Gene Information

Name : SPP_1155 (SPP_1155)
Accession : YP_002738300.1
Strain : Streptococcus pneumoniae P1031
Genome accession: NC_012467
Putative virulence/resistance : Resistance
Product : tetracycline resistance protein TetM
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0480
EC number : -
Position : 1072571 - 1074490 bp
Length : 1920 bp
Strand : -
Note : identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM PF03764; match to protein family HMM TIGR00231

DNA sequence :
ATGAAAATTATTAATATTGGAGTTTTAGCTCATGTTGATGCGGGAAAAACTACCTTAACAGAAAGCTTATTATATAACAG
TGGAGCGATTACAGAATTAGGAAGCGTGGACAGAGGTACAACGAAAACGGATAATACGCTTTTAGAACGTCAGAGAGGAA
TTACAATTCAGACGGCGATAACCTCTTTTCAGTGGAAAAATACTAAGATAAACATCATAGACACGCCAGGACATATGGAT
TTTTTAGCAGAAGTATATCGTTCATTATCAGTATTAGATGGGGCAATTCTACTGATTTCTGCAAAAGATGGCGTACAAGC
ACAAACTCGTATATTGTTTCATGCACTTAGGAAAATAGGTATTCCCACAATCTTTTTTATCAATAAGATTGACCAAAATG
GAATTGATTTATCAACGGTTTATCAGGATATTAAAGAGAAACTTTCTGCGGAAATTGTAATCAAACAGAAGGTAGAACTG
CATCCTAATATGCGTGTAATGAACTTTACCGAATCTGAACAATGGGATATGGTAATAGAAGGAAATGATTACCTTTTGGA
GAAATATACGTCTGGGAAATTATTGGAAGCATTAGAACTCGAACAAGAGGAAAGCATAAGATTTCATAATTGTTCCCTGT
TCCCTGTTTATCACGGAAGTGCAAAAAACAATATAGGGATTGATAACCTTATAGAAGTGATTACGAATAAATTTTATTCA
TCAACACATCGAGGTCAGTCTGAACTTTGCGGAAAAGTTTTCAAAATTGAGTATTCGGAAAAAAGACAGCGTCTTGCATA
TATACGTCTTTATAGTGGCGTACTGCATTTGCGAGATTCGGTTAGAATATCGGAAAAGGAAAAAATAAAAATTACAGAAA
TGTATACTTCAATAAATGGTGAATTATGTAAAATCGATAAGGCTTATTCCGGGGAAATTGTTATTTTGCAGAATGAGTTT
TTGAAGTTAAATAGTGTTCTTGGAGATACAAAGCTATTGCCACAGAGAGAGAGAATTGAAAATCCCCTCCCTCTGCTGCA
AACGACTGTTGAACCGAGCAAACCTCAACAAAGGGAAATGTTACTTGATGCACTTTTAGAAATCTCCGACAGTGACCCGC
TTCTGCGATATTATGTGGATTCTGCGACACATGAAATCATACTTTCTTTCTTAGGGAAAGTACAAATGGAAGTGACTTGT
GCTCTGCTGCAAGAAAAGTATCATGTGGAGATAGAAATAAAAGAGCCTACAGTCATTTATATGGAAAGACCGTTAAAAAA
AGCAGAGTATACCATTCACATCGAAGTTCCACCGAATCCTTTCTGGGCTTCCATTGGTCTATCTGTAGCACCGCTTCCAT
TAGGGAGCGGAGTACAGTATGAGAGCTCGGTTTCTCTTGGATACTTAAATCAATCGTTTCAAAATGCAGTTATGGAGGGG
ATACGCTATGGCTGTGAACAAGGATTGTATGGTTGGAATGTGACGGACTGTAAAATCTGTTTTAAGTATGGCTTATACTA
TAGCCCTGTTAGTACCCCAGCAGATTTTCGGATGCTTGCTCCTATTGTATTGGAACAAGTCTTAAAAAAAGCTGGAACAG
AATTGTTAGAGCCATATCTTAGTTTTAAAATTTATGCGCCACAGGAATATCTTTCACGAGCATACAACGATGCTCCTAAA
TATTGTGCGAACATCGTAGACACTCAATTGAAAAATAATGAGGTCATTCTTAGTGGAGAAATCCCTGCTCGGTGTATTCA
AGAATATCGTAGTGATTTAACTTCCTTTACAAATGGACGTAGTGTTTGTTTAACAGAGTTAAAAGGGTACCATGTTACTA
CCGGTGAACCTGTTTGCCAGCCCCGTCGTCCAAATAGTCGGATAGATAAAGTACGATATATGTTCAATAAAATAACTTAG

Protein sequence :
MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDRGTTKTDNTLLERQRGITIQTAITSFQWKNTKINIIDTPGHMD
FLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKIGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVEL
HPNMRVMNFTESEQWDMVIEGNDYLLEKYTSGKLLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYS
STHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEF
LKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLGKVQMEVTC
ALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVAPLPLGSGVQYESSVSLGYLNQSFQNAVMEG
IRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPK
YCANIVDTQLKNNEVILSGEIPARCIQEYRSDLTSFTNGRSVCLTELKGYHVTTGEPVCQPRRPNSRIDKVRYMFNKIT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSU05_0922 YP_001198287.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 94
SSU98_0928 YP_001200485.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 94
tetO AFJ97266.1 truncated tetracycline resistant protein Not tested Not named Protein 2e-161 74
tet(W) YP_005160006.1 tetracycline resistance protein Not tested Not named Protein 0.0 69

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM X04388.gene.p01 Protein 0.0 99
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM M85225.gene.p01 Protein 0.0 95
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM NC_002758.1120355.p0 Protein 0.0 93
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM AM180355.1.gene636.p Protein 0.0 93
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM NC_009782.5559075.p0 Protein 0.0 93
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM L09756.gene.p01 Protein 0.0 79
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM AJ295238.gene.p01 Protein 0.0 72
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM AJ222769.gene.p01 Protein 0.0 69
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM AY485126.gene.p01 Protein 0.0 69
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM DQ294299.gene.p01 Protein 0.0 68
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM FN594949.1.gene24.p0 Protein 0.0 67
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM L42544.gene.p01 Protein 9e-130 45
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM AJ514254.gene.p01 Protein 7e-120 43
SPP_1155 YP_002738300.1 tetracycline resistance protein TetM Z21523.gene.p01 Protein 2e-106 41