Gene Information

Name : guaA (LHK_00777)
Accession : YP_002794779.1
Strain : Laribacter hongkongensis HLHK9
Genome accession: NC_012559
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 744171 - 745748 bp
Length : 1578 bp
Strand : -
Note : GMP synthase [glutamine-hydrolyzing]; contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGACAAGATCCTCATCCTCGATTTCGGCTCGCAGGTCACGCAGCTGATTGCCCGCCGCGTGCGCGAAGCCCATGTTTA
TTGCGAACTGCACCCGTACGACATGTCCATCGAGGACATCCGCGCCTTCAATCCCAAAGGCATCATCCTGTCGGGCGGCC
CGAACTCGGTGTACGAATCGGACTACCAGGCCGATCCGGCCCTGTTTGACCTCGGCGTGCCGGTGTTCGGCATCTGCTAC
GGCATGCAGTTCATGGCCCACACCCTGGGTGGTACCGTGGAAGCCGGCGACCAGCGCGAATTCGGCTACGCCGAAATCCG
CGCCCGCAACCACTCCAAGCTGCTCGAAGGCCTGCAGGACCGCAGCAACGACGCCGGTCACGGCCTCTTGGACGTGTGGA
TGAGCCACGGAGACAAGGTCACCGCCCTGCCGGCCGGCTTCAAGGTCATCGCCGAAACCCCGTCCTGCCCGATTGCCGCC
ATGGCCGACGAAACCCGCCATTACTACGGTGTGCAGTTCCACCCGGAAGTGACCCACACCAGGCGCGGCACCGAAATGAT
CCACCGCTTCGTGCTGCACATCTGTGGCGCCGAGCCAAGCTGGACCATGCCGAACTACATCGACGAAGCCGTGAAGAAAA
TCCGCGAACAGGTCGGTGACGAAGAAGTCATCCTTGGCCTCTCGGGCGGTGTCGACAGCTCGGTAGCCGCCGCGCTGATC
CACCGCGCCATCGGCGACCAGCTCACCTGCGTGTTTGTCGACCACGGCCTCCTGCGCCTCAACGAAGGCGAGATGGTCAT
GGACATGTTCGCCCGCAACCTCGGCGTGAAAGTGATCCACGTCGATGCCAGCGCCGAATTCATGGGTAAGCTCGCCGGCG
TCACCGACCCGGAACAGAAACGCAAGATCATCGGCGCCGAATTTGTCGCAGTGTTCCAGCGCGAAGCTGAAAAACTGCCG
AAAGCCAAGTGGCTGGCACAAGGTACCATTTACCCGGACGTGATCGAATCGGCCGGTGCCAAGACCCAAAAAGCCCACAC
CATCAAGAGCCACCACAACGTGGGCGGCCTGCCGGAAACGCTGAACCTGAAGCTTCTGGAGCCGCTGCGCGAACTCTTCA
AGGACGAAGTGCGCCAGCTCGGCATCGCACTGGGCCTGCCGCACGAAATGGTCTATCGCCACCCGTTCCCGGGCCCGGGT
CTGGGCGTGCGCATTCTGGGCGAAGTGAAGGCCGAATACGCCGAGCTGCTCAAGCGTGCCGACGCCATCTTCATCGAAGA
GCTGCGCAACACCATCGACGAAAAAACCGGCAAGAGCTGGTACGACCTGACCAGCCAGGCCTTTGCCGTGTTCCTGCCGG
TCAAGTCGGTCGGCGTGATGGGCGACGGCCGCACCTACGACTACGTCGTGGCCCTGCGCGCCGTGGTCACCAGCGACTTC
ATGACCGCCCACTGGGCCGAGCTGCCCTACAGCCTGCTGGGCCGGGCATCGAACCGCATCATCAACGAAGTTCGTGGTCT
GAACCGGGTTGTCTACGATGTATCGGGCAAGCCGCCGGCGACGATTGAGTGGGAGTGA

Protein sequence :
MDKILILDFGSQVTQLIARRVREAHVYCELHPYDMSIEDIRAFNPKGIILSGGPNSVYESDYQADPALFDLGVPVFGICY
GMQFMAHTLGGTVEAGDQREFGYAEIRARNHSKLLEGLQDRSNDAGHGLLDVWMSHGDKVTALPAGFKVIAETPSCPIAA
MADETRHYYGVQFHPEVTHTRRGTEMIHRFVLHICGAEPSWTMPNYIDEAVKKIREQVGDEEVILGLSGGVDSSVAAALI
HRAIGDQLTCVFVDHGLLRLNEGEMVMDMFARNLGVKVIHVDASAEFMGKLAGVTDPEQKRKIIGAEFVAVFQREAEKLP
KAKWLAQGTIYPDVIESAGAKTQKAHTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRQLGIALGLPHEMVYRHPFPGPG
LGVRILGEVKAEYAELLKRADAIFIEELRNTIDEKTGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVVTSDF
MTAHWAELPYSLLGRASNRIINEVRGLNRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-127 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-127 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-127 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-110 50