Gene Information

Name : zntA (VCM66_0988)
Accession : YP_002809757.1
Strain :
Genome accession: NC_012578
Putative virulence/resistance : Resistance
Product : zinc/cadmium/mercury/lead-transporting ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 1055077 - 1057383 bp
Length : 2307 bp
Strand : +
Note : P-type ATPase involved in the export of lead, cadmium, zinc and mercury

DNA sequence :
ATGTGTACTAAACACCATGCTTGTCGTTCAAAATCGTTAACTCAACCTATGCACAGCCACCAAACGAGCTGTGACGGAAG
CCCCAAAATTGTCGCCATTCGTGCGGCAGGCGTAAGCGCTTCTTGTGACGGCGATAGTTGCTGTACCAGTGATGGTGGTG
GCGGTGCGACGTTGGAAGAAGACCCCGAGCGACGTCACGAACCACGTTCATCACACTATCAGCAGAGTTGGTATATCGCA
GGAATGGACTGTCCTTCTTGCGCACAAAAAATTGAAAAAGCCGTTAAGCAGTTGGGTGATGTCACTCAAGTGCAGGTGAT
GTTCGCCACTCAGAAATTGGTGGTTGGCTTTAATCAACCCTCAACCGCGCCGCTTATCGAACAAGCAGTACGCGACAGCG
GTTTTAGCCTAAACCCAGCCGCCAGTTCAGCGGCAACACCATCCCAATCCAAGCCGCCCCTCTGGCAGAGTGAAAACGCA
CGAATTATCGGTATCGCTGCGCTGATGGCAATAGGTGCCTTAGTCAACTCCAGCGAGATGAGCCGCTGGATTTATACGCT
GACTTGTCTATTGGGGCTGTTCCCCATCCTTCAACAAGCTTGGCGTCTTGCCAAATCGGGTTCTCCTTTCTCGATTGAAA
CCTTAATGTCGGTTGCCGCAATTGGCGCGCTTTATTTGGGGGAAACCTTAGAAGCCGCCATGGTATTACTGCTGTTTTTG
ATTGGTGAGCGCTTGGAGGCTTATGCCGCTTCTCGGGCACGTACGGGCGTACAAGCCTTGATGGCGCTGGTGCCAGAAAC
GGCGATTCGTATAGAACATGGAGAGCGTGTTACCGTTCCTGCCGCGCAGTTGCAACCGGGCGATGTCATTGAAGTGGCTC
CCGGAGGTCGTTTACCAGCGGATGGGCGCTTACTTGCCGCCGCCAGTCTGGATAACAGTGCGTTAACGGGCGAATCCTTA
CCTGTCGAATTAACGGCAGGGGAGCGAGTTTCTGCAGGTTGTGTGATCGTGGATAAGGTGGTGCAGATTGAAATCACCTC
GAAACAAGGTGAAAACGCCATCGACCGTATTTTGCATATGATTGAAGAGGCGGAATCGCGCAAAGCACCCCTGGAGCGTT
TTTTAGATAAATTCAGTCGTTGGTATACCCCGCTGATGATGCTGGTCGCGCTCGCCGTGATTGTGGTCCCGCCATTAGCG
TTTGGTGCCGATTGGCAGACTTGGATTTACCGTGGCCTTGCTTTGCTGCTCATCGCTTGTCCTTGTGCGCTAGTGATCTC
CACACCTGCGGCGATCACTTCGGGTTTGGCGGCGGCGGCGCGTCGTGGGGCTTTAATTAAAGGTGGTGCGGCATTAGAGC
AATTGGGAAAAATCGAGACCATTGCCTTTGATAAGACAGGCACCTTGACCGAAGGTAAACCGCAAGTCACAGACCTTATC
CCGCTGCAAGGTTGGGATAGCGCGACCTTGTTAGCTCGGGCTGCTGCGATTGAGATGGGCTCACATCATCCCTTAGCGAC
CTCGCTGGTGGCAAAAGCGCAGGCGGAGCAACTGACCATCCCACAAGCGCAAGAGCGTACCGCCTTGGTTGGGCGAGGCA
TTAGCGGCCAGATTGATGGTGTTCAGTATCGTCTGCTTGCGCCAAATCGGGTCGAAACCAAATTGCCCGACGTGGTGAAA
CAGCATGTCGAAATGCTTGAAGCTGAAAGTAAAACCGTAGTCGTGATGCTGGCAAGTGACGCGGTGGTTGGTGTGATTGC
TTGGCAAGACACGCTGCGCAGTGATGCACGTCAAGCGGTCGCCGCCTTACATCAACTCGGGATTAACGCCTTGATGCTGA
CGGGAGACAACGAACGCAGCGCGGCCGCAATGAGCCAGCAACTGAATATGGATTTTCGGGCAGGTTTATTGCCGCAAGAT
AAAGTCGGCTACATTCAGCAGTTGGCGCAACATCAACGTGTCGCCATGGTGGGCGATGGCATTAACGATGCCCCAGCCAT
GAAAGAGGCGAGTATTGGTATCGCAATGGGCGGCGGCACCGACGTCGCGCTAGAAACCGCCGATGCAGCACTGACTCACA
ATCGCTTGATTGAGTTGCCGGGGATGATTGAGCTGTCTCGTGCTACGTTGGCCATCATTCGCCAAAACGTGGTCTTAGCC
TTGGGACTTAAAGCGGTGTTCTTAGTCACCAGTTTACTTGGCATCACCGGATTATGGATGGCGGTATTGGCCGACAGCGG
TGCAACCGCACTGGTCACGCTCAATGCACTGCGTCTGCTTAAATTCCGCTCTTCGACTTCGGAATAA

Protein sequence :
MCTKHHACRSKSLTQPMHSHQTSCDGSPKIVAIRAAGVSASCDGDSCCTSDGGGGATLEEDPERRHEPRSSHYQQSWYIA
GMDCPSCAQKIEKAVKQLGDVTQVQVMFATQKLVVGFNQPSTAPLIEQAVRDSGFSLNPAASSAATPSQSKPPLWQSENA
RIIGIAALMAIGALVNSSEMSRWIYTLTCLLGLFPILQQAWRLAKSGSPFSIETLMSVAAIGALYLGETLEAAMVLLLFL
IGERLEAYAASRARTGVQALMALVPETAIRIEHGERVTVPAAQLQPGDVIEVAPGGRLPADGRLLAAASLDNSALTGESL
PVELTAGERVSAGCVIVDKVVQIEITSKQGENAIDRILHMIEEAESRKAPLERFLDKFSRWYTPLMMLVALAVIVVPPLA
FGADWQTWIYRGLALLLIACPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGKIETIAFDKTGTLTEGKPQVTDLI
PLQGWDSATLLARAAAIEMGSHHPLATSLVAKAQAEQLTIPQAQERTALVGRGISGQIDGVQYRLLAPNRVETKLPDVVK
QHVEMLEAESKTVVVMLASDAVVGVIAWQDTLRSDARQAVAALHQLGINALMLTGDNERSAAAMSQQLNMDFRAGLLPQD
KVGYIQQLAQHQRVAMVGDGINDAPAMKEASIGIAMGGGTDVALETADAALTHNRLIELPGMIELSRATLAIIRQNVVLA
LGLKAVFLVTSLLGITGLWMAVLADSGATALVTLNALRLLKFRSSTSE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 9e-84 43
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 9e-84 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
zntA YP_002809757.1 zinc/cadmium/mercury/lead-transporting ATPase BAC0461 Protein 2e-148 57
zntA YP_002809757.1 zinc/cadmium/mercury/lead-transporting ATPase BAC0298 Protein 5e-77 44