Gene Information

Name : invC (EpC_19920)
Accession : YP_002648998.1
Strain : Erwinia pyrifoliae Ep1/96
Genome accession: NC_012214
Putative virulence/resistance : Virulence
Product : ATP synthase SpaL
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 2245685 - 2246980 bp
Length : 1296 bp
Strand : -
Note : Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. catalytic subunit of a protein translocase

DNA sequence :
ATGTTTACACACATGTTGGTTCGTCTCGCTCATCCACTACGTATTCAAGGAAATGTGATAGAAGCATACCTTCCAGGAAC
GAAGATTGGAGAAATTTGTCAAATCCAGAAATCATTAGTTGAAAGTGAAGTTTTAGGACTCGCGCAAATAACCGGATTTA
ATAATGAACATACATTTTTAAGCCTCTTAACGGATAGTCAGGGTTTTTCACGAGAAAACGTATTGTTGCCAACGGGTAAG
CCTCTGCGCGTTGAGGTTCATGAGGGCATAAAAGGGGCCATCATTGATGCTACTGGAACGATCAAAGGGCATCTGGTTGA
TATGCCTGTTACTCCTTACACAAATGTAAAGAGTATTATGGCCTGCGGTTCGGCGCGTGATTTTAGCTTACGTAAACCAA
TAACAGAGCCATTGTTAACCGGAATTCGTGCCATTGATGGTTTGCTTACCTGTGGTCAGGGACAACGAATCGGAATTTTT
GCGACGGCTGGCTGTGGTAAAACATCGCTGATGAATATGCTAATCGAGCATTCAGAAGCGGATATCTATGTTATCGGCCT
GATAGGTGAACGAGGACGAGAAGTAACTGAATTCGTCGAATCAATGAAAAAGTCTTCAAGACGTTCAAGGATCGTAATAG
TTTATGCTACCTCGGACCGCTCTTCGGTGGAACGTAGTAATGCCGCACAAATTGCATCAAGTATTGCCGAGTATTTCAGT
GAGTTGGGCAACAATGTACTACTTTTTGTGGATTCGATCACCCGTTACGCCCGTGCGTTGCGTGACGTTGCACTGAGTAT
GGGGGAAATGCCCGTGCGTCGCGGCTATCCTGCATCAGTGTTTGAGGCGTTACCAAAGCTGCTCGAGCGGCCTGGTCGTT
TCCTCACCGGATCAATAACAGCATTTTATACTGTGCTAATTGAAAACGAAGAAGATCCAGATGTAATCGGTGATGAAGTG
CGCTCGATTTTGGATGGACATATCTACCTGAGCCGTAAACTCGCCGCTAAGGGGCATTATCCGGCCATTAATGTACTTAA
CAGTATTAGCAGAGTTTTTTCACAAGTAACAGAACGAAATCAGCAGCAAATGGCGAACTGCTTCCGTGATTTATTACAGC
GTCAACGTGATATGCAGCTATTTATTGATTTAGGCGAATATCACCGGGGTGAAAATGAGAATAATGATATTGCTTTTGAT
AAGAACGAACAAATGGAAGAATTTCTCAAACAAGATATGACAGAAAAAATGGAAATTTCGACCTGCATGGATATGTTATA
TGGATGCGTGGCATAA

Protein sequence :
MFTHMLVRLAHPLRIQGNVIEAYLPGTKIGEICQIQKSLVESEVLGLAQITGFNNEHTFLSLLTDSQGFSRENVLLPTGK
PLRVEVHEGIKGAIIDATGTIKGHLVDMPVTPYTNVKSIMACGSARDFSLRKPITEPLLTGIRAIDGLLTCGQGQRIGIF
ATAGCGKTSLMNMLIEHSEADIYVIGLIGERGREVTEFVESMKKSSRRSRIVIVYATSDRSSVERSNAAQIASSIAEYFS
ELGNNVLLFVDSITRYARALRDVALSMGEMPVRRGYPASVFEALPKLLERPGRFLTGSITAFYTVLIENEEDPDVIGDEV
RSILDGHIYLSRKLAAKGHYPAINVLNSISRVFSQVTERNQQQMANCFRDLLQRQRDMQLFIDLGEYHRGENENNDIAFD
KNEQMEEFLKQDMTEKMEISTCMDMLYGCVA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 8e-127 64
invC AAS66861.1 InvC Not tested SSR-2 Protein 1e-113 55
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-107 54
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-107 54
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 2e-107 54
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-107 54
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 4e-102 53
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 5e-70 45
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 5e-68 43
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 9e-75 43
lscN AAO18044.1 LscN Virulence TTSS locus Protein 5e-81 43
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 4e-73 43
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-73 43
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 6e-64 43
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-73 43
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-73 43
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-73 43
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 3e-68 43
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 5e-70 43
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 4e-70 43
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 2e-67 43
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 2e-67 43
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-74 43
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 6e-75 43
ECs4568 NP_312595.1 EscN Virulence LEE Protein 3e-67 42
escN AAC38383.1 EscN Virulence LEE Protein 2e-67 42
escN AAC31513.1 L0034 Virulence LEE Protein 2e-67 42
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 2e-67 42
escN NP_290268.1 hypothetical protein Virulence LEE Protein 3e-67 42
escN CAC81862.1 EscN protein Virulence LEE II Protein 6e-67 42
unnamed AAL06369.1 EscN Virulence LEE Protein 3e-65 42
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-66 42
escN AAK26715.1 EscN Virulence LEE Protein 8e-67 42
escN YP_003223475.1 translocator EscN Virulence LEE Protein 9e-67 42
escN AAL57542.1 EscN Virulence LEE Protein 8e-67 42
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 7e-67 42
escN CAI43874.1 EscN protein Virulence LEE Protein 7e-67 42
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 1e-68 42
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-75 42
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-75 42
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 9e-75 42
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 9e-75 42
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-74 42
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 4e-74 42
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-74 42
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 9e-68 41
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 5e-68 41
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 8e-71 41
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 1e-66 41
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 1e-66 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
invC YP_002648998.1 ATP synthase SpaL VFG1778 Protein 9e-109 57
invC YP_002648998.1 ATP synthase SpaL VFG2459 Protein 4e-117 55
invC YP_002648998.1 ATP synthase SpaL VFG1008 Protein 2e-105 54
invC YP_002648998.1 ATP synthase SpaL VFG0555 Protein 7e-108 54
invC YP_002648998.1 ATP synthase SpaL VFG0390 Protein 4e-79 44
invC YP_002648998.1 ATP synthase SpaL VFG2144 Protein 2e-72 44
invC YP_002648998.1 ATP synthase SpaL VFG0048 Protein 1e-78 44
invC YP_002648998.1 ATP synthase SpaL VFG0192 Protein 2e-82 43
invC YP_002648998.1 ATP synthase SpaL VFG0515 Protein 2e-73 43
invC YP_002648998.1 ATP synthase SpaL VFG0730 Protein 1e-67 42
invC YP_002648998.1 ATP synthase SpaL VFG0812 Protein 1e-67 42