Gene Information

Name : smpB (JTY_3120)
Accession : YP_002646166.1
Strain : Mycobacterium bovis Tokyo 172
Genome accession: NC_012207
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 3416437 - 3416919 bp
Length : 483 bp
Strand : -
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
GTGTCCAAGTCGTCGCGTGGCGGCCGGCAGATCGTTGCCAGCAATCGCAAAGCCCGGCACAACTATTCGATCATCGAGGT
GTTCGAGGCCGGGGTTGCGCTGCAAGGCACGGAGGTGAAGAGCCTGCGGGAAGGGCAGGCGTCGCTGGCCGATTCGTTCG
CCACCATCGACGACGGCGAAGTGTGGCTGCGCAACGCGCACATCCCGGAATACCGGCACGGCAGCTGGACCAACCACGAG
CCGCGACGCAACCGCAAACTGCTGTTGCATCGCCGCCAGATCGACACCTTGGTCGGCAAGATCCGCGAAGGCAACTTCGC
CCTGGTGCCGTTGTCGCTGTATTTCGCCGAAGGCAAGGTCAAGGTTGAGCTTGCGCTGGCCCGAGGCAAGCAAGCCCGCG
ACAAACGCCAGGACATGGCCCGTCGTGATGCCCAGCGTGAAGTGCTCCGCGAGTTGGGTCGGCGCGCTAAGGGCATGACC
TGA

Protein sequence :
MSKSSRGGRQIVASNRKARHNYSIIEVFEAGVALQGTEVKSLREGQASLADSFATIDDGEVWLRNAHIPEYRHGSWTNHE
PRRNRKLLLHRRQIDTLVGKIREGNFALVPLSLYFAEGKVKVELALARGKQARDKRQDMARRDAQREVLRELGRRAKGMT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 5e-49 67
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 4e-32 49
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 4e-23 43