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Name : ureC (BMEA_A1405) Accession : YP_002733074.1 Strain : Genome accession: NC_012441 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.4.22.35 Position : 1338018 - 1339739 bp Length : 1722 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC DNA sequence : ATGACACAGATTTCCCGCCAGCAATACGCCGACCTTTATGGCCCGACAATTGGGGACAAGATAAGGCTTGGCGACTCCGA TCTTTACGTTGAAATCGAGAAGGATCTGCGCGCCACTTATGGCGACGAACTGCAATATGGTGGCGGAAAAACGCTGCGTG ACGGCATGGGGTCGGAAAATTTCCTTACCCAGGAAGCAGGCTGCCTCGATCTGGTCATTACCAATGTGACTGTCATCGAC GCCATACAGGGGGTTGTGAAGGCCGATGTCGGCATTCGCAACGGAAGGATCGTCGGCCTTGGAAAAGCAGGCAACCCTTC CACCATGGACGGTGTGACGCGCGGCCTTGTGACCGGCGCTTCAACCGACGCCATATCGGGCGAGCACCTTATCCTCACCG CGGGCGGCATGGATACCCATGTTCACTATATCGCGCCGCAGCAGGTGGAGGCCGCTCTCTCGAACGGCATCACCACGCTC TGGGGCGGCGGCATCGGGCCGGTTGACGGCACAAACGGCGTGACCACGACCAACGGGCCGTGGAATCTCGAAATGATGCT GCGCTCCATCGAGGGCCTGCCGATCAACTTTGGCATTCAGGGCAAGGGAAATTCCACCGGCATTGCACCTCTGATCGAGC AGCTGGAAGCAGGTGCCGCCGGTTTCAAGGTCCATGAAGACTATGGCGCCACGCCGGCTACAATTCGCGCCTGCCTTTCG GTTGCCGATGAATATGACGTGTCGGTGGCCGTCCATACGGATACGCTGAACGAATCCGGCTATGTCGAGGACACCATCGC AGCCTTCGACGGGCGCTCCGTCCACACCTATCACAGCGAAGGCGCAGGCGGCGGTCACGCGCCGGATCTGCTGAAAATGG TGGGCCAGAATAACATCCTGCCAAGCTCGACCAATCCGACATTGCCCTGCGGCAAGAACTCGGTCGCCGAACTCTTTGAT ATGATTATGGTATGCCATAATCTCAATCCGAGAATCCCTTCCGACGTCGCCTTTGCCGAAAGCCGTGTCCGCGCCGAAAC CATCGTCGCCGAAAGCGTGCTGCATGACATGGGTGCGATCTCGATGATCGGCTCGGATTCGCAGGCCATGGGCCGCATCG GCGAAACCTACCTTCGCGCCATACAAACTGCGGACGCCATGAAAAAGGCGCGCGGTCCGCTGCCGGAGGATGCGCCCGGA AACGACAATTTCCGCGTGCTGCGCTATATTGCGAAAGTGACCATCAATCCGGCGCTGACCGCCGGTGTCGGCGATGTAAT CGGCTCGATAGAGTCCGGCAAATTCGCAGATCTGGTGCTTTGGGAACCGGCCTTCTTCGGCGTCAAGCCGAAGCTCGTCC TCAAGGGCGGACTGGTGGCATGGGCCAATATGGGCGACCCGAACGCATCATTGCCGACCCCGCAGCCCATGTATTACCGC CCCATGTTCGCAGCCTATGGTTCTGCGCTCCAGAAGACCTCCATCACCTTCGTTTCGCGCGCGGCCTACGACAAGGGTGT CGCCGACCGCTTCGGCTTGCAGCGGCTGGTAATGCCCGTCTCCGGAACCCGCGTCATCGGCAAGGCCCACATGGTTCGCA ACAGCTATCTGCCGAATATCGAAGTCGATCCGCAGACTTTCGCGGTCAAGGTCGATGGCGTCCACGCAACGGTGAAGCCG CCACAGTCGATCTCGCTCAACCAGCTTTATTTCTTTAGCTGA Protein sequence : MTQISRQQYADLYGPTIGDKIRLGDSDLYVEIEKDLRATYGDELQYGGGKTLRDGMGSENFLTQEAGCLDLVITNVTVID AIQGVVKADVGIRNGRIVGLGKAGNPSTMDGVTRGLVTGASTDAISGEHLILTAGGMDTHVHYIAPQQVEAALSNGITTL WGGGIGPVDGTNGVTTTNGPWNLEMMLRSIEGLPINFGIQGKGNSTGIAPLIEQLEAGAAGFKVHEDYGATPATIRACLS VADEYDVSVAVHTDTLNESGYVEDTIAAFDGRSVHTYHSEGAGGGHAPDLLKMVGQNNILPSSTNPTLPCGKNSVAELFD MIMVCHNLNPRIPSDVAFAESRVRAETIVAESVLHDMGAISMIGSDSQAMGRIGETYLRAIQTADAMKKARGPLPEDAPG NDNFRVLRYIAKVTINPALTAGVGDVIGSIESGKFADLVLWEPAFFGVKPKLVLKGGLVAWANMGDPNASLPTPQPMYYR PMFAAYGSALQKTSITFVSRAAYDKGVADRFGLQRLVMPVSGTRVIGKAHMVRNSYLPNIEVDPQTFAVKVDGVHATVKP PQSISLNQLYFFS |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 3e-147 | 57 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 3e-147 | 57 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-130 | 53 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-130 | 53 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-130 | 53 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-130 | 53 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002733074.1 | urease subunit alpha | VFG0270 | Protein | 2e-141 | 56 |
