Gene Information

Name : ureC (Avin_09880)
Accession : YP_002798195.1
Strain : Azotobacter vinelandii DJ
Genome accession: NC_012560
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : -
Position : 938920 - 940620 bp
Length : 1701 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAAAATCAGCAGACAAGCCTACGCTGACATGTTCGGCCCCACGCTCGGCGACCGGGTGCGCCTGGCCGACACCGAGTT
GTGGATCGAGGTGGAGCAGGACTTCACCGTCTACGGCGAGGAAGTGAAGTTCGGCGGCGGCAAGGTGATCCGCGACGGCA
TGGGCCAGGGCCAGTTGGAGAGCGCCGCGGTGGTCGACACCCTGATCACCAACGCGCTGATCCTCGACCACTGGGGCATC
GTCAAGGCCGACGTCGGCCTCAAGGACGGGCGCATCGCCGCCATCGGCAAGGCCGGCAACCCGGACATCCAGCCGGGGGT
GACCATCGCCGTCGGCGCCGCCACCGAGGTGATCGCCGGCGAGGGCATGATCCTCACCGCCGGCGGCATCGACAGCCACA
TCCACTTCATCTGCCCGCAGCAGATCGAAGAGGCGCTGATGAGCGGCATCACCACCATGATCGGCGGCGGCACGGGACCG
GCCACCGGCACCAACGCCACCACCGTCACGCCCGGTCCCTGGCACATCGCGCGCATGCTGCAGGCCGCCGACGCCTTCCC
GATGAACCTGGGCTTCACCGGCAAGGGCAACGCCAGCCTGCCGGGCCCCCTGGCCGAGCAGATCGAAGCCGGCGCCATCG
GCCTCAAGCTGCACGAGGACTGGGGCACCACCCCGGCGGCCATCGACAACTGCCTGTCCGTGGCCGACCGTTACGACGTG
CAGGTGGCGATCCATACCGACACCCTCAACGAGTCCGGCTTCGTCGAGACCAGCCTGGCCGCCTTCAAGGACCGCACCAT
CCACACCTACCACACCGAGGGCGCCGGCGGCGGCCACGCGCCGGACATCATCAAGGCCTGCGGCCTGCCCAACGTGCTGC
CCAGCTCGACCAACCCGACCCGGCCGTTCACCCGCAACACCATCGACGAACACCTGGACATGCTGATGGTCTGCCACCAC
CTCGATCCGAGCATCGCCGAGGACGTGGCCTTCGCGGAAAGCCGCATCCGCCGCGAGACCATCGCCGCCGAGGACATCCT
CCACGACCTCGGCGCCTTCAGCATGATCTCCTCGGACAGCCAGGCCATGGGCCGGGTCGGCGAAGTGATCGTCCGCACCT
GGCAGACCGCCGACAAGATGAAGAAACAGCGCGGCCCGCTGCCCGAGGACGTCGCCGGCCACGACAACTTCCGCGTCAAG
CGCTACGTCGCCAAGTACACCATCAACCCGGCGATCACCCACGGCATCAGCCACGAGGTCGGCTCGGTGGAGGTCGGCAA
GTGGGCCGACCTGGTGCTCTGGCGGCCGGCCTTCTTCGGCGTGAAACCCTCGCTGATCCTCAAGGGCGGCGCCATCGCCG
CGAGCCTGATGGGCGACGCCAACGCCTCCATCCCCACCCCGCAGCCGGTGCACTACCGGCCGATGTTCGCCAGCTTCGCC
GGCTCGCGCCACGCCACCAGCATCACCTTCGTCAGCCAGGCGGCGCTGGCCGCCGGGGTGCCGGAACGACTCGGTTTGCA
CAAGCGCATCGGCGTGGTCAAGGGCTGCCGGAACGTGCGCAAGAAGGACCTGATCCACAACGGCGCCACCCCGACCATCG
AGGTCGATCCGCAGACCTACCAGGTCAAGGCCGACGGCCAGTTGCTCTGGTGCGAACCGGCCGAGGTGCTGCCGCTGGCG
CAGCGTTATTTCCTCTTTTGA

Protein sequence :
MKISRQAYADMFGPTLGDRVRLADTELWIEVEQDFTVYGEEVKFGGGKVIRDGMGQGQLESAAVVDTLITNALILDHWGI
VKADVGLKDGRIAAIGKAGNPDIQPGVTIAVGAATEVIAGEGMILTAGGIDSHIHFICPQQIEEALMSGITTMIGGGTGP
ATGTNATTVTPGPWHIARMLQAADAFPMNLGFTGKGNASLPGPLAEQIEAGAIGLKLHEDWGTTPAAIDNCLSVADRYDV
QVAIHTDTLNESGFVETSLAAFKDRTIHTYHTEGAGGGHAPDIIKACGLPNVLPSSTNPTRPFTRNTIDEHLDMLMVCHH
LDPSIAEDVAFAESRIRRETIAAEDILHDLGAFSMISSDSQAMGRVGEVIVRTWQTADKMKKQRGPLPEDVAGHDNFRVK
RYVAKYTINPAITHGISHEVGSVEVGKWADLVLWRPAFFGVKPSLILKGGAIAASLMGDANASIPTPQPVHYRPMFASFA
GSRHATSITFVSQAALAAGVPERLGLHKRIGVVKGCRNVRKKDLIHNGATPTIEVDPQTYQVKADGQLLWCEPAEVLPLA
QRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 73
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 73
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-163 63
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-163 63
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 4e-163 63
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-163 63

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_002798195.1 urease subunit alpha VFG0270 Protein 8e-161 66