Gene Information

Name : SPP_0162 (SPP_0162)
Accession : YP_002737394.1
Strain : Streptococcus pneumoniae P1031
Genome accession: NC_012467
Putative virulence/resistance : Virulence
Product : CapD protein, required for the biosynthesis of type 1 capsular polysaccharide
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1086
EC number : -
Position : 133309 - 135159 bp
Length : 1851 bp
Strand : +
Note : identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993

DNA sequence :
ATGAATAAAAAACTCACAGATTATGTGATTGATCTGGTGGAAATTTTAAATAAACAACAAAAGCAGGTTTTCTGGGGAAT
ATTTGATATTTTCAGTATGGTGGTTTCCATCATTGTATCTTATATTTTATTTTATGGGCTGATTAATCCAGCACCTGTTG
ACTACATTATCTATACGAGTTTGGCCTTCCTGTTCTATCAATTGATGGTTGATTTTTGGGGCTTGAGCGCGAGTATTAGT
CGTTACAGCAAGATTACGGATTTCATGAAAATCTTTTTTGGTGTGACTGCTAGCAGTGTCTTGTCATATAGTATCTGTTA
TGCCTTCTTGCCACTCTTCTCCATCCGTTTTATCATTCTCTTTATCTTGTTGAGTGCCTTCTTGATTTTATTGCCACGGA
TTACTTGGCAGTTAATCTACTCCAGACGCAAAAAAGGTAGTGGTGATGGAGAACACCGTCGGACCTTCTTGATTGGTGCC
GGTGATGGTGGGGCTCTCTTTATGGATAGTTACCAACATCCAACCAGTGAATTAGAACTGGTCGGTATTTTGGATAAGGA
TTCTAAGAAAAAGGGTCAAAAACTTGGTGGTATTCCTGTTTTGGGCTCTTATGACAATCTGCCTGAATTAGCCAAACGCC
ATCAAATCGAGCGTGTCATCGTTGCGATTCCGTCGCTGGATCCGTCAGAATATGAGCGTATCTTGCAGATGTGTAATAAG
CTGGGTGTCAAATGTTACAAGATGCCTAAGGTTGAAACTGTTGTTCAGGGCCTTCACCAAGCAGGTACTGGCTTCCAAAA
AATTGATATTACGGACCTTTTGGGTCGTCAGGAAATCCGTCTTGACGAATCGCGTCTGGGTGCAGAACTGACAGGTAAGA
CCATCTTAGTCACAGGAGCTGGAGGTTCAATCGGTTCTGAAATCTGTCGTCAAGTTAGTCGCTTCAATCCTGAACGCATT
GTCTTGCTCGGTCATGGGGAAAACTCAATCTACCTTGTTTATCATGAATTGATTCGTAAGTTCCAAGGGATTGATTATGT
ACCTGTGATTGCGGACATTCAAGACTATGATCGTTTGTTGCAAGTCTTTGAGCAGTACAAACCTGCTATTGTTTATCATG
CGGCAGCCCACAAGCATGTTCCTATGATGGAGCGCAATCCAAAAGAAGCCTTCAAAAACAATATCCGTGGAACTTACAAT
GTTGCTAGAGCCGTTGATGAAGCCAAGGTGCCTAAGATGGTTATGATTTCGACAGATAAGGCAGTCAATCCACCAAATGT
TATGGGAGCAACCAAGCGCGTGGCGGAGTTGATTGTCACTGGCTTTAACCAACGTAGCCAATCAACCTACTGTGCAGTTC
GTTTTGGGAATGTTCTTGGTAGCCGTGGTAGTGTCATTCCAGTCTTTGAACGTCAGATTGCTGAAGGTGGGCCTGTAACG
GTGACAGACTTCCGCATGACCCGTTACTTTATGACCATTCCAGAAGCTAGCCGTCTGGTTATCCATGCTGGTGCTTATGC
CAAAGATGGGGAAGTCTTTATCCTTGATATGGGCAAACCAGTCAAGATTTATGACTTGGCCAAGAAGATGGTGCTTCTAA
GTGGCCACACTGAAAGTGAAATTCCAATCGTTGAAGTTGGAATCCGCCCAGGTGAAAAACTCTACGAAGAACTCTTGGTA
TCAACCGAACTCGTTGATAATCAAGTTATGGATAAGATTTTCGTTGGTAAGGTTAATGTCATGCCTTTAGAATCCATCAA
TCAAAAGATTGGAGAGTTCCGCACTCTCAGTGGAGATGAGTTGAAGCAAGCTATTATCGCCTTTGCTAATCAAACAACCC
ACATTGAATAA

Protein sequence :
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMVDFWGLSASIS
RYSKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSAFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
GDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNK
LGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERI
VLLGHGENSIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYN
VARAVDEAKVPKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVT
VTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLV
STELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cap1D AAA64643.1 type 1 capsule synthesis gene Virulence SCCcap1 Protein 2e-100 55
SSP0063 YP_300153.1 capsular polysaccharide biosynthesis protein Not tested SCC15305cap Protein 3e-101 52

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPP_0162 YP_002737394.1 CapD protein, required for the biosynthesis of type 1 capsular polysaccharide VFG1300 Protein 1e-97 51