|
Name : ureC (ROP_57400) Accession : YP_002782932.1 Strain : Rhodococcus opacus B4 Genome accession: NC_012522 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 6269338 - 6271059 bp Length : 1722 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGACCGATCTCAGCCGCGCCCGGTACGCCGAGTTGTTCGGCCCGACCACGGGCGACCGGATCCGGCTCGCCGACACCGA CCTCCTGATCGAGATCACCGAGGACCGCGGCGGCGGGCCCGGACTGGCCGGTGACGAGGCGGTGTTCGGTGGCGGAAAAG TGTTGCGCGAGTCCATGGGCCAGGGCCGGGCGACCCGCGCCGAGGGTGCGCCCGACACGGTGATCACCGGGGTCGTGGTG GTCGATCACTGGGGAATCATCAAGGCGGACGTCGGTATTCGGGGTGGACGCATCGTCGCGCTCGGCAAGGCGGGCAACCC CGACACGATGTCGGGCGTCCACCCCGATCTCGTGGTGGGGCCGTCCACCGAGATCATCGCCGGCAACGGCAAGATCCTCA CCGCAGGCGGTATCGACTGCCACGTGCACTTCATCTGCCCGCAGATCATGGACGAGGCGCTGGGCGGCGGCATCACGACG ATGATCGGCGGCGGCACCGGCCCCGCCGAGGGCAGCAAGGCCACCACCGTCACCCCCGGTTCCTGGCACACCGCCCGGAT GCTGGAGGCGCTCGACGGCTGGCCGATGAACATCGCCCTGCTCGGCAAGGGCAACACGGTCAGCTCCGAGTCGATGTGGG AGCAGTTGCGCGGCGGCGTCTCCGGGTTCAAGCTGCACGAGGACTGGGGTTCGACTCCGGCGGCCATCGACGCGTGCCTC ACCGTCGCGGACGCTGCGGGAGTGCAGGTGGCCCTCCACTCGGACACGTTGAACGAGGCCGGCTTCGTCGAGGACACTCT CGCGGCCATCGCCGGCCGGGCGATCCACGCCTATCACACGGAGGGGGCGGGCGGCGGCCACGCGCCGGACATCATCACGG TGGCCGCGCACGCGAACGTCCTGCCGAGTTCGACCAACCCGACCCGGCCGCACACGGTCAACACGCTCGACGAGCACCTC GACATGCTCATGGTGTGCCATCACCTGAGCCCGAAGATCCCGGAGGACCTGGCGTTCGCGGAAAGCCGCATCCGGCCGTC CACCATCGCGGCGGAGGATCTGCTCCACGACCTCGGCGCCATCTCCATGATCGGCAGCGACTCGCAGGCGATGGGACGCA TCGGCGAGGTCGTGTTGCGCACGTGGCAGACGGCGCACGTGATGAAGCGCCGACGGGGTTTCCTGGCAGGCGACAACGGC GCCGACAACCAGCGCGTCCAACGCTACGTGGCGAAGTACACGATCTGCCCCGCCGTCGCGCACGGGCTGGAGGACGAGAT CGGATCGGTCGAGGTCGGCAAGCTCGCCGACCTGGTGCTGTGGGATCCGGCGTTCTTCGGTGTCCGGCCGCACGCGGTGA TCAAGGGCGGGATGATCGCGTGGGCCGCCATGGGAGATGCCAACGCGTCCATACCGACTCCGCAACCGGTGCTTCCGCGC CCGATGTTCGGGGCGGCGCCCAAGGCGGCGGCCGCCACGTCCGTGCACTTCGTCGCACCGCACGCGCTCGAGGACGGACT GGCGGATCGGCTGGACCTGAGCCGTCGGCTGGTGCCGGTCGCGAACGTGCGGTCGCGGGGCAAGGCCGACATGCCCCGCA ACGACGCGCAGCCGCGGATCGAGGTGGACCCGGACACGTTCACGGTCCGCATCGACGGCGACGTGTGGGAAGAGCAGCCG GCGGCGGAACTGCCGATGGCCCAGCGATACTTCCTGTTCTGA Protein sequence : MTDLSRARYAELFGPTTGDRIRLADTDLLIEITEDRGGGPGLAGDEAVFGGGKVLRESMGQGRATRAEGAPDTVITGVVV VDHWGIIKADVGIRGGRIVALGKAGNPDTMSGVHPDLVVGPSTEIIAGNGKILTAGGIDCHVHFICPQIMDEALGGGITT MIGGGTGPAEGSKATTVTPGSWHTARMLEALDGWPMNIALLGKGNTVSSESMWEQLRGGVSGFKLHEDWGSTPAAIDACL TVADAAGVQVALHSDTLNEAGFVEDTLAAIAGRAIHAYHTEGAGGGHAPDIITVAAHANVLPSSTNPTRPHTVNTLDEHL DMLMVCHHLSPKIPEDLAFAESRIRPSTIAAEDLLHDLGAISMIGSDSQAMGRIGEVVLRTWQTAHVMKRRRGFLAGDNG ADNQRVQRYVAKYTICPAVAHGLEDEIGSVEVGKLADLVLWDPAFFGVRPHAVIKGGMIAWAAMGDANASIPTPQPVLPR PMFGAAPKAAAATSVHFVAPHALEDGLADRLDLSRRLVPVANVRSRGKADMPRNDAQPRIEVDPDTFTVRIDGDVWEEQP AAELPMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-159 | 61 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-159 | 61 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-154 | 57 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-154 | 57 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-154 | 57 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-154 | 57 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002782932.1 | urease subunit alpha | VFG0270 | Protein | 7e-139 | 55 |
