGCTATGGAAAATGCGGAA
AAAAAATTATATGGAGTTCAATTTCATCCAGAGGTAGAGCATACTTTATTTGGCAAAAAAATGCTTAAAAACTTTTTGTT
TAACGTATGTAATTTAAAAGGTGATTGGACTATGAGTTCTTTTGCAGAGCAGCAAATAAAAGCTATAAAGGAAAAAGTAG
GAAATAAAAAAGTAATATGCGCTCTATCAGGTGGAGTAGATTCATCAGTAGCAGCAGTAATTGTTCATAAAGCTATAGGG
AAACAATTAACTTGTATATTTGTTGATCATGGTTTACTTAGAAAAGATGAAGGAGATCAAGTAGAAAAAATATTTAAAGA
TCAATTTGATATGAATTTAATAAGAGTTAATGCTCAAGATAGATTTTTAGGAAAATTAAAAGGAGTTTCAGATCCAGAAA
GAAAAAGAAAAATAATTGGAGAAGAATTTATAAGAGTATTTGAAGAAGAAGCTAAAAAATTAGGTGATATAAGTTTCTTA
GTTCAAGGTACCATATATCCTGATATAGTAGAAAGTGGAACAAACACATCAGCTACTATAAAAAGCCACCACAATGTAGG
TGGGCTGCCAGAAGACATGGAATTTAAATTAATAGAACCTTTAAGAGAATTGTTTAAAGATGAAGTAAGAGCTGTTGGAG
AAGAATTAGGTATACCACATAAATTAGTATGGAGACAGCCATTCCCAGGACCAGGTTTAGCTATAAGAGTATTAGGTGAG
GTTACAGAGGAAAAATTAGCTATTACAAGAGAAGCAGATGCTATATTCAGAGAAGAGATAGCTAAAGCAGGCTTAGAAGA
AAAAATATGGCAATATTTTGCTTGCCTTCCAAACATACAATCAGTAGGAGTAATGGGAGATGAAAGAACATATTGCCATA
CAATAGCATTAAGAGCTGTTACATCTTCAGATGCGATGACTTCAGATTGGGCAAGAATACCTTATGAAGTATTAGATAAA
GTATCAAGAAGAATAGTAAATGAGGTTAAAGAAGTAAACAGAATCGTGTATGATGTAACTTCAAAACCACCAGCAACTAT
TGAATGGGAATAA

Protein sequence :
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWTMSSFAEQQIKAIKEKVGNKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-161 63
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-162 63
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-162 63
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-143 55