Gene Information

Name : hemC (RAF_ORF0699)
Accession : YP_002845332.1
Strain : Rickettsia africae ESF-5
Genome accession: NC_012633
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 730349 - 731404 bp
Length : 1056 bp
Strand : -
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence : 
ATGACAAATTCTATCAGAATAGGTACAAGAAAAAGTCCACTTGCTTTAATACACACTAATTTAGTTATTCAGCAAATCAA
ACAATTTTTTCCTGATATCAATTGTGAAATAGTGCCGATTATTACTAGTGGGGATTTAATCCAAAATAAACCATTATACG
ATATAGGCGGTAAAGCTTTATTTTTAAAGGAAATAGAGCAAGCCTTGCTTGATAAAAAAATTGACTTAGCTGTTCATTCT
TTAAAAGATGTACCGGGTAGAATACCTGAACCGCTAGTAATAGCTGCTGTTTTAGAGCGTGAAGACCCCAGAGATGTTTT
TGTTTGTCTAAAATATAAATCTATAGAAGAGCTGCCGCAAAATGCCGTAATAGGTAGCTCGGCAGTACGAAGAAAAGCAT
TTATCCAAAAAATAAGACCGGATTTAAAGGTAACGGTTTTTAGAGGGAATGTTGATTCAAGAATAAAAAAGCTAATGACC
GGCGAAGTTGACGCAACAATTTTAGCATATACAGGTCTTAAAAGGTTAGAGGTGTTTAATCCGGAGTATTGCCATTTGAT
AGAGTATTCACAGATGTTACCGTGTATAGGGCAGGGAGTCATTGCAGTTGAGATTAGAAAAGATGATAATGCTATGCTTG
AGATATGCAATCAAATTAATCATCTTCCCACTTTTGAACTCATAAAACCCGAAAGAGCATTTTTAGAGTATCTAGATGCT
AATTGCCGCACCCCGATTGCTGCTTATTCACAATATCTAGATGCAAATCCTAGACATCTTTCCAAACTCGCTTATAGGGA
GGTATTTGAAGGAAACACAGAAGCACTTGCCACCGCAGCGTACAAAAGCAATCGCACAGATGTGAGTACCGGATTGACGT
ACAAATTACCCCTAGAAGTAGAGTTTGGGAAGGTGTCTAATATACAAACCAATTTTATGCTCGGTAACCTTGACGGCAGT
AAAATAACTTTCCATACCGAAACTACCAATATAAAAACTTCAACAGAAGCAGGCATAAAAGCCGCTAAAATGATGTTGGA
AGCTATCTGTAAATAA

Protein sequence : 
MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHS
LKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQNAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMT
GEVDATILAYTGLKRLEVFNPEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA
NCRTPIAAYSQYLDANPRHLSKLAYREVFEGNTEALATAAYKSNRTDVSTGLTYKLPLEVEFGKVSNIQTNFMLGNLDGS
KITFHTETTNIKTSTEAGIKAAKMMLEAICK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 1e-46 45
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 1e-46 45