Gene Information

Name : megL (BCA_4769)
Accession : YP_002752013.1
Strain : Bacillus cereus 03BB102
Genome accession: NC_012472
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 4455735 - 4456913 bp
Length : 1179 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence : 
ATGAAAAAGAAGCATATGGAGACAGCGTTAATTCATCACGGTTATACATCTGAGGAACATAAAGGAAGTTTAACACCACC
GTTATTTCAAACGTCTACATTTACATTTGAGACTGCGCAGCAAGGAGAGGCGAGTTTTGCGGGAGTGGATCCATCTTATA
TTTACTCAAGACTTGGAAATCCAACTGTGAAATTATTTGAAGAACGTATGGCGGTGTTAGAAGGAGGAGAAGAAGCACTT
GCTTTCGGATCCGGTATGGCAGCTATTTCAGCAACGTTAATTGGCTTTTTAAAAGCTGGAGATCATATTATTTGTTCAAA
TGGATTATATGGGTGCACGTATGGATTTTTAGAAGTGTTAGAAGAGAAATTTATGATTACGCATTCGTTTTGTGATATGG
AGACAGAGACTGATATTGAAAATAAAATCCGTCCAAATACGAAGCTTGTTTTCGTTGAAACACCGATTAATCCGACAATG
AAATTAATTGATTTAAAACAAGTGATTCGAGTTGCGAAGCGAAATGGATTACTTGTCATTGTTGATAATACGTTTTGTTC
ACCTTATTTACAAAGACCGCTTGAACTTGGCTGTGACGCCGTTGTTCATAGTGCGACAAAATATATTGGTGGTCACGGTG
ATGTTGTGGCGGGTGTAACAATTTGTAAAACGAAAGCGTTAGCTGAAAAAATCCGCCCGATGCGAAAAGATATCGGCGGT
ATTATGGCACCGTTTGATGCATGGTTATTGTTACGCGGATTAAAGACACTAGCGGTAAGAATGGACCGCCATTGTGATAA
TGCAGAAAAAATTGTATCGTTTCTAAAAAATCATGATGCGGTAGAAGGTGTTTGGTATCCAGAAGGGGAGTTAGCATCTC
GCCAAATGAAACGGGGCGGCGGCGTTATATCTTTTTCAATTAAAGGCGGGAAAGAAGAGACGCAGGCGTTTATTAATGAC
CTTCACTTTATTACAATTGCGGTAAGTTTAGGAGATACAGAAACGTTAATTCAGCACCCGGCAACGATGACGCACGCTGC
GATTCCAGCTGAGTTAAGACAAGAAATGGGTATTTATGATAATTTAATACGTTTATCTGTCGGTTTAGAATCGTGGGAGG
ATATCGTTTCTGATTTAGAGCAAGCATTAAAGAAAATATCTACTGTTAGTAATCAATAA

Protein sequence : 
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETETDIENKIRPNTKLVFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTKALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGGVISFSIKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-66 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-67 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_002752013.1 methionine gamma-lyase BAC0207 Protein 8e-90 48