Gene Information

Name : SP70585_0829 (SP70585_0829)
Accession : YP_002740104.1
Strain : Streptococcus pneumoniae 70585
Genome accession: NC_012468
Putative virulence/resistance : Resistance
Product : macrolide export ATP-binding/permease MacB
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG1136
EC number : 3.6.3.-
Position : 756944 - 757645 bp
Length : 702 bp
Strand : +
Note : identified by match to protein family HMM PF00005

DNA sequence : 
ATGAAGCAACTAATTAGTCTAAAAAATATCTTCAGAAGCTACCGTAATGGTGACCAAGAACTGCAGGTTCTCAAAAATAT
CAATCTAGAAGTGAATGAGGGTGAATTTGTAGCCATCATGGGACCATCTGGGTCTGGTAAGTCCACTCTGATGAATACGA
TTGGCATGTTGGATACACCAACCAGTGGAGAATATTATCTTGAAGGTCAAGAAGTGGCTGGGCTTGGTGAAAAACAACTG
GCTAAGGTCCGTAACCAACAAATCGGTTTTGTCTTTCAGCAGTTCTTTCTTCTATCGAAGCTCAATGCTCTGCAAAATGT
AGAATTGCCCTTGATTTACGCAGGAGTTTCGTCTTCAAAACGTCGTAAGTTGGCTGAGGAATATTTAGACAAGGTTGAAT
TGACAGAACGTAGTCACCATTTACCTTCAGAATTATCTGGTGGTCAAAAGCAACGTGTAGCCATTGCGCGTGCCTTGGTA
AACAATCCTTCTATTATCCTAGCGGATGAACCGACAGGAGCCTTAGATACCAAAACAGGTAACCAAATTATGCAATTATT
GGTTGATTTGAATAAAGAAGGAAAAACCATTATCATGGTAACGCATGAGCCTGAGATTGCTGCCTATGCCAAACGTCAGA
TTGTCATTCGGGATGGGGTCATTTCGTCTGACAGTGCTCAGTTAGGAAAGGAGGAAAACTAA

Protein sequence : 
MKQLISLKNIFRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSGSGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEKQL
AKVRNQQIGFVFQQFFLLSKLNALQNVELPLIYAGVSSSKRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARALV
NNPSIILADEPTGALDTKTGNQIMQLLVDLNKEGKTIIMVTHEPEIAAYAKRQIVIRDGVISSDSAQLGKEEN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
Cp1002_1464 YP_005681730.1 ABC transporter ATP-binding protein Not tested PiCp 5 Protein 9e-38 43
CpC231_1466 YP_005683828.1 ABC transporter ATP-binding protein Not tested PiCp 5 Protein 3e-39 42
cpfrc_01473 YP_003783873.1 hypothetical protein Not tested PiCp 5 Protein 3e-39 42
CpI19_1473 YP_005685914.1 ABC transporter ATP-binding protein Not tested PiCp 5 Protein 3e-39 42
SARLGA251_00480 YP_005754062.1 ABC-type transport system ATPase Not tested Type-XI SCCmec Protein 1e-32 41
cur_1502 YP_001800896.1 cell division ATP-binding protein FtsE Not tested Not named Protein 1e-34 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SP70585_0829 YP_002740104.1 macrolide export ATP-binding/permease MacB NC_012469.1.7686878. Protein 9e-107 100
SP70585_0829 YP_002740104.1 macrolide export ATP-binding/permease MacB NC_008702.1.4606598. Protein 9e-48 47
SP70585_0829 YP_002740104.1 macrolide export ATP-binding/permease MacB CP001581.1.gene798.p Protein 3e-43 46
SP70585_0829 YP_002740104.1 macrolide export ATP-binding/permease MacB CP001581.1.gene598.p Protein 1e-35 42