Gene Information

Name : mccB (BBR47_47850)
Accession : YP_002774266.1
Strain : Brevibacillus brevis NBRC 100599
Genome accession: NC_012491
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 5033816 - 5034949 bp
Length : 1134 bp
Strand : -
Note : catalyzes the formation of L-homocysteine from cystathionine

DNA sequence :
ATGCGCATCAAAACTCGTCTGATCCACGGCGGAATCGATGGAGATCCACATACAGGAGCCGTATCCGTTCCAATTTACCA
GGTAAGTACGTATAAACAGGAAGCCATTGGCGTTCACAAAGGCTTCGAATATTCCCGTACGGGGAATCCGACCCGTCACG
CATTGGAAACATACATCGCAGAAATCGAAGGCGGCGCACGCGGCTTTGCATTTGGTTCTGGGATGGCGGCACTGTCTACC
ATCCTCTCGATGTTCAACAAAGGCGATCATCTCGTAGTAGGGGACGATGTATACGGTGGTACTTACCGCGTCGTTACACG
TGTATTCTCCCGTATGGGTCTGGAAGCAACCTACGTAGATACGAGTGATCTGGCAGCAGTAGAGGCGGCAATTCGCCCGG
AAACCAAAGCAATCATTATGGAAACACCGACAAACCCGCTACTGAAAGTAAGCGACATCAGCGCGTTGGCAGGAATCGCG
AAAGCAAAAGGCGTGCTGCTCGTAGTAGACAACACGTTCATGACGCCATACTGGCAAAATCCGCTGGATCTCGGTGCTGA
CATCGTGTTCCATAGCGCAACAAAATATTTGGGCGGACACAGCGACGTAGTAGCTGGTCTGGTTGTAGCAAAAGATGCGC
AAGTGGGCGAAGACCTCCATTTTGTGCAAAATGCAATTGGCGGTGTGCTTGGACCACAAGATTCTTGGCTCTTGCTGCGC
GGTATGAAGACGCTGGGAATTCGGATGGAAGAGCATGAACACAATGCTCGTACGCTCGCAAAATGGCTGTCTGAGCGCAG
CGACATCAAACGCGTCATTTATCCTGGTCTGTCCAGCCATTCCGGTCATGAGCTGATTCAAAAGCAAGCGCGTGGCTTCG
GTGGCATGATTTCCTTCGACGTAGGTAGCGCAGAGCGTGCTGACGAAGTGTTGGCAAAGGTAAAATACTACACGCTGGCA
GAATCGCTGGGTGCAGTGGAGAGCTTGATCAGCGTACCTGCACGCATGACACATGCTTCTATCCCGGCAGAGCGCCGTGC
TGAGCTGGGTATTACAGATGGCCTGGTGCGCATCTCTGTTGGTATTGAAGATGTTCAGGACTTGATCGAGGACCTCGACC
AAGCATTGTCCTAA

Protein sequence :
MRIKTRLIHGGIDGDPHTGAVSVPIYQVSTYKQEAIGVHKGFEYSRTGNPTRHALETYIAEIEGGARGFAFGSGMAALST
ILSMFNKGDHLVVGDDVYGGTYRVVTRVFSRMGLEATYVDTSDLAAVEAAIRPETKAIIMETPTNPLLKVSDISALAGIA
KAKGVLLVVDNTFMTPYWQNPLDLGADIVFHSATKYLGGHSDVVAGLVVAKDAQVGEDLHFVQNAIGGVLGPQDSWLLLR
GMKTLGIRMEEHEHNARTLAKWLSERSDIKRVIYPGLSSHSGHELIQKQARGFGGMISFDVGSAERADEVLAKVKYYTLA
ESLGAVESLISVPARMTHASIPAERRAELGITDGLVRISVGIEDVQDLIEDLDQALS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-105 58
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-106 58
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 5e-77 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mccB YP_002774266.1 cystathionine beta-lyase BAC0207 Protein 5e-65 43