Gene Information

Name : cadB (VCM66_0265)
Accession : YP_002809045.1
Strain :
Genome accession: NC_012578
Putative virulence/resistance : Virulence
Product : lysine/cadaverine antiporter
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0531
EC number : -
Position : 270379 - 271716 bp
Length : 1338 bp
Strand : +
Note : antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein

DNA sequence : 
ATGTCATCAAATGCAAAAAAAATCGGCCTGATCGCCTGTACGGGTGTGGTGGCTGGCAACATGATGGGCAGTGGTATTGC
GCTGCTTCCTTCTACGCTTGCGAGCGTAGGTTCAATTTCCATTTATAGCTGGCTGATCTGCATTGTTGGCGCACTCAGTT
TGGCGTTTGTGTTTGCTCGTTTGGCAACCAAAAACCCGCAAGAGGGTGGCCCGATTGCTTATGCAGGGGAAGTGTCACCG
GTGTTTGGTTTCCAAACGGGCGTGCTTTACTACCACGCTAACTGGATTGGTAATTTGGCGATTGCGATTACCGGTGTTTC
TTACCTTTCGGTGTTCTTCCCGGTGCTGAATAACCCGATCCCTGCTGGTTTAGCGACCATTGCTTCGGTTTGGCTATTTA
CCTTAGTCAACTTGCTTGGTGGTAGCTGGGTAAGCCGTTTATGTACCATTGGTTTGGTGCTGATTTTGATCCCTGTAGTC
GGTACGGCTCTGTTTGGTTGGACGCACTTTGACAGCGCGCTCTACAGCCAAAACTGGAACGTGTCTGCCGGTAGCGATGG
CCATGCGGTGATCACTGCAGTGCTGATCTGTCTGTGGTCTTTCGTGGGTGTTGAATCGGCAGCGGTTTCTTCCGGTATGG
TCGAAAACCCAAAACGCACGGTGCCACTGGCAACCATGTTAGGTACTGGTCTTGCGGGCCTTATCTATGTGCTATCAACT
CAAATGATCAGCGGTATGTTCCCTGCCTCTGAAGTGGCGGCATCGGGTGCACCTTTTGCACTGGCGACCACAGCACTGTT
TGGTAGCTGGACTGCGCCATTCGTGTCTGCCTTTACTGCACTAGCGTGTTTCACGTCACTTGGCTCTTGGATGATGCTGG
TCGGCGAAGCGGGCAAACGTGCCGCTAACGATGGCAACTTCCCGAAAGTATTCGGTGAAACCGATCGCAACGGTGTACCG
AAAAAAGGTCTGCTGATTGCTTCCAGCATGATGACATTGCTGATGCTGGTGCTGATGTTCTTCAGCTCAGAAACTGCGCA
CGCTTCCGATCTGTTTAACCAACTGACTACCGATGCGGTTCTGCTGACCATGCTGCCTTATTTCTACTCCAGCATTAACC
TGATCCGCTTCGAAGGCATGACCACTCGCAATACGTTTGTGATGCTGTTCTCCGGTATTGCCAGCCTGTTCTGTATGGTG
GCGCTGGCTGGTGCAGAGGGTTCAACCCTGACTGCAACCTTCATCATGTCGCTGATTATTTTGATGTTCTACAGCAAAAA
AGCGGGTCTGGATAAATACCTCGAGACTCATCCACAACAAGCTTCGGCTCAGTTCTGA

Protein sequence : 
MSSNAKKIGLIACTGVVAGNMMGSGIALLPSTLASVGSISIYSWLICIVGALSLAFVFARLATKNPQEGGPIAYAGEVSP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPVLNNPIPAGLATIASVWLFTLVNLLGGSWVSRLCTIGLVLILIPVV
GTALFGWTHFDSALYSQNWNVSAGSDGHAVITAVLICLWSFVGVESAAVSSGMVENPKRTVPLATMLGTGLAGLIYVLST
QMISGMFPASEVAASGAPFALATTALFGSWTAPFVSAFTALACFTSLGSWMMLVGEAGKRAANDGNFPKVFGETDRNGVP
KKGLLIASSMMTLLMLVLMFFSSETAHASDLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRNTFVMLFSGIASLFCMV
ALAGAEGSTLTATFIMSLIILMFYSKKAGLDKYLETHPQQASAQF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadB NP_756989.1 lysine/cadaverine antiporter Not tested PAI II CFT073 Protein 2e-127 70
cadB AAL67382.1 cadaverine/lysine antiporter Not tested PAI II CFT073 Protein 2e-127 70
unnamed CAD66196.1 putative lysin/cadaverin transporter Virulence PAI III 536 Protein 2e-132 68

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadB YP_002809045.1 lysine/cadaverine antiporter VFG1671 Protein 1e-132 68