Gene Information

Name : guaA (BMEA_B0360)
Accession : YP_002734166.1
Strain :
Genome accession: NC_012442
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 1.1.99.4
Position : 341161 - 342723 bp
Length : 1563 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGCACCACGGCATATCCTGACACAATCCTTATCATCGACTTTGGCAGCCAGGTCACGCAGCTTATTGCGCGGCGTGT
GCGCGAGGCCAATGTCTATTGCGAAATCGTTCCCTTCCAGTCTGCGGATGAGGCGTTCAAGCGGCTGCAGCCGAAGGGCG
TGATCCTTTCCGGCAGCCCGCATTCAACGACCGATATCGGTTCGCCGCGTGCGCCGCAGGCTATTTTTGATGCGGGTATT
CCGGTTCTCGGCATTTGTTATGGCGAGCAGACCATGTGCGCCCAGCTTGGCGGCAACGTGGAAAGCGGCCATGATCGCGA
GTTCGGCCGTGCTTTTCTCGATGTGCAGGAAGACAGTCCGCTCTTTGCCGGCATATGGGCCAAGGGCACCCGCCATCAGG
TCTGGATGAGCCATGGCGACCGTGTGACCTCGCTGCCGGATGGCTTCACCATCATCGGCACGTCGCCGAATGCGCCCTAC
GCGGTTATTGCGGATGAGAAGCGCAAATATTACGGCGTGCAGTTCCATCCGGAAGTTGTGCACACGCCGGACGGTGCAAA
GCTGTTGCAGAATTTCGTTCATCGCATTGTCGGGGTGAAGCCAGGCTGGACGATGGGGGCCTATCGCGAACAGGCTGTCG
AGGCGATCCGCAAACAGGTCGGCAGCGGCAAGGTTATCTGCGCGCTTTCAGGCGGCGTGGATTCTTCCGTGGCGGCACTT
CTGGCTCATGAAGCTGTCGGCGATCAACTGACATGCATTCTCGTTGATCACGGCCTGATGCGCAAAGACGAAGTGCAACA
GGTCGTGGAAATGTTCCGCGAGCATTACAATCTGCCGCTGATCCTGGTGGATGCTTCCGACCGCTTCATCGGCGCGCTTG
AGGGCGAAAGTGACCCGGAAAAGAAGCGCAAGACCATCGGTCGCCTGTTTATCGAAGTGTTCGAGGAAGAAGCAAGGAAA
CTTGGCGGCGCGGATTTCCTCGTGCAGGGTACGCTTTATCCTGACGTGATCGAAAGTGTTTCCTTTACCGGCGGTCCTTC
GGTCACGATCAAGTCGCACCATAATGTCGGCGGTTTGCCGGAGCGCATGAAGATGCAGCTTGTGGAGCCGCTGCGCGAGC
TTTTCAAGGATGAGGTTCGTCTGCTCGGCAAGGAACTCGGTCTGCCGGACAGCTTCATCGGGCGTCATCCGTTCCCCGGT
CCGGGTCTTGCGATCCGTTGTCCCGGCGGCGTCACGCGCGAGAAACTGGAAATCCTGCGCGAAGCGGACGCAATCTATCT
GGATGAAATCCGCAAGGCTGGCCTCTATGATGCGATCTGGCAGGCTTTCGCGGTTCTGCTTCCGGTGCAGACCGTGGGCG
TGATGGGGGATGGCCGCACTTACGAATTCGTTTGCGCCTTGCGCGCGGTGACTTCGGTGGACGGCATGACGGCGGATTTC
TACCACTACGACATGAATTTCCTCGGCAATGCGGCCACCCGCATCATCAACGAAGTCCGCGGCATCAACCGCGTTGTCTA
TGATGTGACCTCCAAGCCGCCCGGCACGATTGAGTGGGAATAA

Protein sequence :
MSTTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSPHSTTDIGSPRAPQAIFDAGI
PVLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSPLFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPY
AVIADEKRKYYGVQFHPEVVHTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAAL
LAHEAVGDQLTCILVDHGLMRKDEVQQVVEMFREHYNLPLILVDASDRFIGALEGESDPEKKRKTIGRLFIEVFEEEARK
LGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPG
PGLAIRCPGGVTREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-134 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-135 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-135 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-113 50