Gene Information

Name : guaA (SULAZ_1085)
Accession : YP_002729058.1
Strain : Sulfurihydrogenibium azorense Az-Fu1
Genome accession: NC_012438
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1006539 - 1008074 bp
Length : 1536 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCATCAAGGGATAGTTATTTTAGACTTTGGCTCGCAATACACACAACTTATAGCAAGAAGAATAAGAGAGCTTCACAT
TTACAGTGAAATACTTCCTTACAACACACCAGTTGAAGAAATACTAAAACACAACCCAAAAGGAATAATATTCTCTGGTG
GTCCTGCCTCTGTGTATGAAAAAGATGCACCAAAACCCGACGAAAGAGTTTACGACTTAGGACTACCTATACTTGGTATA
TGCTACGGACTACAACTTATAACTCATCACTTTGGCGGTGAAGTTGTAAAAGCAGACAAACACGAGTATGGAAGAGCCGA
AATTCAAGTTTTAAACCATGAAGATTTATTCTACGAAATTCCTGAGTTTACCCACGTTTGGATGAGCCATGCAGACAAAG
TTGTAAAACTACCACAAGGTTTTGAAGTCCTTGCAAGGTCTTTTAATGCACCTTATGCAGCTGTAAGGAATAAAGAAAAG
AAAATCTGGGGTGTTCAGTTTCATCCGGAAGTAAGTCATACCCTTTTAGGAAAAGAGATTCTTAAAAACTTTGCAGTTAG
AATATGTGGCTGTAAACAAGACTGGACTATGGGTAACTTCCTTATGGAAGAGATTGTAAAAATAAGACAGACTGTCGGTA
ATAAAAAAGCCATATGTGCACTATCTGGAGGAGTAGACTCATCAGTTGCAGCTGTTTTAGTTCATAACGCCATTGGAGAT
AACTTAACTTGTATATTTGTTGACAACGGATTACTTAGAAAAGGAGAGAGAGAACAAGTAGAAAAAACATTTAGAGATAA
CTTCCATATTCCTTTAATAGTAGTAGATGCAAGGGAAAGATTTTTAAATGCTTTAAAAGGTATAACTGACCCGGAGCAAA
AAAGAAAGATAATAGGAAACCTCTTTATAGAAGTATTTGAAGAAGAGGCCAAAAAGCTAAAAGATGTAGAGTTTTTAGTC
CAAGGGACCTTGTACCCTGATGTTATAGAGAGTGTGTCTGTGAAAGGACCTTCTGCCGTTATAAAAACTCACCACAATGT
AGGTGGTCTTCCAGAGAGAATGAACTTAAAACTAATTGAACCTTTAAGAGAACTTTTCAAAGATGAAGTGAGAGAGCTTG
GAAAAGAACTTGGTCTTCCTGATGAGATAATATACAGACAACCATTTCCGGGTCCGGGTCTTGCTATAAGAGTGATAGGA
GAAGTAACTCAAGAAAGTCTTGATATACTTAGAGAAGCCGATGCAATAGTTTTAGAAGAGATTAAAAAAGCCGGATTATA
CAAGGACCTATGGCAGTCATTTGCCGTTTTACTTCCAATCCATACAGTAGGAGTTATGGGAGATTATAGAACTTACGAGA
AAGTTATTGCAGTTAGAGCTGTAGAAAGTAGTGATGGTATGACAGCTGACTGGGCAAGACTTCCCTACGACCTGTTGGAT
ACAATTATGAGAAGGATAATAAACGAAGTAAAAGGTGTAAATAGGGTAGTGTACGATATATCTTCTAAACCACCTGCAAC
GATAGAGTGGGAATAA

Protein sequence :
MHQGIVILDFGSQYTQLIARRIRELHIYSEILPYNTPVEEILKHNPKGIIFSGGPASVYEKDAPKPDERVYDLGLPILGI
CYGLQLITHHFGGEVVKADKHEYGRAEIQVLNHEDLFYEIPEFTHVWMSHADKVVKLPQGFEVLARSFNAPYAAVRNKEK
KIWGVQFHPEVSHTLLGKEILKNFAVRICGCKQDWTMGNFLMEEIVKIRQTVGNKKAICALSGGVDSSVAAVLVHNAIGD
NLTCIFVDNGLLRKGEREQVEKTFRDNFHIPLIVVDARERFLNALKGITDPEQKRKIIGNLFIEVFEEEAKKLKDVEFLV
QGTLYPDVIESVSVKGPSAVIKTHHNVGGLPERMNLKLIEPLRELFKDEVRELGKELGLPDEIIYRQPFPGPGLAIRVIG
EVTQESLDILREADAIVLEEIKKAGLYKDLWQSFAVLLPIHTVGVMGDYRTYEKVIAVRAVESSDGMTADWARLPYDLLD
TIMRRIINEVKGVNRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-152 58
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-152 58
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-152 58
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-132 54