Gene Information

Name : SP70585_0166 (SP70585_0166)
Accession : YP_002739477.1
Strain : Streptococcus pneumoniae 70585
Genome accession: NC_012468
Putative virulence/resistance : Virulence
Product : CapD protein, required for the biosynthesis of type 1 capsular polysaccharide
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1086
EC number : -
Position : 141208 - 143058 bp
Length : 1851 bp
Strand : +
Note : identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993

DNA sequence :
ATGAATAAAAAACTCACAGATTATGTGATTGATCTGGTGGAAATTTTAAATAAACAACAAAAGCAGGTTTTCTGGGGAAT
ATTTGATATTTTCAGTATGGTGGTTTCCATCATTGTATCTTATATTTTATTTTATGGGCTGATTAATCCAGCACCTGTTG
ACTACATTATCTATACGAGTTTGACCTTCCTGTTCTATCAATTGATGATTGGTTTTTGGGGCTTGAACGCGAGTATTAGT
CGTTACAGCAAGATTACGGATTTCATGAAAATCTTTTTTGGTGCGACTGCCAGCAGTATCCTGTCATATAGTATCTGCTA
TGCCTTCTTGCCACTCTTCTCCATCCGTTTCATCATTCTCTTTATCTTGTTGAGTACCTTCTTGATTTTATTGCCACGGA
TTACTTGGCAGTTAATCTACTCCAGACGCAAAAAAGGTAGTGGTGATGGAGAACACCGTCGTACCTTCTTGATTGGTGCT
GGTGATGGTGGGGCTCTCTTTATGGATAGCTACCAACATCCAACTAGTGAATTGGAACTTGTTGGTATTTTGGATAAGGA
TGCTAAGAAAAAGGGTCAAAGACTTGGTGGTATCCCTGTTTTAGGCTCTTATGACAATCTGTCTGAATTAGCCAAACGCC
ATCAAATCGAGCGTGTCATCGTTGCGATTCCGTCGCTGGATCCGTTAGAATATGAGCGTATCTTGCAGATGTGTAATAAG
CTGGGTGTCAAATGTTACAAGATGCCTAAGGTTGAAACTGTTGTTCAGGGCCTTCACCAAGCAGGTACTGGCTTCCAAAA
AATTGATATTACGGACCTTTTGGGTCGTCAGGAAATCCGTCTTGACGAATCGCGTCTGGGTGCAGAACTGACAGGTAAGA
CCATCTTAGTCACAGGAGCTGGAGGTTCAATCGGTTCTGAAATCTGTCGTCAAGTTAGTCGCTTCAATCCTGAACGCATT
GTCTTGCTCGGTCATGGGGAAAACTCAATCTACCTTGTTTATCATGAATTAATTCGTGAGATCCAAGGGATTGATTATGT
ACCTGTGATTGCGGACATTCAAGACTATGATCGTTTGTTGCAAGTCTTTGAGCAGTACAAACCTGCTATTGTTTATCATG
CGGCAGCCCACAAGCATGTTCCTATGATGGAGCGCAATCCAAAAGAAGCCTTCAAAAACAATATCCGTGGAACTTACAAT
GTTGCTAAGGCTGTTGATGAAGCTAAAGTGTCTAAGATGGTTATGATTTCGACAGATAAGGCAGTTAATCCACCAAATGT
TATGGGAGCAACCAAGCGCGTGGCGGAGTTGATTGTCACTGGCTTTAACCAACGTAGCCAATCAACCTACTGTGCAGTTC
GTTTTGGGAATGTTCTTGGTAGCCGTGGTAGTGTCATTCCAGTCTTTGAACGTCAGATTGCTGAAGGTGGGCCTGTAACG
GTGACAGACTTCCGCATGACCCGTTACTTTATGACCATTCCAGAAGCTAGCCGTCTGGTTATCCATGCTGGTGCTTATGC
CAAAGATGGGGAAGTCTTTATCCTTGATATGGGCAAACCAGTCAAGATTTATGACTTGGCCAAGAAGATGGTGCTTCTAA
GTGGCCACACTGAAAGTGAAATTCCAATCGTTGAAGTTGGAATCCGCCCAGGTGAAAAACTCTACGAAGAACTCTTGGTA
TCAACCGAACTCGTTGACAATCAAGTTATGGATAAGATTTTCGTTGGTAAGGTTAATGTCATGCCTTTAGAATCCATCAA
TCAAAAGATTGGAGAGTTCCGCACTCTCAGTGGAGATGAATTGAAGCAAGCTATTATCGCCTTTGCTAATCAAACAACCC
ACATTGAATAA

Protein sequence :
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLTFLFYQLMIGFWGLNASIS
RYSKITDFMKIFFGATASSILSYSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
GDGGALFMDSYQHPTSELELVGILDKDAKKKGQRLGGIPVLGSYDNLSELAKRHQIERVIVAIPSLDPLEYERILQMCNK
LGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERI
VLLGHGENSIYLVYHELIREIQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYN
VAKAVDEAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVT
VTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLV
STELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cap1D AAA64643.1 type 1 capsule synthesis gene Virulence SCCcap1 Protein 2e-98 54
SSP0063 YP_300153.1 capsular polysaccharide biosynthesis protein Not tested SCC15305cap Protein 7e-100 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SP70585_0166 YP_002739477.1 CapD protein, required for the biosynthesis of type 1 capsular polysaccharide VFG1300 Protein 3e-95 51