Gene Information

Name : tkt1 (SP70585_1657)
Accession : YP_002740882.1
Strain : Streptococcus pneumoniae 70585
Genome accession: NC_012468
Putative virulence/resistance : Unknown
Product : transketolase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0021
EC number : 2.2.1.1
Position : 1528040 - 1530010 bp
Length : 1971 bp
Strand : -
Note : catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during expo

DNA sequence :
ATGTCACTACAATCAGTTAACGCCATTCGTTTTCTTGGCGTAGATGCTATTAACAAATCTAATTCTGGTCACCCGGGAAT
CGTCATGGGTGCTGCGCCAATGGCTTATAGCCTATTTACAAAGCACCTTAGAATTACACCTGAGCAGCCAAACTGGATTA
ACCGAGATCGCTTTATCTTGTCTGCGGGTCATGGATCAATGCTACTGTATGCTCTCTTGCATTTAACAGGGTATAACGAT
GTATCCATGGACGAGATTAAAAATTTCCGGCAATGGGGATCTAAGACACCTGGTCATCCTGAAGTGACGCATACGTCTGG
TGTGGATGCGACATCTGGTCCGCTTGGTCAGGGGATTTCTACTGCCGTTGGTTTCGCCCAAGCAGAGCGTTTTTTAGCTG
CTAAGTACAACAAAGATGGTTTTCCTATTTTTGACCATTATACTTATGTTATCGCTGGAGACGGTGACTTCATGGAAGGA
GTGTCTGCGGAGGCGGCTTCTTATGCAGGTCATCAAGCTTTAGATAAGCTTATCGTCCTCTACGACTCCAACGATATCTG
CTTGGATGGTGAGACCAAAGATACTTTCTCTGAAAATGTTCGCGCCCGTTACGATGCTTATGGTTGGCATACAGTTCTGG
TAGAAGATGGAACAGATTTAGCAGCAATTTCTACAGCAATTGAGACGGCCAAGTTTTCTGGTAAGCCGAGTTTGATTGAA
GTGAAAACGGTAATTGGTTACGGCTCACCCAATAAAAGTGGTACAAATGCTGTTCATGGTGCACCACTAGGAGCAGAAGA
AACAGGAGCAACTCGTAAGTTTTTGGGATGGGATTACGATCCATTTGAAGTACCAGAGGAAGTATATTCTGATTTCAAGA
CAAATGTAGCGGATCGTGGTCAGGAGGCATACGATGCTTGGGCTAGTTTGGTGTCTGATTACAAGGTTGCTTATCCCGAA
GTTGCTAGTGAGATTGACGCTATTGTAGCTGGAAAATCCCCTGTAACCATTACTGAAAAAGACTTCCCTGTCTATGAGAA
TGGCTTCTCTCAAGCAACTCGTAATTCGTCCCAAGATGCTATTAATACAGCAGCAGCAGTTTTACCAACCTTCTTAGGTG
GATCGGCAGACTTAGCTCACTCCAACATGACCTACATCAAGGCAGATGGCTTACAAGATAAATATAATCCATTAAACCGC
AATATTCAGTTTGGGGTACGTGAATTTGCCATGGGAACAATCCTCAATGGAATGGCTCTTCATGGTGGTTTACGAGTTTA
TGGCGGAACCTTCTTTGTTTTCTCTGACTACATCAAAGCTGCTATTCGGCTATCAGCCATTCAGGAGTTGCCTGTAACTT
ATGTCTTTACCCATGATTCAATTGCCGTTGGTGAAGATGGTCCAACTCATGAACCAGTTGAACATTTGGCAGGTTTACGC
TCAATGCCAAACTTGACTGTTATCCGTCCAGCGGATGCCCGTGAAACTCAAGCGGCTTGGCATCATGCCTTGACCAGTAC
CACCACTCCAACTGTCATTGTCTTAACCCGTCAAAACTTGGTAGTTGAAGAAGGGACAGACTTTGGTAAGGTCGCTAAAG
GAGCCTACGTCGTGTATGATACCCCGGGATTTGATACTATTATCATTGCTACAGGATCTGAGGTCAATCTAGCTATCAAA
GCTGCTAAGGAATTGGTTTTACAAGGTGGTAAAGTACGTGTGGTATCTATGCCCTCAACCGAACTATTTGATGCTCAAGA
TGCTACCTACAAGGAAGACATTTTACCATCTAAGACTCGTCGTCGTGTGGCCATTGAAATGGCAGCGACCCAAAGTTGGT
ACAAGTATGTTGGTTTGGATGGCGCGGTCATCGGTATTGACATCTTCGGTGCGTCTGCCCCAGCTCAGACTGTGATTGAT
AATTATGGATTTACGGTAGAGAATATCGTTGCTCAAGTTAAGTCCCTATAG

Protein sequence :
MSLQSVNAIRFLGVDAINKSNSGHPGIVMGAAPMAYSLFTKHLRITPEQPNWINRDRFILSAGHGSMLLYALLHLTGYND
VSMDEIKNFRQWGSKTPGHPEVTHTSGVDATSGPLGQGISTAVGFAQAERFLAAKYNKDGFPIFDHYTYVIAGDGDFMEG
VSAEAASYAGHQALDKLIVLYDSNDICLDGETKDTFSENVRARYDAYGWHTVLVEDGTDLAAISTAIETAKFSGKPSLIE
VKTVIGYGSPNKSGTNAVHGAPLGAEETGATRKFLGWDYDPFEVPEEVYSDFKTNVADRGQEAYDAWASLVSDYKVAYPE
VASEIDAIVAGKSPVTITEKDFPVYENGFSQATRNSSQDAINTAAAVLPTFLGGSADLAHSNMTYIKADGLQDKYNPLNR
NIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYIKAAIRLSAIQELPVTYVFTHDSIAVGEDGPTHEPVEHLAGLR
SMPNLTVIRPADARETQAAWHHALTSTTTPTVIVLTRQNLVVEEGTDFGKVAKGAYVVYDTPGFDTIIIATGSEVNLAIK
AAKELVLQGGKVRVVSMPSTELFDAQDATYKEDILPSKTRRRVAIEMAATQSWYKYVGLDGAVIGIDIFGASAPAQTVID
NYGFTVENIVAQVKSL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tktA AAO17218.1 TktA Not tested tcd island Protein 4e-146 49
APECO1_2641 YP_859417.1 transketolase Not tested Not named Protein 4e-141 48